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ATE171217T1 - Methoden zur synthese und reinigung von peptiden - Google Patents

Methoden zur synthese und reinigung von peptiden

Info

Publication number
ATE171217T1
ATE171217T1 AT95917774T AT95917774T ATE171217T1 AT E171217 T1 ATE171217 T1 AT E171217T1 AT 95917774 T AT95917774 T AT 95917774T AT 95917774 T AT95917774 T AT 95917774T AT E171217 T1 ATE171217 T1 AT E171217T1
Authority
AT
Austria
Prior art keywords
synthesis
purification
methods
peptides
peptide
Prior art date
Application number
AT95917774T
Other languages
English (en)
Inventor
Rony Tal
Hing C Wong
Clayton Casipit
Pierre-Andre Chavaillaz
Vaughan Wittman
Original Assignee
Sunol Molecular Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunol Molecular Corp filed Critical Sunol Molecular Corp
Application granted granted Critical
Publication of ATE171217T1 publication Critical patent/ATE171217T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C07K14/4706—Guanosine triphosphatase activating protein, GAP
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/72—Fusion polypeptide containing domain for protein-protein interaction containing SH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95917774T 1994-04-29 1995-05-01 Methoden zur synthese und reinigung von peptiden ATE171217T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/235,178 US5888775A (en) 1994-04-29 1994-04-29 Peptide synthesis and purification by fusion to penI protein or precipitation effective portion thereof

Publications (1)

Publication Number Publication Date
ATE171217T1 true ATE171217T1 (de) 1998-10-15

Family

ID=22884431

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95917774T ATE171217T1 (de) 1994-04-29 1995-05-01 Methoden zur synthese und reinigung von peptiden

Country Status (8)

Country Link
US (2) US5888775A (de)
EP (1) EP0706574B1 (de)
JP (1) JPH08512210A (de)
AT (1) ATE171217T1 (de)
AU (1) AU696349B2 (de)
CA (1) CA2165413A1 (de)
DE (1) DE69504795T2 (de)
WO (1) WO1995030016A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
US6962790B1 (en) 1998-09-23 2005-11-08 University Of Massachusetts Medical Center Predictive assay for immune response
DE29822972U1 (de) * 1998-12-28 1999-03-04 Sarnatech Paulmann & Crone GmbH, 58509 Lüdenscheid Vorrichtung zur Halterung von Getränkebehältern in Kraftfahrzeugen
DE19939578A1 (de) * 1999-08-20 2001-02-22 Biosyn Arzneimittel Gmbh Nukleinsäuremolekül, umfassend eine für ein Hämocyanin kodierende Nukleinsäuresequenz
WO2000055192A2 (de) * 1999-03-17 2000-09-21 Biosyn Arzneimittel Gmbh Hämocyanin und dafür kodierende nukleinsäuresequenz
US6358187B1 (en) 1999-05-19 2002-03-19 Carl M. Smith Apparatus for monitoring and displaying exertion data
FR2807064B1 (fr) * 2000-03-31 2004-07-23 Aventis Cropscience Sa Gene 763 de champignon phytopatogene et son utilisation pour l'identification de composes fongicides
JP2006503545A (ja) * 2002-02-14 2006-02-02 ラター， ウィリアム ジェイ． 処置される宿主における切断についてのキメラ分子
US20040101920A1 (en) * 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
US8293100B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952508A (en) * 1980-03-10 1990-08-28 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
EP0244147A3 (de) * 1986-04-28 1989-04-05 Merck & Co. Inc. Verfahren zur Reinigung hybrider Proteine
JPH0722509B2 (ja) * 1986-09-12 1995-03-15 味の素株式会社 温度感受性リプレツサ−とこれを利用した遺伝子の発現方法
US5215896A (en) * 1987-03-20 1993-06-01 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
JPH02100685A (ja) * 1988-10-05 1990-04-12 Res Dev Corp Of Japan ポリペプチド分泌発現ベクター，該ベクターで形質転換した微生物及び該微生物によるポリペプチドの製造
US5258502A (en) * 1989-01-30 1993-11-02 Massachusetts Institute Of Technology Immobilization and purification of fusion proteins using chitin-binding ability
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
DK0672141T3 (da) * 1992-10-23 2003-06-10 Immunex Corp Fremgangsmåder til fremstilling af opløselige, oligomere proteiner

Also Published As

Publication number Publication date
DE69504795D1 (de) 1998-10-22
WO1995030016A1 (en) 1995-11-09
EP0706574A1 (de) 1996-04-17
EP0706574B1 (de) 1998-09-16
CA2165413A1 (en) 1995-10-30
US5888775A (en) 1999-03-30
AU696349B2 (en) 1998-09-10
US5763284A (en) 1998-06-09
AU2371195A (en) 1995-11-29
JPH08512210A (ja) 1996-12-24
DE69504795T2 (de) 1999-05-12

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