ATE12255T1 - Verfahren zur herstellung von selbstreproduzierenden pankreatischen inseln aehnlichen strukturen von saeugetieren. - Google Patents

Verfahren zur herstellung von selbstreproduzierenden pankreatischen inseln aehnlichen strukturen von saeugetieren.

Info

Publication number: ATE12255T1
Authority: AT; Austria
Prior art keywords: structures; ils; reproducing; self; procedure
Prior art date: 1981-10-21

Application number

AT82305595T

Other languages

English (en)

Inventor

Michael C Archer

Jain Kanti

Original Assignee

Ontario Cancer Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-10-21

Filing date

1982-10-21

Publication date

1985-04-15

1982-10-21 Application filed by Ontario Cancer Inst filed Critical Ontario Cancer Inst

1985-04-15 Application granted granted Critical

1985-04-15 Publication of ATE12255T1 publication Critical patent/ATE12255T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000012258 culturing Methods 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
210000004153 islets of langerhan Anatomy 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
230000001605 fetal effect Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
210000000496 pancreas Anatomy 0.000 abstract 1
210000000277 pancreatic duct Anatomy 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Cell Biology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Diabetes (AREA)
General Engineering & Computer Science (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Prostheses (AREA)

AT82305595T 1981-10-21 1982-10-21 Verfahren zur herstellung von selbstreproduzierenden pankreatischen inseln aehnlichen strukturen von saeugetieren. ATE12255T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/313,494 US4439521A (en)	1981-10-21	1981-10-21	Method for producing self-reproducing mammalian pancreatic islet-like structures
EP82305595A EP0078153B1 (de)	1981-10-21	1982-10-21	Verfahren zur Herstellung von selbstreproduzierenden pankreatischen Inseln ähnlichen Strukturen von Säugetieren

Publications (1)

Publication Number	Publication Date
ATE12255T1 true ATE12255T1 (de)	1985-04-15

Family

ID=23215924

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT82305595T ATE12255T1 (de)	1981-10-21	1982-10-21	Verfahren zur herstellung von selbstreproduzierenden pankreatischen inseln aehnlichen strukturen von saeugetieren.

Country Status (6)

Country	Link
US (1)	US4439521A (de)
EP (1)	EP0078153B1 (de)
JP (1)	JPS58135815A (de)
AT (1)	ATE12255T1 (de)
CA (1)	CA1179956A (de)
DE (1)	DE3262697D1 (de)

Families Citing this family (44)

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US4604346A (en) *	1984-10-09	1986-08-05	Massachusetts Institute Of Technology	Skin-equivalent prepared by the use of punch biopsy
NO166836C (no) *	1985-03-14	1991-09-11	Univ California	Fremgangsmaate for behandling av et organtransplantat.
US4935000A (en) *	1986-04-03	1990-06-19	East Carolina University	Extracellular matrix induction method to produce pancreatic islet tissue
US5079160A (en) *	1987-06-08	1992-01-07	Lacy Paul E	Method to isolate clusters of cell subtypes from organs
US5175004A (en) *	1988-12-27	1992-12-29	Matsumura Kenneth N	Propagatable, new combinant cells for cellular replacement therapy
JPH0493548U (de) *	1990-12-28	1992-08-13
US5821121A (en) *	1991-06-24	1998-10-13	Pacific Biomedical Research, Inc.	Hormone-secreting cells maintained in long-term culture
DE69232535D1 (de) *	1991-06-24	2002-05-08	Pacific Biomedical Res Inc	In langzeitkultur gehaltene hormon-absondernde pankreatische zellen
US5747341A (en) *	1991-06-24	1998-05-05	Pacific Biomedical Research, Inc.	Culture media having low osmolarity for establishing and maintaining hormone-secreting cells in long-term culture
AU687386B2 (en) *	1993-04-08	1998-02-26	Human Cell Cultures, Inc.	Cell culturing method and medium
US6008047A (en) *	1993-04-08	1999-12-28	Livercell L.L.C.	Cell culturing method and medium
US6001647A (en) *	1994-04-28	1999-12-14	Ixion Biotechnology, Inc.	In vitro growth of functional islets of Langerhans and in vivo uses thereof
US6703017B1 (en)	1994-04-28	2004-03-09	Ixion Biotechnology, Inc.	Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US6485723B1 (en) *	1995-02-10	2002-11-26	Purdue Research Foundation	Enhanced submucosal tissue graft constructs
US5695998A (en) *	1995-02-10	1997-12-09	Purdue Research Foundation	Submucosa as a growth substrate for islet cells
US5670358A (en) *	1995-10-19	1997-09-23	Baxter International Inc.	Method for inhibiting chymopapain and papain enzyme activity with polysaccharides of animal origin
AU7443996A (en) *	1995-10-30	1997-05-22	Vivorx, Inc.	Method for ex vivo proliferation and differentiation of adult pancreatic islet cells, media useful therefor and uses thereof
US6043092A (en) *	1996-03-18	2000-03-28	University Of Pittsburgh	Cell culture media for mammalian cells
US5804421A (en) *	1996-10-30	1998-09-08	Eastern Virginia Medical School Of The Medical College Fo Hampton Roads	High level of expression of ingap in bacterial and euraryotic cells
US6365385B1 (en)	1999-03-22	2002-04-02	Duke University	Methods of culturing and encapsulating pancreatic islet cells
US6303355B1 (en)	1999-03-22	2001-10-16	Duke University	Method of culturing, cryopreserving and encapsulating pancreatic islet cells
AU5632600A (en) *	1999-06-23	2001-01-09	Joslin Diabetes Center Inc.	Methods of making pancreatic islet cells
US6815203B1 (en)	1999-06-23	2004-11-09	Joslin Diabetes Center, Inc.	Methods of making pancreatic islet cells
EP1224259A4 (de) *	1999-09-27	2005-04-27	Univ Florida	Rückbildung von insulinabhängigem diabetes durch inselbildende stammzellen, inselvorläuferzellen und inselähnliche strukturen
US6828111B2 (en)	2000-01-13	2004-12-07	Wayne State University	Three-dimensional in vitro model of human preneoplastic breast disease
CA2442177A1 (en) *	2001-03-29	2002-10-10	Ixion Biotechnology, Inc.	Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
JP2005506074A (ja) *	2001-10-18	2005-03-03	イクシオン・バイオテクノロジー・インコーポレーテッド	肝臓の幹細胞および前駆細胞の膵臓機能細胞への転換
GB2399348A (en) *	2001-12-07	2004-09-15	Geron Corp	Chondrocyte precursors derived from human embryonic stem cells
IL162131A0 (en) *	2001-12-07	2005-11-20	Geron Corp	Islet cells from human embryonic stem cells
WO2003068357A2 (en) *	2002-02-12	2003-08-21	Cornell Research Foundation, Inc.	Identification and high-yield isolation of human pancreatic islet progenitor and stem cells
US20040175366A1 (en) *	2003-03-07	2004-09-09	Acell, Inc.	Scaffold for cell growth and differentiation
US20040176855A1 (en) *	2003-03-07	2004-09-09	Acell, Inc.	Decellularized liver for repair of tissue and treatment of organ deficiency
CA2520861A1 (en) *	2003-03-27	2004-10-14	Ixion Biotechnology, Inc.	Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway
EP1644011A1 (de) *	2003-06-25	2006-04-12	Stephen F. Badylak	Konditionierte matrix-zusammensetzungen zur gewebe-wiederherstellung
US8415153B2 (en)	2006-06-19	2013-04-09	Geron Corporation	Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US8298586B2 (en)	2009-07-22	2012-10-30	Acell Inc	Variable density tissue graft composition
US8652500B2 (en)	2009-07-22	2014-02-18	Acell, Inc.	Particulate tissue graft with components of differing density and methods of making and using the same
US9878071B2 (en)	2013-10-16	2018-01-30	Purdue Research Foundation	Collagen compositions and methods of use
JP2017529390A (ja)	2014-08-27	2017-10-05	パデューリサーチファウンデーションオフィスオブテクノロジーコマーシャリゼーション	コラーゲンに基づく治療送達系
US11919941B2 (en)	2015-04-21	2024-03-05	Purdue Research Foundation	Cell-collagen-silica composites and methods of making and using the same
JP7242553B2 (ja)	2017-01-31	2023-03-20	ジェニフィス，インコーポレイテッド	基質の調製のための方法及び組成物
US11739291B2 (en)	2017-04-25	2023-08-29	Purdue Research Foundation	3-dimensional (3D) tissue-engineered muscle for tissue restoration
KR102688254B1 (ko) *	2019-04-25	2024-07-25	두원중공업(주)	전동식 압축기
CA3168904A1 (en)	2020-01-27	2021-08-05	Geniphys, Inc.	Biologic filler for restoring and regenerating tissue

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2757169A1 (de) *	1977-12-22	1979-07-05	Hoechst Ag	Verfahren zur gewinnung insulin produzierender tierischer zellen
US4332893A (en) *	1980-06-13	1982-06-01	Rosenberg Ralph A	Process for the production of an insulin-producing cell line of pancreatic beta cells

1981
- 1981-10-21 US US06/313,494 patent/US4439521A/en not_active Expired - Lifetime
1982
- 1982-10-20 CA CA000413837A patent/CA1179956A/en not_active Expired
- 1982-10-21 AT AT82305595T patent/ATE12255T1/de not_active IP Right Cessation
- 1982-10-21 EP EP82305595A patent/EP0078153B1/de not_active Expired
- 1982-10-21 DE DE8282305595T patent/DE3262697D1/de not_active Expired
- 1982-10-21 JP JP57185346A patent/JPS58135815A/ja active Granted

Also Published As

Publication number	Publication date
JPS6237607B2 (de)	1987-08-13
CA1179956A (en)	1984-12-27
EP0078153B1 (de)	1985-03-20
JPS58135815A (ja)	1983-08-12
DE3262697D1 (en)	1985-04-25
EP0078153A3 (en)	1983-10-19
US4439521A (en)	1984-03-27
EP0078153A2 (de)	1983-05-04

Publication	Publication Date	Title
ATE12255T1 (de)	1985-04-15	Verfahren zur herstellung von selbstreproduzierenden pankreatischen inseln aehnlichen strukturen von saeugetieren.
DE69533223D1 (de)	2004-08-05	Zusammensetzungen und verfahren zur stimulierung der proliferation und der differenzierung von menschlichen fetalen und erwachsenen pankreatischen zellen ex vivo
DE69028514D1 (de)	1996-10-17	Leukämiehemmender faktor aus vieharten und seine verwendung zur verbesserung der implantation und der entwicklung von embryonalen zellen
ATE260971T1 (de)	2004-03-15	Verfahren zur in vitro kultivierung dendritischer vorläuferzellen und deren verwendung zur immunogen herstellung
ATE202688T1 (de)	2001-07-15	In vitro herstellung eines kornea aequivalenten modells
DE3853201D1 (de)	1995-04-06	Schimäre immunkompromittierende Säugetiere und ihre Verwendung.
DE69536014D1 (de)	2009-12-10	Verfahren zur herstellung angereicherter hämatopoietischer zusammensetzungen, dadurch hergestellte zusammensetzungen sowie deren verwendungen
ATE67787T1 (de)	1991-10-15	Verfahren zur herstellung von proteinen mittels induzierbarer expressionssysteme in in-vivovermehrten, genetisch modifizierten eukaryotischen wirtszellen.
DE59913565D1 (de)	2006-07-27	Rekombinanter stabiler zellklon, seine herstellung und verwendung
ATE97448T1 (de)	1993-12-15	Verfahren zur isolierung von ca 125-antigen.
Malemud et al.	1978	Explant culture of human and rabbit articular chondrocytes
FI894001A0 (fi)	1989-08-25	Vaextgummimaterial och dess anvaendning i livsmedelsprodukter.
KR880007714A (ko)	1988-08-29	구군 식물의 증식방법
ATE258223T1 (de)	2004-02-15	Saccharose-phosphat-synthase (sps), ihr verfahren zur herstellung, ihr cdna und verwendung von cdna zur veränderung der sps-expression in pflanzenzellen
CA2177043A1 (en)	1995-05-26	Hepatoblasts and method of isolating same
ATE10806T1 (de)	1985-01-15	Verfahren zur herstellung von hepatitis boberfl[chenantigen.
EP0310056A3 (de)	1989-06-14	T-Zellen-Wachstumsfaktor aus Thymusdrüsen-Stroma und Verfahren zu seiner Herstellung
Bohn	1975	Growth-promoting effect of haemocytes on insect epidermis in vitro
ATE207139T1 (de)	2001-11-15	Verfahren zur herstellung von butantetracarbonsäure
Slavinski et al.	1974	Propagation in vitro of functional rat adrenal cortical cells: modifications of the differentiated state by culture conditions
ATE193556T1 (de)	2000-06-15	Verfahren zur herstellung von melaninpigmente durch biokonversion
Biesele et al.	1955	A study of cytoplasmic lipid granularity in tissue culture cells
JPS5774093A (en)	1982-05-10	Method of increasing interferon production
Lefkowitz et al.	1956	The cultivation of tooth germs in an embryo extract-free medium
ATE2339T1 (de)	1983-02-15	Verfahren zur herstellung von sphingomyelinase, sphingomyelinase und deren verwendung.

Legal Events

Date	Code	Title	Description
1985-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties