[go: up one dir, main page]

ATE14585T1 - Beta-lactamase hemmende 2-beta-substituierte 2alpha-methyl-(5r)-penam-3-alpha-carbonsaeure-1,1 dioxide und zwischenprodukte. - Google Patents

Beta-lactamase hemmende 2-beta-substituierte 2alpha-methyl-(5r)-penam-3-alpha-carbonsaeure-1,1 dioxide und zwischenprodukte.

Info

Publication number
ATE14585T1
ATE14585T1 AT82304691T AT82304691T ATE14585T1 AT E14585 T1 ATE14585 T1 AT E14585T1 AT 82304691 T AT82304691 T AT 82304691T AT 82304691 T AT82304691 T AT 82304691T AT E14585 T1 ATE14585 T1 AT E14585T1
Authority
AT
Austria
Prior art keywords
beta
alpha
penam
dioxides
substituted
Prior art date
Application number
AT82304691T
Other languages
English (en)
Inventor
Wayne Ernest Barth
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE14585T1 publication Critical patent/ATE14585T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT82304691T 1981-09-14 1982-09-08 Beta-lactamase hemmende 2-beta-substituierte 2alpha-methyl-(5r)-penam-3-alpha-carbonsaeure-1,1 dioxide und zwischenprodukte. ATE14585T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/301,995 US4356174A (en) 1981-09-14 1981-09-14 Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
EP82304691A EP0074783B1 (de) 1981-09-14 1982-09-08 Beta-Lactamase hemmende 2-beta-substituierte 2-alpha-Methyl-(5R)-penam-3-alpha-carbonsäure-1,1-Dioxide und Zwischenprodukte

Publications (1)

Publication Number Publication Date
ATE14585T1 true ATE14585T1 (de) 1985-08-15

Family

ID=23165806

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82304691T ATE14585T1 (de) 1981-09-14 1982-09-08 Beta-lactamase hemmende 2-beta-substituierte 2alpha-methyl-(5r)-penam-3-alpha-carbonsaeure-1,1 dioxide und zwischenprodukte.

Country Status (25)

Country Link
US (1) US4356174A (de)
EP (1) EP0074783B1 (de)
JP (1) JPS5859990A (de)
KR (1) KR860001361B1 (de)
AT (1) ATE14585T1 (de)
AU (1) AU532401B2 (de)
CA (1) CA1212378A (de)
CS (1) CS236681B2 (de)
DE (1) DE3265082D1 (de)
DK (1) DK407882A (de)
ES (1) ES515649A0 (de)
FI (1) FI823165L (de)
GR (1) GR76726B (de)
HU (1) HU186575B (de)
IE (1) IE53819B1 (de)
IL (1) IL66776A (de)
IN (1) IN159366B (de)
NO (1) NO823093L (de)
NZ (1) NZ201895A (de)
PH (1) PH19442A (de)
PL (1) PL139272B1 (de)
PT (1) PT75548B (de)
SU (1) SU1272995A3 (de)
YU (1) YU205182A (de)
ZA (1) ZA826687B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760058A (en) * 1984-08-29 1988-07-26 Farmitalia Carlo Erba S.P.A. Penam derivatives
US4861768A (en) * 1986-02-27 1989-08-29 Taiho Pharmaceutical Company, Limited 2 β-substituted thiomethylpenicillin derivatives and their preparation and use
TW383308B (en) * 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
JP3866298B2 (ja) * 1997-12-29 2007-01-10 リサーチ コーポレイション テクノロジーズ，インコーポレイティド β−ラクタマーゼインヒビターとしての２β−置換化−６−アルキリデンペニシラン酸誘導体
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
EP1430060B1 (de) * 2001-07-24 2006-09-13 Southern Methodist University Foundation for Research 3-substituierte 7-alkylidene-3-cephem-4-carbonsäuren als beta-lactamase inhibitoren
AU2003224874A1 (en) * 2002-04-04 2003-10-27 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ss-LACTAMASES
KR100796131B1 (ko) * 2005-04-06 2008-01-21 후지쯔 가부시끼가이샤 휴대형 전자 기기
CN104650119B (zh) * 2015-02-10 2017-04-05 中国科学院长春应用化学研究所 一种β‑内酰胺化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1541832A (en) * 1976-02-11 1979-03-07 Beecham Group Ltd 2-substituted penam derivatives methods for their preparation and compisitions containing them
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
US4241050A (en) * 1978-09-01 1980-12-23 Pfizer Inc. Penam 1,1-dioxides as beta-lactamase inhibitors
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4256733A (en) * 1979-09-26 1981-03-17 Pfizer Inc. Acetoxymethyl penam compounds as β-lactamase inhibitors
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GR76726B (de) 1984-08-30
NO823093L (no) 1983-03-15
EP0074783B1 (de) 1985-07-31
ES8308566A1 (es) 1983-09-16
PL139272B1 (en) 1987-01-31
JPS6153354B2 (de) 1986-11-17
CA1212378A (en) 1986-10-07
ES515649A0 (es) 1983-09-16
PL238200A1 (en) 1985-02-13
CS236681B2 (en) 1985-05-15
HU186575B (en) 1985-08-28
ZA826687B (en) 1983-07-27
AU8833982A (en) 1983-03-24
IL66776A (en) 1985-07-31
KR860001361B1 (ko) 1986-09-16
YU205182A (en) 1985-03-20
DE3265082D1 (en) 1985-09-05
FI823165A0 (fi) 1982-09-13
IE53819B1 (en) 1989-03-01
PT75548B (en) 1985-12-09
US4356174A (en) 1982-10-26
PT75548A (en) 1982-10-01
FI823165L (fi) 1983-03-15
IE822232L (en) 1983-03-14
KR840001581A (ko) 1984-05-07
SU1272995A3 (ru) 1986-11-23
DK407882A (da) 1983-03-15
AU532401B2 (en) 1983-09-29
EP0074783A1 (de) 1983-03-23
NZ201895A (en) 1985-03-20
PH19442A (en) 1986-04-18
IN159366B (de) 1987-05-09
JPS5859990A (ja) 1983-04-09

Similar Documents

Publication Publication Date Title
ATE415394T1 (de) Zwischeprodukte zur herstellung von retroviralen protease-hemmern
DE69214397D1 (de) 2-Substituierte Indane-2-Carboxyalkyl-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
AU8581991A (en) Mercaptoacetylamide derivatives as inhibitors of enkephalinase and ACE, and processes for their production
IE801007L (en) Penicillins
MY123673A (en) Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors
GB2000138A (en) Therapeutic agents
DE69220744D1 (de) 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
ES2102367T3 (es) Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion.
DK0435321T3 (da) Nye A-nor-steroid-3-carboxylsyrederivater
IT8019276A0 (it) N-benzil-immidazoli come inibitori selettivi dell'enzima trombossano sintetasi, loro composizioni farmaceutiche e procedimento per la loro preparazione.
ATE14585T1 (de) Beta-lactamase hemmende 2-beta-substituierte 2alpha-methyl-(5r)-penam-3-alpha-carbonsaeure-1,1 dioxide und zwischenprodukte.
DE3853962D1 (de) Verfahren zur Kristallisation von Kalium-Clavulanat.
ATE29722T1 (de) Verfahren zur debrominierung von dibromopenicillansaeure und derivaten.
IE820342L (en) Penicillins
DE3261759D1 (en) Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
UA35554C2 (uk) Похідні хінолон- і нафтиридонкарбонової кислоти у вигляді суміші ізомерів або окремих ізомерів, фармацевтична композиція, що має антибактеріальну активність та проміжні сполуки
FR2341566A1 (fr) Produits de reaction d'amines, d'aldehydes et de dioxyde de soufre, utilisables comme inhibiteurs de corrosion
GB967542A (en) Penicillin derivatives

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee