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ATE155143T1 - 2-SUBSTITUTED INDAN-2-MERCAPTOACETYLAMIDE COMPOUNDS WITH ENKEPHALINASE AND ACE INHIBITORY EFFECT - Google Patents

2-SUBSTITUTED INDAN-2-MERCAPTOACETYLAMIDE COMPOUNDS WITH ENKEPHALINASE AND ACE INHIBITORY EFFECT

Info

Publication number
ATE155143T1
ATE155143T1 AT92116180T AT92116180T ATE155143T1 AT E155143 T1 ATE155143 T1 AT E155143T1 AT 92116180 T AT92116180 T AT 92116180T AT 92116180 T AT92116180 T AT 92116180T AT E155143 T1 ATE155143 T1 AT E155143T1
Authority
AT
Austria
Prior art keywords
enkephalinase
mercaptoacetylamide
compounds
inhibitory effect
ace inhibitory
Prior art date
Application number
AT92116180T
Other languages
German (de)
Inventor
Alan M Warshawsky
Gary A Flynn
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE155143T1 publication Critical patent/ATE155143T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention relates to novel 2-substituted indane-2-mercaptoacetylaminde derivatives which are useful as inhibitors of enkephalinase and ACE.
AT92116180T 1991-09-27 1992-09-21 2-SUBSTITUTED INDAN-2-MERCAPTOACETYLAMIDE COMPOUNDS WITH ENKEPHALINASE AND ACE INHIBITORY EFFECT ATE155143T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76728691A 1991-09-27 1991-09-27
US92948192A 1992-08-20 1992-08-20

Publications (1)

Publication Number Publication Date
ATE155143T1 true ATE155143T1 (en) 1997-07-15

Family

ID=27117891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92116180T ATE155143T1 (en) 1991-09-27 1992-09-21 2-SUBSTITUTED INDAN-2-MERCAPTOACETYLAMIDE COMPOUNDS WITH ENKEPHALINASE AND ACE INHIBITORY EFFECT

Country Status (16)

Country Link
US (3) US5428158A (en)
EP (1) EP0534363B1 (en)
JP (1) JP3173675B2 (en)
KR (1) KR100271239B1 (en)
AT (1) ATE155143T1 (en)
AU (1) AU657166B2 (en)
CA (1) CA2078758C (en)
DE (1) DE69220744T2 (en)
DK (1) DK0534363T3 (en)
ES (1) ES2106112T3 (en)
FI (1) FI101303B (en)
GR (1) GR3024850T3 (en)
HU (1) HU214820B (en)
IL (1) IL103263A (en)
NO (1) NO300848B1 (en)
NZ (1) NZ244461A (en)

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Also Published As

Publication number Publication date
FI924311A (en) 1993-03-28
IL103263A0 (en) 1993-02-21
GR3024850T3 (en) 1998-01-30
FI101303B1 (en) 1998-05-29
JPH05294963A (en) 1993-11-09
KR100271239B1 (en) 2001-02-01
US5529996A (en) 1996-06-25
NO300848B1 (en) 1997-08-04
IL103263A (en) 1996-11-14
NO923744L (en) 1993-03-29
US5486513A (en) 1996-01-23
KR930006027A (en) 1993-04-20
EP0534363A2 (en) 1993-03-31
DE69220744D1 (en) 1997-08-14
NO923744D0 (en) 1992-09-25
HU9203074D0 (en) 1992-12-28
CA2078758A1 (en) 1993-03-28
CA2078758C (en) 2003-12-09
DE69220744T2 (en) 1997-11-13
NZ244461A (en) 1994-09-27
HU214820B (en) 1998-06-29
AU2524592A (en) 1993-04-01
DK0534363T3 (en) 1997-09-22
US5428158A (en) 1995-06-27
HUT65192A (en) 1994-05-02
ES2106112T3 (en) 1997-11-01
FI924311A0 (en) 1992-09-25
JP3173675B2 (en) 2001-06-04
EP0534363B1 (en) 1997-07-09
AU657166B2 (en) 1995-03-02
EP0534363A3 (en) 1993-06-09
FI101303B (en) 1998-05-29

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