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ATE116316T1 - Antipsychotische 4-(1,2- benzisoazolyl)piperidinderivate. - Google Patents

Antipsychotische 4-(1,2- benzisoazolyl)piperidinderivate.

Info

Publication number
ATE116316T1
ATE116316T1 AT91915887T AT91915887T ATE116316T1 AT E116316 T1 ATE116316 T1 AT E116316T1 AT 91915887 T AT91915887 T AT 91915887T AT 91915887 T AT91915887 T AT 91915887T AT E116316 T1 ATE116316 T1 AT E116316T1
Authority
AT
Austria
Prior art keywords
benzisoazolyl
antipsychotic
piperidine derivatives
piperidine
benzisoxazolyl
Prior art date
Application number
AT91915887T
Other languages
English (en)
Inventor
Harry Ralph Howard Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE116316T1 publication Critical patent/ATE116316T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT91915887T 1990-11-14 1991-08-16 Antipsychotische 4-(1,2- benzisoazolyl)piperidinderivate. ATE116316T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/612,776 US5147881A (en) 1990-11-14 1990-11-14 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents

Publications (1)

Publication Number Publication Date
ATE116316T1 true ATE116316T1 (de) 1995-01-15

Family

ID=24454621

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915887T ATE116316T1 (de) 1990-11-14 1991-08-16 Antipsychotische 4-(1,2- benzisoazolyl)piperidinderivate.

Country Status (10)

Country Link
US (3) US5147881A (de)
EP (1) EP0557289B1 (de)
JP (1) JPH05507281A (de)
AT (1) ATE116316T1 (de)
CA (1) CA2094246A1 (de)
DE (1) DE69106388T2 (de)
FI (1) FI932173A0 (de)
IE (1) IE913940A1 (de)
PT (1) PT99482A (de)
WO (1) WO1992008718A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
AU669156B2 (en) * 1992-02-13 1996-05-30 Merrell Dow Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
DK0669920T3 (da) * 1992-11-23 2003-05-26 Aventis Pharma Inc Substituerede 3-(aminoalkylamino)-1,2-benzisoxazoler og beslægtede forbindelser
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
DK60493D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
FR2761067B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
JP4806149B2 (ja) * 1999-09-14 2011-11-02 アベンティスユービー・セカンド・インコーポレイテッド Ｄ４拮抗薬として有用なベンズイソオキサゾリル−、ピリドイソオキサゾリル−、及びベンズチエニル−フェノキシ誘導体
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
KR20050057404A (ko) * 2002-09-17 2005-06-16 워너-램버트 캄파니 엘엘씨 정신분열증 치료용 헤테로환 치환된 피페라진
US20070185168A1 (en) * 2004-04-07 2007-08-09 Takai Haruki S Piperidine derivatives
EP2322520A4 (de) * 2008-07-28 2012-04-25 Jiangsu Guohua Invest Co Ltd Aralkylsubstituierte piperidin- oder piperazinderivate und deren verwendung zur behandlung von schizophrenie
EP3610890A1 (de) 2012-11-14 2020-02-19 The Johns Hopkins University Verfahren und zusammensetzungen zur behandlung von schizophrenie
JP5714152B2 (ja) * 2014-03-26 2015-05-07 江蘇恒誼薬業有限公司 アラルキルピペリジン（又はピペラジン）誘導体及びその統合失調症治療のための使用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS5846079A (ja) * 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
FR2536749A1 (fr) * 1982-11-25 1984-06-01 Cerm Cent Europ Rech Mauvernay (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB2176474A (en) * 1985-06-15 1986-12-31 Tanabe Seiyaku Co Thiazolidine derivatives
GB8531666D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2621588B1 (fr) * 1987-10-08 1991-05-24 Roussel Uclaf Nouveaux derives de la 1,1-dioxo 1,2-benzoisothiazol 3-one, leur procede de preparation et leur application comme medicaments
GB8726763D0 (en) * 1987-11-16 1987-12-23 Fujisawa Pharmaceutical Co Thiazole compounds
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5034392A (en) * 1990-04-16 1991-07-23 Hoechst-Roussel Pharmaceuticals Incorporated 4-(3-(4-oxothiazolidinyl)butynylamines

Also Published As

Publication number Publication date
JPH05507281A (ja) 1993-10-21
DE69106388D1 (de) 1995-02-09
US5385916A (en) 1995-01-31
US5276040A (en) 1994-01-04
IE913940A1 (en) 1992-05-20
EP0557289B1 (de) 1994-12-28
FI932173A7 (fi) 1993-05-13
WO1992008718A1 (en) 1992-05-29
PT99482A (pt) 1992-09-30
EP0557289A1 (de) 1993-09-01
FI932173L (fi) 1993-05-13
DE69106388T2 (de) 1995-05-04
FI932173A0 (fi) 1993-05-13
CA2094246A1 (en) 1992-05-15
US5147881A (en) 1992-09-15

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties