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ATE187170T1 - 10-disacetoxytaxolderivate - Google Patents

10-disacetoxytaxolderivate

Info

Publication number
ATE187170T1
ATE187170T1 AT92920702T AT92920702T ATE187170T1 AT E187170 T1 ATE187170 T1 AT E187170T1 AT 92920702 T AT92920702 T AT 92920702T AT 92920702 T AT92920702 T AT 92920702T AT E187170 T1 ATE187170 T1 AT E187170T1
Authority
AT
Austria
Prior art keywords
disacetoxytaxol
derivatives
opt
aryl
protected
Prior art date
Application number
AT92920702T
Other languages
English (en)
Inventor
Robert A Holton
Shu-Hui Chen
Vittorio Farina
Original Assignee
Univ Florida State
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State, Bristol Myers Squibb Co filed Critical Univ Florida State
Application granted granted Critical
Publication of ATE187170T1 publication Critical patent/ATE187170T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT92920702T 1991-09-23 1992-09-22 10-disacetoxytaxolderivate ATE187170T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US90040892A 1992-06-18 1992-06-18

Publications (1)

Publication Number Publication Date
ATE187170T1 true ATE187170T1 (de) 1999-12-15

Family

ID=27117344

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92920702T ATE187170T1 (de) 1991-09-23 1992-09-22 10-disacetoxytaxolderivate

Country Status (15)

Country Link
EP (1) EP0642503B1 (de)
JP (1) JP3304088B2 (de)
KR (1) KR100239201B1 (de)
AT (1) ATE187170T1 (de)
AU (1) AU663732B2 (de)
CA (1) CA2119363C (de)
CZ (1) CZ287609B6 (de)
DE (1) DE69230379T2 (de)
DK (1) DK0642503T3 (de)
ES (1) ES2141727T3 (de)
FI (1) FI112479B (de)
HU (1) HU225474B1 (de)
NO (1) NO304740B1 (de)
UA (1) UA39860C2 (de)
WO (1) WO1993006093A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998656A (en) 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
EP0577082B1 (de) * 1992-07-01 1996-04-10 Bristol-Myers Squibb Company Fluor-Taxole mit Antitumor-Wirkung
US5681714A (en) * 1992-07-30 1997-10-28 Mount Sinai Hospital Corporation Nucleic acid encoding tek receptor tyrosine kinase
EP0582469A2 (de) * 1992-08-06 1994-02-09 Wisconsin Alumni Research Foundation Verfahren zur Herstellung von Taxol-Typ-Verbindungen vom Beta-Laktam-Vorläufer
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
CA2158862C (en) * 1993-03-22 2006-10-10 Robert A. Holton Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same
FR2711369B1 (fr) * 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
FR2721024B1 (fr) * 1994-06-09 1996-07-12 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5767296A (en) * 1994-06-09 1998-06-16 Daiichi Pharmaceutical Co., Ltd. Deacetoxytaxol derivatives
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
JP2001524067A (ja) * 1995-09-13 2001-11-27 フロリダ・ステイト・ユニバーシティ 放射線感作性タキサン類およびその医薬製剤
DE19621311A1 (de) 1996-05-28 1997-12-04 Bayer Ag Substituierte Phenyluracile
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
KR101096282B1 (ko) * 2009-04-24 2011-12-20 주식회사 삼양제넥스 탁산 유도체를 제조하는 방법
WO2014013903A1 (ja) 2012-07-19 2014-01-23 富士フイルム株式会社 タキサン系活性成分含有液体組成物、その製造方法及び液体製剤

Also Published As

Publication number Publication date
EP0642503A1 (de) 1995-03-15
WO1993006093A1 (en) 1993-04-01
HU225474B1 (en) 2006-12-28
AU2692692A (en) 1993-04-27
CZ66194A3 (en) 1995-07-12
ES2141727T3 (es) 2000-04-01
HU9400832D0 (en) 1994-06-28
JPH07502981A (ja) 1995-03-30
KR100239201B1 (ko) 2000-02-01
NO941021L (no) 1994-05-20
NO941021D0 (no) 1994-03-22
DK0642503T3 (da) 2000-05-22
DE69230379D1 (de) 2000-01-05
DE69230379T2 (de) 2000-05-25
JP3304088B2 (ja) 2002-07-22
HUT68422A (en) 1995-04-26
CA2119363C (en) 2001-07-17
CZ287609B6 (cs) 2001-01-17
AU663732B2 (en) 1995-10-19
FI941324L (fi) 1994-03-22
EP0642503A4 (de) 1994-07-07
FI941324A0 (fi) 1994-03-22
EP0642503B1 (de) 1999-12-01
UA39860C2 (uk) 2001-07-16
NO304740B1 (no) 1999-02-08
CA2119363A1 (en) 1993-04-01
FI112479B (fi) 2003-12-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee