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ATE160589T1 - Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amid - Google Patents

Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amid

Info

Publication number
ATE160589T1
ATE160589T1 AT94924421T AT94924421T ATE160589T1 AT E160589 T1 ATE160589 T1 AT E160589T1 AT 94924421 T AT94924421 T AT 94924421T AT 94924421 T AT94924421 T AT 94924421T AT E160589 T1 ATE160589 T1 AT E160589T1
Authority
AT
Austria
Prior art keywords
beta
phenylglycine
phenylglycine amide
separation
enzymatic production
Prior art date
Application number
AT94924421T
Other languages
English (en)
Inventor
Wilhelmus Hubertus Jos Boesten
Harold Monro Moody
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of ATE160589T1 publication Critical patent/ATE160589T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94924421T 1993-07-19 1994-07-13 Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amid ATE160589T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE9300750A BE1007296A3 (nl) 1993-07-19 1993-07-19 Werkwijze voor de bereiding van een beta-lactamderivaat.

Publications (1)

Publication Number Publication Date
ATE160589T1 true ATE160589T1 (de) 1997-12-15

Family

ID=3887201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94924421T ATE160589T1 (de) 1993-07-19 1994-07-13 Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amid

Country Status (8)

Country Link
EP (1) EP0712443B1 (de)
KR (1) KR960704061A (de)
CN (1) CN1127531A (de)
AT (1) ATE160589T1 (de)
BE (1) BE1007296A3 (de)
DE (1) DE69407049T2 (de)
ES (1) ES2110255T3 (de)
WO (1) WO1995003420A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
BE1009264A3 (nl) * 1995-03-31 1997-01-07 Dsm Nv Werkwijze voor de winning van ampicilline.
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007076C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007077C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
KR100423442B1 (ko) * 1999-12-28 2004-03-19 주식회사 포스코 편류를 방지할 수 있는 연속주조용 슬라이딩 게이트장치
CN102851332A (zh) * 2012-09-07 2013-01-02 石药集团中诺药业（石家庄）有限公司 一种酶法氨苄西林母液中d（-）苯甘氨酸的回收方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187110C (nl) * 1976-11-10 1991-06-03 Stamicarbon Werkwijze voor het scheiden van een mengsel van een optisch aktief fenylglycine-amide en een optisch aktief fenylglycine.
NL9000386A (nl) * 1990-02-16 1991-09-16 Stamicarbon Werkwijze voor de bereiding van optisch aktief aminozuuramide.
NL9000387A (nl) * 1990-02-16 1991-09-16 Stamicarbon Werkwijze voor het racemiseren van een optisch aktief aminozuuramide.
ZA915142B (en) * 1990-07-04 1992-05-27 Novo Nordisk As Process for preparation of beta-lactams
WO1992012782A1 (en) * 1991-01-25 1992-08-06 Novo Nordisk A/S Process for separation of two solid components

Also Published As

Publication number Publication date
EP0712443B1 (de) 1997-11-26
EP0712443A1 (de) 1996-05-22
DE69407049D1 (de) 1998-01-08
BE1007296A3 (nl) 1995-05-09
CN1127531A (zh) 1996-07-24
DE69407049T2 (de) 1998-07-09
ES2110255T3 (es) 1998-02-01
KR960704061A (ko) 1996-08-31
WO1995003420A1 (en) 1995-02-02

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