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ATE118040T1 - Thermostabile cytosin deaminase. - Google Patents

Thermostabile cytosin deaminase.

Info

Publication number
ATE118040T1
ATE118040T1 AT90306131T AT90306131T ATE118040T1 AT E118040 T1 ATE118040 T1 AT E118040T1 AT 90306131 T AT90306131 T AT 90306131T AT 90306131 T AT90306131 T AT 90306131T AT E118040 T1 ATE118040 T1 AT E118040T1
Authority
AT
Austria
Prior art keywords
cdase
thermally stable
cytosine deaminase
kda
molecular weight
Prior art date
Application number
AT90306131T
Other languages
English (en)
Inventor
Peter Dana Senter
Peter Chong-Dug Su
Hans Marquardt
Martha S Hayden
Peter Linsley
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/531,646 external-priority patent/US5338678A/en
Application filed by Oncogen filed Critical Oncogen
Application granted granted Critical
Publication of ATE118040T1 publication Critical patent/ATE118040T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT90306131T 1989-06-09 1990-06-06 Thermostabile cytosin deaminase. ATE118040T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36502089A 1989-06-09 1989-06-09
US07/531,646 US5338678A (en) 1989-06-09 1990-06-01 Expression of DNA sequences encoding a thermally stable cytosine deaminase from saccharomyces

Publications (1)

Publication Number Publication Date
ATE118040T1 true ATE118040T1 (de) 1995-02-15

Family

ID=27002759

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90306131T ATE118040T1 (de) 1989-06-09 1990-06-06 Thermostabile cytosin deaminase.

Country Status (21)

Country Link
US (1) US5545548A (de)
EP (1) EP0402108B1 (de)
JP (1) JP3001933B2 (de)
CN (1) CN1052263C (de)
AT (1) ATE118040T1 (de)
CA (1) CA2018273C (de)
CZ (1) CZ283492B6 (de)
DE (1) DE69016502T2 (de)
DK (1) DK0402108T3 (de)
ES (1) ES2070277T3 (de)
FI (1) FI95046C (de)
GR (1) GR3015207T3 (de)
IE (1) IE66054B1 (de)
IL (1) IL94649A (de)
MY (1) MY105816A (de)
NO (1) NO301487B1 (de)
NZ (1) NZ233949A (de)
OA (1) OA09214A (de)
PL (1) PL165149B1 (de)
PT (1) PT94331B (de)
YU (1) YU112090A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555370B1 (en) 1990-11-13 2003-04-29 Immunex Corporation Bifunctional selectable fusion genes
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
EP0804590A1 (de) * 1993-05-21 1997-11-05 Targeted Genetics Corporation Bifunktionelle selektierbare fusionsgene auf dem cytosin-deaminase (cd) gen beruhend
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
US5856153A (en) * 1994-11-17 1999-01-05 Cayla Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases
CA2243985C (en) * 1997-09-11 2004-08-10 F. Hoffmann-La Roche Ag Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
GB9810752D0 (en) * 1998-05-19 1998-07-15 Glaxo Group Ltd Cystosine deaminase gene
US6962702B2 (en) 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
US6656917B1 (en) 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
CA2491310C (en) 2002-07-15 2015-10-06 Board Of Regents, The University Of Texas System Compositions comprising cell-impermeant duramycin derivatives
EP1897938B9 (de) * 2003-07-21 2011-08-31 Transgene SA Polypeptid mit einer verbesserten Zytosindeaminase-Aktivität
DE602004031681D1 (de) 2003-07-21 2011-04-14 Transgene Sa Multifunktionelle Cytokine
EP2216342B1 (de) 2003-07-31 2015-04-22 Immunomedics, Inc. Anti-CD19 Antikörper
WO2005086922A2 (en) * 2004-03-10 2005-09-22 Board Of Regents, University Of Texas System Oncolytic adenovirus armed with therapeutic genes
JP4663631B2 (ja) * 2004-04-28 2011-04-06 天野エンザイム株式会社 放線菌由来のａｍｐデアミナーゼ及びその利用
JP5809415B2 (ja) 2007-11-09 2015-11-10 ペレグリン ファーマシューティカルズ，インコーポレーテッド 抗ｖｅｇｆ抗体の組成物および方法
US20090263884A1 (en) * 2008-04-22 2009-10-22 Organica Biotech, Inc. Multi-action drain cleaning composition and method
WO2010045002A2 (en) 2008-09-26 2010-04-22 Tocagen Inc. Gene therapy vectors and cytosine deaminases
CN103045573B (zh) * 2012-12-10 2015-03-18 浙江工业大学 冬虫夏草胞嘧啶脱氨酶、编码基因及其应用
CN103031296B (zh) * 2012-12-10 2014-12-17 浙江工业大学 冬虫夏草dCMP脱氨酶、编码基因及其应用
CN109207535B (zh) * 2018-09-20 2021-06-25 新乡拓新药业股份有限公司 利用铜绿假单胞菌合成尿嘧啶的方法
CN116143947B (zh) * 2023-01-16 2024-05-24 中国科学院青岛生物能源与过程研究所 一种酵母胞嘧啶脱氨酶融合蛋白及其突变体和应用

Also Published As

Publication number Publication date
IL94649A (en) 1995-11-27
PL165149B1 (pl) 1994-11-30
CN1050221A (zh) 1991-03-27
DK0402108T3 (da) 1995-04-10
CA2018273A1 (en) 1990-12-09
DE69016502D1 (de) 1995-03-16
JP3001933B2 (ja) 2000-01-24
CZ283492B6 (cs) 1998-04-15
NO902551L (no) 1990-12-10
FI902855A0 (fi) 1990-06-07
FI95046B (fi) 1995-08-31
PT94331B (pt) 1997-04-30
PT94331A (pt) 1991-03-20
YU112090A (en) 1992-05-28
IE902079L (en) 1990-12-09
FI95046C (fi) 1995-12-11
DE69016502T2 (de) 1995-06-01
ES2070277T3 (es) 1995-06-01
IL94649A0 (en) 1991-04-15
MY105816A (en) 1995-01-30
JPH04131084A (ja) 1992-05-01
PL285552A1 (en) 1991-02-25
OA09214A (en) 1992-06-30
NZ233949A (en) 1992-06-25
EP0402108A1 (de) 1990-12-12
EP0402108B1 (de) 1995-02-01
NO902551D0 (no) 1990-06-08
IE66054B1 (en) 1995-12-13
CS286590A3 (en) 1992-02-19
CN1052263C (zh) 2000-05-10
NO301487B1 (no) 1997-11-03
CA2018273C (en) 1999-04-06
US5545548A (en) 1996-08-13
GR3015207T3 (en) 1995-05-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time