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ATE138687T1 - Chimeres fibroblasten-wachstumsfaktor - Google Patents

Chimeres fibroblasten-wachstumsfaktor

Info

Publication number
ATE138687T1
ATE138687T1 AT91118725T AT91118725T ATE138687T1 AT E138687 T1 ATE138687 T1 AT E138687T1 AT 91118725 T AT91118725 T AT 91118725T AT 91118725 T AT91118725 T AT 91118725T AT E138687 T1 ATE138687 T1 AT E138687T1
Authority
AT
Austria
Prior art keywords
fibroblast growth
growth factor
chimeric
fgf
fgfs
Prior art date
Application number
AT91118725T
Other languages
English (en)
Inventor
Andrew P Seddon
Peter Bohlen
Yakov Gluzman
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE138687T1 publication Critical patent/ATE138687T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT91118725T 1990-11-23 1991-11-04 Chimeres fibroblasten-wachstumsfaktor ATE138687T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61520290A 1990-11-23 1990-11-23

Publications (1)

Publication Number Publication Date
ATE138687T1 true ATE138687T1 (de) 1996-06-15

Family

ID=24464425

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91118725T ATE138687T1 (de) 1990-11-23 1991-11-04 Chimeres fibroblasten-wachstumsfaktor

Country Status (16)

Country Link
US (3) US5310883A (de)
EP (1) EP0486862B1 (de)
JP (1) JP3205578B2 (de)
KR (1) KR100205078B1 (de)
AT (1) ATE138687T1 (de)
AU (1) AU646514B2 (de)
CA (1) CA2055963C (de)
DE (1) DE69119869T2 (de)
DK (1) DK0486862T3 (de)
ES (1) ES2087207T3 (de)
GR (1) GR3020237T3 (de)
IE (1) IE74956B1 (de)
IL (1) IL99984A (de)
NZ (1) NZ240622A (de)
PT (1) PT99565B (de)
ZA (1) ZA919260B (de)

Families Citing this family (42)

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US7252929B2 (en) 1989-02-09 2007-08-07 United States Of America, As Represented By The Secretary, Dept Of Health & Human Services Methods for identifying alpha PDGFR agonists and antagonists
US5951972A (en) * 1990-05-04 1999-09-14 American Cyanamid Company Stabilization of somatotropins and other proteins by modification of cysteine residues
US5206354A (en) * 1990-11-23 1993-04-27 American Cyanamid Company Dna sequence encoding active fragment of fibroblast growth factor, hbf-2
EP0486862B1 (de) * 1990-11-23 1996-05-29 American Cyanamid Company Chimeres Fibroblasten-Wachstumsfaktor
KR100374310B1 (ko) * 1995-02-14 2003-05-22 주식회사 엘지생명과학 변형된인간염기성섬유아세포성장인자및이의생산방법
EP0880598A4 (de) * 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
WO1997029701A1 (en) 1996-02-15 1997-08-21 Biosense Inc. Catheter based surgery
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US6927287B1 (en) * 1996-06-03 2005-08-09 United States Surgical Corporation Nucleic acid encoding extracellular matrix protein or fragment thereof
US6443974B1 (en) 1996-07-28 2002-09-03 Biosense, Inc. Electromagnetic cardiac biostimulation
US20030144202A1 (en) * 1996-10-15 2003-07-31 Amgen Inc. Uses of keratinocyte growth factor-2
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
ES2255155T3 (es) 1998-02-05 2006-06-16 Biosense Webster, Inc. Dispositivo para la administracion intracardiaca de farmacos.
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
US20030129750A1 (en) * 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
EP1071445A2 (de) * 1998-04-17 2001-01-31 Angiogenix, Incorporated Therapeutische angiogene faktoren und methoden zu deren verwendung
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins
US7022683B1 (en) * 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6313103B1 (en) 1998-05-13 2001-11-06 Carrington Laboratories, Inc. Pectic substance as a growth factor stabilizer
US6451303B1 (en) * 1998-10-13 2002-09-17 Chiron Corporation Method of treating coronary artery disease by administering a recombinant FGF
US20030166550A1 (en) * 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US8618052B2 (en) 1998-10-13 2013-12-31 Novartis Vaccines And Diagnostics, Inc. Method of treating coronary artery disease by administering FGF-5
US6440934B1 (en) 1998-10-13 2002-08-27 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US20020072489A1 (en) * 1998-10-13 2002-06-13 Whitehouse Martha J. Angiogenically effective unit dose of FGF-2 and method of use
CA2381780C (en) * 1999-08-13 2015-03-10 Chiron Corporation Dose of an angiogenic factor and method of administering to improve myocardial blood flow
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
IL149562A0 (en) 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
EP1926459B1 (de) 2005-09-19 2015-01-07 Histogenics Corporation Zellunterstützende matrix mit eng definierter, gleichmässig senkrecht und nicht zufällig organisierter porosität und porendichte und verfahren zur herstellung davon
USD566506S1 (en) * 2006-07-20 2008-04-15 Robert Bosch Gmbh Power operated screwdriver
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
EP2265220A1 (de) 2008-03-05 2010-12-29 Musculoskeletal Transplant Foundation Spongiosa-konstrukte, knorpelteilchen und kombinationen von spongiosa-konstrukten und knorpelteilchen
CN102076352B (zh) * 2008-05-02 2016-06-15 西安大略大学 与血管有关的fgf-9和它的用途
US9169309B2 (en) * 2011-03-01 2015-10-27 Humanzyme Inc. Thermostable variants of fibroblast growth factors
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN105859892A (zh) * 2016-06-08 2016-08-17 浙江大学 一种类胶原蛋白-人碱性成纤维细胞生长因子融合蛋白及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4378347A (en) * 1980-06-30 1983-03-29 Franco Wayne P Composition for treating the heart for myocardial infarction
US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US4902782A (en) * 1986-12-10 1990-02-20 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
EP0298723A1 (de) * 1987-07-07 1989-01-11 California Biotechnology, Inc. Rekombinante Fibroblasten-Wachstumsfaktoren
JPH02504468A (ja) * 1987-11-24 1990-12-20 アムジエン・インコーポレーテツド 繊維芽細胞成長因子のアナログ
US5130418A (en) * 1989-05-02 1992-07-14 California Biotechnology Inc. Method to stabilize basic fibroblast growth factor
EP0486862B1 (de) * 1990-11-23 1996-05-29 American Cyanamid Company Chimeres Fibroblasten-Wachstumsfaktor
CA2259333A1 (en) * 1996-06-29 1998-01-08 Dieter Muller Pharmaceutical administration form

Also Published As

Publication number Publication date
ES2087207T3 (es) 1996-07-16
KR920009848A (ko) 1992-06-25
US5310883A (en) 1994-05-10
AU8806291A (en) 1992-05-28
CA2055963A1 (en) 1992-05-24
DE69119869T2 (de) 1996-12-12
IE914068A1 (en) 1992-06-03
NZ240622A (en) 1994-08-26
US5371206A (en) 1994-12-06
CA2055963C (en) 2002-11-12
IL99984A0 (en) 1992-08-18
IE74956B1 (en) 1997-08-13
GR3020237T3 (en) 1996-09-30
IL99984A (en) 1998-12-06
KR100205078B1 (ko) 1999-06-15
US5302702A (en) 1994-04-12
ZA919260B (en) 1992-08-26
DK0486862T3 (da) 1996-06-24
EP0486862A1 (de) 1992-05-27
EP0486862B1 (de) 1996-05-29
DE69119869D1 (de) 1996-07-04
PT99565B (pt) 1999-04-30
JP3205578B2 (ja) 2001-09-04
JPH04330097A (ja) 1992-11-18
AU646514B2 (en) 1994-02-24
PT99565A (pt) 1992-10-30

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee