ATE156125T1 - Substituierte alkylpiperidine und deren verwendung als inhibitoren der cholesterolsynthese - Google Patents
Substituierte alkylpiperidine und deren verwendung als inhibitoren der cholesterolsyntheseInfo
- Publication number
- ATE156125T1 ATE156125T1 AT90118331T AT90118331T ATE156125T1 AT E156125 T1 ATE156125 T1 AT E156125T1 AT 90118331 T AT90118331 T AT 90118331T AT 90118331 T AT90118331 T AT 90118331T AT E156125 T1 ATE156125 T1 AT E156125T1
- Authority
- AT
- Austria
- Prior art keywords
- alkylpiperidines
- inhibitors
- substituted
- cholesterol synthesis
- cholesterol
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- -1 substituted alkyl piperidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41203789A | 1989-09-22 | 1989-09-22 | |
| US55709190A | 1990-07-27 | 1990-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE156125T1 true ATE156125T1 (de) | 1997-08-15 |
Family
ID=27021609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90118331T ATE156125T1 (de) | 1989-09-22 | 1990-09-24 | Substituierte alkylpiperidine und deren verwendung als inhibitoren der cholesterolsynthese |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0420116B1 (de) |
| JP (1) | JP3053418B2 (de) |
| KR (1) | KR100191231B1 (de) |
| CN (1) | CN1050380A (de) |
| AT (1) | ATE156125T1 (de) |
| AU (1) | AU633973B2 (de) |
| CA (1) | CA2025490C (de) |
| DE (1) | DE69031154T2 (de) |
| ES (1) | ES2108004T3 (de) |
| FI (1) | FI904663A0 (de) |
| HU (1) | HUT55362A (de) |
| IE (1) | IE903423A1 (de) |
| IL (1) | IL95727A0 (de) |
| NO (1) | NO904135L (de) |
| NZ (1) | NZ235370A (de) |
| PT (1) | PT95390A (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5348964A (en) * | 1990-07-25 | 1994-09-20 | Merrell Dow Pharmaceuticals Inc. | Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis |
| US5350758A (en) * | 1992-07-08 | 1994-09-27 | Merrell Dow Pharmaceuticals Inc. | Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis |
| US5466687A (en) * | 1992-10-22 | 1995-11-14 | Dr. Karl Thomae Gmbh | Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation |
| DE4303840A1 (de) * | 1992-10-22 | 1994-08-11 | Thomae Gmbh Dr K | Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| FR2697250B1 (fr) * | 1992-10-28 | 1995-01-20 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanol et de 1,2,3,6-tétrahydro-beta,beta-diméthyl-4-pyridineéthanol, leur procédé de préparation et leur utilisation en thérapeutique. |
| FR2705343B1 (fr) * | 1993-05-17 | 1995-07-21 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
| DE19754795A1 (de) * | 1997-12-10 | 1999-06-17 | Boehringer Ingelheim Pharma | Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| CN102304031A (zh) * | 2011-05-13 | 2012-01-04 | 华东理工大学 | 苯甲醛衍生物及其在制备加兰他敏中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE866193C (de) * | 1937-06-02 | 1953-02-09 | Hydrierwerke A G Deutsche | Verfahren zur Herstellung von in der Amidgruppe substituierten Carbonsaeureamiden |
| US2580411A (en) * | 1948-10-23 | 1952-01-01 | Searle & Co | Dihexyl alanine dialkylamides |
| FR1261160A (fr) * | 1955-07-28 | 1961-05-19 | Procédé de préparation de n-t-alkyl-dialkylamino-amides | |
| NL109859C (de) * | 1957-09-27 | |||
| US3185678A (en) * | 1961-08-04 | 1965-05-25 | Colgate Palmolive Co | Polymethyleniminoalkylamides |
| DE1719388B2 (de) * | 1968-02-09 | 1976-04-29 | Bayer Ag, 5090 Leverkusen | Verfahren zum faerben von fasermaterialien aus polyacrylnitril oder acrylnitrilhaltigen mischpolymerisaten |
| GB1415682A (en) * | 1972-06-30 | 1975-11-26 | Wyeth John & Brother Ltd | Amides and thioamides |
| GB1420758A (en) * | 1972-07-12 | 1976-01-14 | Wyeth John & Brother Ltd | Anti-ulcer compositions |
| US3968211A (en) * | 1974-02-11 | 1976-07-06 | The Upjohn Company | Compositions and methods of use of amidines for anti-arrhythmic purposes |
| JPS55129255A (en) * | 1979-03-28 | 1980-10-06 | Kuraray Co Ltd | Farnesylacetamide compounds or their salts |
| DE2947649A1 (de) * | 1979-11-27 | 1981-08-06 | C.F. Spiess & Sohn GmbH & Co, 6719 Kleinkarlbach | Insektizide mittel |
| US4326067A (en) * | 1980-12-03 | 1982-04-20 | The Dow Chemical Company | Process for making N-(2-aminoethyl)amides |
| CS270556B2 (en) * | 1986-02-01 | 1990-07-12 | Nippon Chemiphar Co | Method of alkylendiamine derivative preparation |
-
1990
- 1990-09-17 CA CA002025490A patent/CA2025490C/en not_active Expired - Fee Related
- 1990-09-18 IL IL95727A patent/IL95727A0/xx unknown
- 1990-09-18 NZ NZ235370A patent/NZ235370A/en unknown
- 1990-09-19 JP JP2247636A patent/JP3053418B2/ja not_active Expired - Fee Related
- 1990-09-21 HU HU906010A patent/HUT55362A/hu unknown
- 1990-09-21 IE IE342390A patent/IE903423A1/en unknown
- 1990-09-21 PT PT95390A patent/PT95390A/pt not_active Application Discontinuation
- 1990-09-21 FI FI904663A patent/FI904663A0/fi not_active Application Discontinuation
- 1990-09-21 NO NO90904135A patent/NO904135L/no unknown
- 1990-09-21 AU AU63061/90A patent/AU633973B2/en not_active Ceased
- 1990-09-21 CN CN90107855A patent/CN1050380A/zh active Pending
- 1990-09-22 KR KR1019900015119A patent/KR100191231B1/ko not_active IP Right Cessation
- 1990-09-24 ES ES90118331T patent/ES2108004T3/es not_active Expired - Lifetime
- 1990-09-24 DE DE69031154T patent/DE69031154T2/de not_active Expired - Fee Related
- 1990-09-24 AT AT90118331T patent/ATE156125T1/de not_active IP Right Cessation
- 1990-09-24 EP EP90118331A patent/EP0420116B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUT55362A (en) | 1991-05-28 |
| AU6306190A (en) | 1991-01-31 |
| HU906010D0 (en) | 1991-03-28 |
| PT95390A (pt) | 1991-05-22 |
| IE903423A1 (en) | 1991-04-10 |
| KR910006231A (ko) | 1991-04-27 |
| AU633973B2 (en) | 1993-02-11 |
| CA2025490C (en) | 2003-09-16 |
| CN1050380A (zh) | 1991-04-03 |
| EP0420116A2 (de) | 1991-04-03 |
| FI904663A0 (fi) | 1990-09-21 |
| ES2108004T3 (es) | 1997-12-16 |
| DE69031154T2 (de) | 1998-01-02 |
| NO904135D0 (no) | 1990-09-21 |
| JPH03130262A (ja) | 1991-06-04 |
| IL95727A0 (en) | 1991-06-30 |
| CA2025490A1 (en) | 1991-03-23 |
| JP3053418B2 (ja) | 2000-06-19 |
| NO904135L (no) | 1991-03-25 |
| EP0420116B1 (de) | 1997-07-30 |
| DE69031154D1 (de) | 1997-09-04 |
| EP0420116A3 (en) | 1991-09-18 |
| NZ235370A (en) | 1994-03-25 |
| KR100191231B1 (ko) | 1999-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |