ATE140924T1 - Neues verfahren zur 16-alpha methylierung von steroiden - Google Patents
Neues verfahren zur 16-alpha methylierung von steroidenInfo
- Publication number
- ATE140924T1 ATE140924T1 AT94400114T AT94400114T ATE140924T1 AT E140924 T1 ATE140924 T1 AT E140924T1 AT 94400114 T AT94400114 T AT 94400114T AT 94400114 T AT94400114 T AT 94400114T AT E140924 T1 ATE140924 T1 AT E140924T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- hydrogen
- beta
- optionally
- residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9300519A FR2700548B1 (fr) | 1993-01-20 | 1993-01-20 | Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE140924T1 true ATE140924T1 (de) | 1996-08-15 |
Family
ID=9443202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94400114T ATE140924T1 (de) | 1993-01-20 | 1994-01-19 | Neues verfahren zur 16-alpha methylierung von steroiden |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5508452A (de) |
| EP (1) | EP0608178B1 (de) |
| JP (1) | JP3535555B2 (de) |
| KR (1) | KR100284824B1 (de) |
| CN (1) | CN1040647C (de) |
| AT (1) | ATE140924T1 (de) |
| AU (1) | AU667147B2 (de) |
| CA (1) | CA2113776C (de) |
| DE (1) | DE69400340T2 (de) |
| DK (1) | DK0608178T3 (de) |
| ES (1) | ES2091095T3 (de) |
| FR (1) | FR2700548B1 (de) |
| GR (1) | GR3020751T3 (de) |
| HU (1) | HU221320B1 (de) |
| RU (1) | RU2127278C1 (de) |
| UA (1) | UA44887C2 (de) |
| ZA (1) | ZA94405B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040468A (en) * | 1996-10-25 | 2000-03-21 | Alcon Laboratories, Inc. | Method of preparing 16α, 17α-dialkylated steroids |
| US6841665B2 (en) | 2000-02-18 | 2005-01-11 | The University Of Hong Kong | Method for synthesizing 5β, 6β-epoxides of steroids by a highly β-selective epoxidation of ΔΔ5-unsaturated steroids catalyzed by ketones |
| CN103739647B (zh) | 2008-05-28 | 2017-06-09 | 雷沃根生物医药有限公司 | 用于治疗疾病的NF‑κB的非激素甾体调节剂 |
| WO2011127048A2 (en) | 2010-04-05 | 2011-10-13 | Validus Biopharma | NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE |
| WO2017004205A1 (en) | 2015-06-29 | 2017-01-05 | Reveragen Biopharma, Inc. | NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
| CN115322242B (zh) * | 2022-09-14 | 2023-09-12 | 山东赛托生物科技股份有限公司 | 一种高品质甾体药物中间体的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE28369E (en) * | 1957-02-27 | 1975-03-18 | Atcc-zxs | |
| US3080393A (en) * | 1960-02-04 | 1963-03-05 | Syntex Corp | Process for preparing 16alpha-methyl-17alpha-hydroxy-20-keto-pregnanes from the corresponding 16-dehydro-20-keto pregnanes |
| JPS504657B1 (de) * | 1968-07-30 | 1975-02-22 | ||
| US4022769A (en) * | 1974-05-13 | 1977-05-10 | Richardson-Merrell Inc. | Androst-4-en-19-ones |
| NL7607283A (nl) * | 1975-07-23 | 1977-01-25 | Merck & Co Inc | Werkwijze voor het bereiden van nieuwe pregnaansteroiden. |
| US4990612A (en) * | 1984-06-11 | 1991-02-05 | The Upjohn Company | 16α-methylation process |
| JPS611699A (ja) * | 1984-06-11 | 1986-01-07 | ジ アツプジヨン カンパニー | １６α‐メチル化法 |
| US4704455A (en) * | 1984-06-11 | 1987-11-03 | The Upjohn Company | 16α-methylatedΔ17(20)-corticoids |
| EP0308412B1 (de) * | 1986-06-04 | 1992-03-18 | The Upjohn Company | Verfahren zur 16-alpha methylierung |
| US4772755A (en) * | 1987-03-19 | 1988-09-20 | Mcneilab, Inc. | 1,2-1,4 addition reaction sequence leading to disubstituted acelylenes |
| FR2643638B1 (fr) * | 1989-02-24 | 1991-06-14 | Roussel Uclaf | Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| FR2692266B1 (fr) * | 1992-06-11 | 1994-08-05 | Roussel Uclaf | Nouveau procede de preparation de sterouides 16 alpha-methyles. |
-
1993
- 1993-01-20 FR FR9300519A patent/FR2700548B1/fr not_active Expired - Fee Related
-
1994
- 1994-01-12 US US08/180,454 patent/US5508452A/en not_active Expired - Lifetime
- 1994-01-19 HU HU9400156A patent/HU221320B1/hu unknown
- 1994-01-19 AU AU53847/94A patent/AU667147B2/en not_active Expired
- 1994-01-19 UA UA94005065A patent/UA44887C2/uk unknown
- 1994-01-19 CA CA002113776A patent/CA2113776C/fr not_active Expired - Lifetime
- 1994-01-19 KR KR1019940000937A patent/KR100284824B1/ko not_active IP Right Cessation
- 1994-01-19 ES ES94400114T patent/ES2091095T3/es not_active Expired - Lifetime
- 1994-01-19 RU RU94001576A patent/RU2127278C1/ru active
- 1994-01-19 DE DE69400340T patent/DE69400340T2/de not_active Expired - Lifetime
- 1994-01-19 CN CN94101077A patent/CN1040647C/zh not_active Expired - Lifetime
- 1994-01-19 DK DK94400114.8T patent/DK0608178T3/da active
- 1994-01-19 AT AT94400114T patent/ATE140924T1/de active
- 1994-01-19 JP JP01776294A patent/JP3535555B2/ja not_active Expired - Lifetime
- 1994-01-19 EP EP94400114A patent/EP0608178B1/de not_active Expired - Lifetime
- 1994-01-20 ZA ZA94405A patent/ZA94405B/xx unknown
-
1996
- 1996-08-08 GR GR960400219T patent/GR3020751T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2113776A1 (fr) | 1994-07-21 |
| KR100284824B1 (ko) | 2001-03-15 |
| HUT66233A (en) | 1994-10-28 |
| HU221320B1 (en) | 2002-09-28 |
| HU9400156D0 (en) | 1994-05-30 |
| DE69400340T2 (de) | 1997-01-23 |
| UA44887C2 (uk) | 2002-03-15 |
| GR3020751T3 (en) | 1996-11-30 |
| FR2700548A1 (fr) | 1994-07-22 |
| EP0608178B1 (de) | 1996-07-31 |
| AU5384794A (en) | 1994-07-28 |
| US5508452A (en) | 1996-04-16 |
| RU2127278C1 (ru) | 1999-03-10 |
| DE69400340D1 (de) | 1996-09-05 |
| KR940018396A (ko) | 1994-08-16 |
| JPH06293791A (ja) | 1994-10-21 |
| CN1103643A (zh) | 1995-06-14 |
| DK0608178T3 (da) | 1996-10-07 |
| FR2700548B1 (fr) | 1995-03-03 |
| EP0608178A1 (de) | 1994-07-27 |
| CN1040647C (zh) | 1998-11-11 |
| ES2091095T3 (es) | 1996-10-16 |
| AU667147B2 (en) | 1996-03-07 |
| JP3535555B2 (ja) | 2004-06-07 |
| ZA94405B (en) | 1995-01-20 |
| CA2113776C (fr) | 2004-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner |