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ATE163045T1 - Somatotropine des schweines mit modifikationen im bereich der alpha helix 1 und kombinationen mit anderen mutationen - Google Patents

Somatotropine des schweines mit modifikationen im bereich der alpha helix 1 und kombinationen mit anderen mutationen

Info

Publication number
ATE163045T1
ATE163045T1 AT91120396T AT91120396T ATE163045T1 AT E163045 T1 ATE163045 T1 AT E163045T1 AT 91120396 T AT91120396 T AT 91120396T AT 91120396 T AT91120396 T AT 91120396T AT E163045 T1 ATE163045 T1 AT E163045T1
Authority
AT
Austria
Prior art keywords
somatotropins
mutations
helix
alpha
combinations
Prior art date
Application number
AT91120396T
Other languages
English (en)
Inventor
Meir Fischer
Michael Richard Lebens
Deborah Tardy Chaleff
Original Assignee
Bio Technology General Corp
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp, American Cyanamid Co filed Critical Bio Technology General Corp
Application granted granted Critical
Publication of ATE163045T1 publication Critical patent/ATE163045T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mold Materials And Core Materials (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Secondary Cells (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91120396T 1990-11-30 1991-11-28 Somatotropine des schweines mit modifikationen im bereich der alpha helix 1 und kombinationen mit anderen mutationen ATE163045T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62165690A 1990-11-30 1990-11-30

Publications (1)

Publication Number Publication Date
ATE163045T1 true ATE163045T1 (de) 1998-02-15

Family

ID=24491070

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91120396T ATE163045T1 (de) 1990-11-30 1991-11-28 Somatotropine des schweines mit modifikationen im bereich der alpha helix 1 und kombinationen mit anderen mutationen

Country Status (20)

Country Link
US (1) US5548068A (de)
EP (1) EP0496973B1 (de)
JP (1) JPH05105634A (de)
KR (1) KR100193005B1 (de)
AT (1) ATE163045T1 (de)
CA (1) CA2056467C (de)
DE (1) DE69128877T2 (de)
DK (1) DK0496973T3 (de)
ES (1) ES2112847T3 (de)
FI (1) FI104489B (de)
GR (1) GR3026761T3 (de)
HU (1) HU215947B (de)
IE (1) IE914153A1 (de)
IL (1) IL100169A0 (de)
NO (1) NO301235B1 (de)
NZ (2) NZ240718A (de)
PT (1) PT99648B (de)
SG (1) SG49702A1 (de)
TW (1) TW198040B (de)
ZA (1) ZA919453B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6006079A (en) * 1997-06-13 1999-12-21 Motorola, Inc. Radio having a fast adapting direct conversion receiver
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
GB2384001B (en) * 2001-12-14 2004-02-04 Asterion Ltd Chimeric growth hormone-growth hormone receptor proteins
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
SG178002A1 (en) 2006-10-20 2012-02-28 Biogen Idec Inc Treatment of demyelinating disorders
BR112013020969A2 (pt) * 2011-02-23 2018-07-10 Massachusetts Inst Technology proteínas de membrana solúvel em água e métodos para a sua preparação e uso.
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2154627T3 (es) * 1988-08-24 2001-04-16 American Cyanamid Co Estabilizacion de somatotropinas mediante la modificacion de restos de cisteina utilizando mutagenesis de localizacion dirigida o derivatizacion quimica.
WO1990004788A1 (en) * 1988-10-28 1990-05-03 Genentech, Inc. Method for identifying active domains and amino acid residues in polypeptides and hormone variants

Also Published As

Publication number Publication date
ES2112847T3 (es) 1998-04-16
NO914724L (no) 1992-06-01
GR3026761T3 (en) 1998-07-31
DE69128877T2 (de) 1998-06-18
PT99648A (pt) 1992-10-30
NZ240718A (en) 1996-10-28
NO914724D0 (no) 1991-11-29
NO301235B1 (no) 1997-09-29
FI104489B (fi) 2000-02-15
AU8830091A (en) 1992-06-04
JPH05105634A (ja) 1993-04-27
AU662493B2 (en) 1995-09-07
EP0496973B1 (de) 1998-02-04
TW198040B (de) 1993-01-11
CA2056467A1 (en) 1992-05-31
SG49702A1 (en) 1998-06-15
PT99648B (pt) 1999-05-31
ZA919453B (en) 1992-08-26
FI915654A0 (fi) 1991-11-29
US5548068A (en) 1996-08-20
EP0496973A3 (en) 1993-02-24
CA2056467C (en) 1998-07-07
HU913723D0 (en) 1992-02-28
DE69128877D1 (de) 1998-03-12
FI915654L (fi) 1992-05-31
IL100169A0 (en) 1992-08-18
EP0496973A2 (de) 1992-08-05
IE914153A1 (en) 1992-06-03
NZ260103A (en) 1996-10-28
HUT62327A (en) 1993-04-28
DK0496973T3 (da) 1998-05-04
HU215947B (hu) 1999-03-29
KR920009413A (ko) 1992-06-25
KR100193005B1 (ko) 1999-06-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee