ATE151813T1 - Stereospezifische trennung durch hydrolyse von 2- arylpropionsäureestern mit leberenzymen - Google Patents
Stereospezifische trennung durch hydrolyse von 2- arylpropionsäureestern mit leberenzymenInfo
- Publication number
- ATE151813T1 ATE151813T1 AT91905599T AT91905599T ATE151813T1 AT E151813 T1 ATE151813 T1 AT E151813T1 AT 91905599 T AT91905599 T AT 91905599T AT 91905599 T AT91905599 T AT 91905599T AT E151813 T1 ATE151813 T1 AT E151813T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrolysis
- acid esters
- liver enzymes
- arylpropionic acid
- stereospecific
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- 230000007062 hydrolysis Effects 0.000 title abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 241000283707 Capra Species 0.000 abstract 1
- 241000272201 Columbiformes Species 0.000 abstract 1
- 241000283073 Equus caballus Species 0.000 abstract 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 abstract 1
- 241000009328 Perro Species 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 abstract 1
- 229960000991 ketoprofen Drugs 0.000 abstract 1
- 229960002009 naproxen Drugs 0.000 abstract 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48436290A | 1990-02-26 | 1990-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE151813T1 true ATE151813T1 (de) | 1997-05-15 |
Family
ID=23923846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91905599T ATE151813T1 (de) | 1990-02-26 | 1991-02-25 | Stereospezifische trennung durch hydrolyse von 2- arylpropionsäureestern mit leberenzymen |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0517798B1 (de) |
| JP (1) | JPH05505936A (de) |
| AT (1) | ATE151813T1 (de) |
| CA (1) | CA2076972A1 (de) |
| DE (1) | DE69125708T2 (de) |
| WO (1) | WO1991013163A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9118149D0 (en) * | 1991-08-22 | 1991-10-09 | Enzymatix Ltd | Araylalkanoic acid resolution |
| GB9118150D0 (en) * | 1991-08-22 | 1991-10-09 | Enzymatix Ltd | Arylalkanoic acid resolution |
| ES2046950B1 (es) * | 1992-06-08 | 1994-10-01 | Menarini Lab | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
| US5457051A (en) * | 1993-03-09 | 1995-10-10 | Sepracor, Inc. | Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom |
| JP2002500881A (ja) * | 1998-01-26 | 2002-01-15 | フアーム−エコ・ラボラトリーズ・インコーポレーテツド | 鏡像異性体分離のための酵素活性化担体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4650755A (en) * | 1983-02-10 | 1987-03-17 | Purification Engineering, Inc. | Immobilizing microbial cells with polyfunctional aziridines |
| DE3345660A1 (de) * | 1983-12-16 | 1985-06-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur gewinnung von d(+)naproxen |
| GB8600245D0 (en) * | 1986-01-07 | 1986-02-12 | Shell Int Research | Preparation of 2-arylpropionic acids |
| US4800162A (en) * | 1987-04-01 | 1989-01-24 | Sepracor, Inc. | Method for resolution of steroisomers in multiphase and extractive membrane reactors |
| DE3919029A1 (de) * | 1989-06-10 | 1990-12-13 | Hoechst Ag | Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester |
-
1991
- 1991-02-25 AT AT91905599T patent/ATE151813T1/de not_active IP Right Cessation
- 1991-02-25 CA CA002076972A patent/CA2076972A1/en not_active Abandoned
- 1991-02-25 EP EP91905599A patent/EP0517798B1/de not_active Expired - Lifetime
- 1991-02-25 DE DE69125708T patent/DE69125708T2/de not_active Expired - Fee Related
- 1991-02-25 JP JP91505432A patent/JPH05505936A/ja active Pending
- 1991-02-25 WO PCT/US1991/001071 patent/WO1991013163A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991013163A1 (en) | 1991-09-05 |
| EP0517798A1 (de) | 1992-12-16 |
| EP0517798A4 (en) | 1993-06-30 |
| JPH05505936A (ja) | 1993-09-02 |
| DE69125708D1 (de) | 1997-05-22 |
| CA2076972A1 (en) | 1991-08-27 |
| EP0517798B1 (de) | 1997-04-16 |
| DE69125708T2 (de) | 1997-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |