ATE114118T1 - System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren. - Google Patents
System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren.Info
- Publication number
- ATE114118T1 ATE114118T1 AT91911198T AT91911198T ATE114118T1 AT E114118 T1 ATE114118 T1 AT E114118T1 AT 91911198 T AT91911198 T AT 91911198T AT 91911198 T AT91911198 T AT 91911198T AT E114118 T1 ATE114118 T1 AT E114118T1
- Authority
- AT
- Austria
- Prior art keywords
- level
- current
- iontophoretic
- agent
- drug delivery
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50217690A | 1990-03-30 | 1990-03-30 | |
US07/671,306 US5207752A (en) | 1990-03-30 | 1991-03-21 | Iontophoretic drug delivery system with two-stage delivery profile |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE114118T1 true ATE114118T1 (de) | 1994-12-15 |
Family
ID=27054046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91911198T ATE114118T1 (de) | 1990-03-30 | 1991-03-22 | System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5207752A (de) |
EP (1) | EP0522092B1 (de) |
JP (1) | JP3181289B2 (de) |
KR (1) | KR0169084B1 (de) |
AT (1) | ATE114118T1 (de) |
AU (1) | AU638581B2 (de) |
CA (1) | CA2079316C (de) |
DE (1) | DE69105202T2 (de) |
DK (1) | DK0522092T3 (de) |
ES (1) | ES2067939T3 (de) |
FI (1) | FI110066B (de) |
GR (1) | GR3015116T3 (de) |
NO (1) | NO308025B1 (de) |
WO (1) | WO1991015258A1 (de) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2121372C (en) * | 1991-12-03 | 2003-02-04 | Ronald P. Haak | Iontophoretic delivery device and power supply therefor |
US5505715A (en) * | 1994-02-25 | 1996-04-09 | Bristol-Myers Squibb Company | Iontophoretic transdermal delivery of deoxyspergualin compounds |
US7027859B1 (en) | 1994-09-26 | 2006-04-11 | Alza Corporation | Electrotransport delivery device having improved safety and reduced abuse potential |
US5697896A (en) * | 1994-12-08 | 1997-12-16 | Alza Corporation | Electrotransport delivery device |
US5700481A (en) * | 1995-03-17 | 1997-12-23 | Takeda Chemical Industries, Ltd. | Transdermal drug delivery process |
EP0819016A1 (de) * | 1995-04-07 | 1998-01-21 | Novartis AG | Iontophoretisches transdermales system zum verabreichen von mindestens zwei substanzen |
IE960312A1 (en) * | 1995-06-02 | 1996-12-11 | Alza Corp | An electrotransport delivery device with voltage boosting¹circuit |
US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
AU710793B2 (en) * | 1995-06-07 | 1999-09-30 | Alza Corporation | Electrotransport agent delivery method and apparatus |
WO1997014473A1 (en) * | 1995-10-18 | 1997-04-24 | Novartis Ag | Thermopile powered transdermal drug delivery device |
US6718201B1 (en) * | 1996-06-07 | 2004-04-06 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US5961483A (en) * | 1996-06-19 | 1999-10-05 | Sage; Burton H. | Iontophoretic delivery of cell adhesion inhibitors |
US5857994A (en) * | 1996-10-01 | 1999-01-12 | Becton, Dickinson And Company | Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof |
FR2766093B1 (fr) * | 1997-07-15 | 1999-09-03 | Lhd Lab Hygiene Dietetique | Procede de commande d'un dispositif d'administration transdermique de medicament sous champ electrique |
KR20010033208A (ko) | 1997-12-16 | 2001-04-25 | 스톤 스티븐 에프. | 조정된 이송을 유지하기위해 인공 부하를 갖는 조정기 |
ES2281940T3 (es) | 1997-12-17 | 2007-10-01 | Alza Corporation | Iontoforesis con ajuste programado de la corriente electrica. |
HU222513B1 (hu) | 1998-01-30 | 2003-08-28 | Novo Nordisk A/S | Injekciós fecskendő |
WO2000047274A1 (en) | 1999-02-10 | 2000-08-17 | Gmp Drug Delivery, Inc. | Iontophoresis, electroporation and combination patches for local drug delivery |
US6471675B1 (en) | 1999-04-30 | 2002-10-29 | Medtronic, Inc. | Passive flow control devices for implantable pumps |
TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
WO2002036072A2 (en) * | 2000-11-03 | 2002-05-10 | Biomedicines, Inc. | Method for short-term and long-term drug dosimetry |
ATE481135T1 (de) * | 2001-11-09 | 2010-10-15 | Intarcia Therapeutics Inc | Kombinationstherapie mit omega-interferon zur behandlung von hepatitis c virus oder gelbfieber virus infektionen |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
GB0304822D0 (en) * | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
EP2210634A1 (de) * | 2009-01-22 | 2010-07-28 | Sanofi-Aventis Deutschland GmbH | Dosierungseinstellungsmechanismus für Arzneimittelabgabevorrichtung |
GB0308267D0 (en) * | 2003-04-10 | 2003-05-14 | Dca Design Int Ltd | Improvements in and relating to a pen-type injector |
US7220778B2 (en) * | 2003-04-15 | 2007-05-22 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
US7596407B2 (en) * | 2004-03-26 | 2009-09-29 | Solvay Pharmaceuticals, B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
EP1595542A1 (de) * | 2004-03-26 | 2005-11-16 | Solvay Pharmaceuticals B.V. | Transdermale iontophoretische Verabreichung von Piperazinyl-2(3H)-benzoxazolon-Verbindungen |
DE602005016952D1 (de) | 2004-10-21 | 2009-11-12 | Novo Nordisk As | Wählmechanismus für einen drehstift |
US8052996B2 (en) | 2005-02-03 | 2011-11-08 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US20080208142A1 (en) * | 2005-02-28 | 2008-08-28 | Novo Nordisk A/S | Dose Setting Mechanism for an Injection Device |
US7856263B2 (en) | 2005-04-22 | 2010-12-21 | Travanti Pharma Inc. | Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis |
JP4979686B2 (ja) | 2005-04-24 | 2012-07-18 | ノボ・ノルデイスク・エー/エス | 注入デバイス |
US20070093788A1 (en) * | 2005-09-30 | 2007-04-26 | Darrick Carter | Iontophoresis method and apparatus for systemic delivery of active agents |
WO2007046103A2 (en) * | 2005-10-19 | 2007-04-26 | Perf-Action Technologies Ltd. | System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof |
EP1996259B1 (de) | 2006-03-10 | 2012-08-15 | Novo Nordisk A/S | Injiziervorrichtung und verfahren zum wechseln einer patrone in der vorrichtung |
CN101400394B (zh) | 2006-03-10 | 2012-07-04 | 诺沃-诺迪斯克有限公司 | 具有传动部件的注射装置 |
JP5580042B2 (ja) * | 2006-04-13 | 2014-08-27 | ヌパス インコーポレイテッド | 抗片頭痛化合物の送達のための経皮的方法およびシステム |
AU2012261753B2 (en) * | 2006-04-13 | 2015-03-05 | Teva Pharmaceuticals International Gmbh | Transdermal methods and systems for the delivery of anti-migraine compounds |
WO2007132526A1 (ja) * | 2006-05-16 | 2007-11-22 | Rorze Corporation | シャトル型搬送装置、マイクロプレート供給回収装置、マイクロプレート用ピックアップ装置、マイクロプレート用カセット、及びマイクロプレート用収納棚 |
US8226618B2 (en) * | 2006-05-16 | 2012-07-24 | Novo Nordisk A/S | Gearing mechanism for an injection device |
EP2374488B1 (de) | 2006-05-18 | 2018-03-21 | Novo Nordisk A/S | Injektionsvorrichtung mit Modussperrmöglichkeiten |
PT2359808E (pt) | 2006-08-09 | 2013-08-28 | Intarcia Therapeutics Inc | Sistemas de entrega osmótica e montagens de pistão |
US8728059B2 (en) * | 2006-09-29 | 2014-05-20 | Covidien Lp | System and method for assuring validity of monitoring parameter in combination with a therapeutic device |
EP2109474B2 (de) | 2007-02-05 | 2019-01-30 | Novo Nordisk A/S | Injektionsknopf |
US8353878B2 (en) | 2007-03-23 | 2013-01-15 | Novo Nordisk A/S | Injection device comprising a locking nut |
PL2157967T3 (pl) | 2007-04-23 | 2013-06-28 | Intarcia Therapeutics Inc | Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
CA2724949A1 (en) * | 2007-06-27 | 2008-12-31 | The General Hospital Corporation | Method and apparatus for optical inhibition of photodynamic therapy |
US20090043244A1 (en) * | 2007-08-08 | 2009-02-12 | Inan Omer T | Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US20090259176A1 (en) * | 2008-04-09 | 2009-10-15 | Los Gatos Research, Inc. | Transdermal patch system |
US20090312689A1 (en) * | 2008-06-05 | 2009-12-17 | Alza Corporation | Adjustable Current Electrotransport Fentanyl Delivery Device |
US8366600B2 (en) * | 2008-06-19 | 2013-02-05 | Nupathe Inc. | Polyamine enhanced formulations for triptan compound iontophoresis |
US8155737B2 (en) * | 2008-06-19 | 2012-04-10 | Nupathe, Inc. | Pharmacokinetics of iontophoretic sumatriptan administration |
NZ622157A (en) * | 2008-12-30 | 2015-10-30 | Teva Pharmaceuticals Int Gmbh | Electronic control of drug delivery system |
US8961492B2 (en) | 2009-02-12 | 2015-02-24 | Incube Labs, Llc | System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation |
US9008765B2 (en) | 2009-02-12 | 2015-04-14 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings |
US8190252B2 (en) | 2009-02-12 | 2012-05-29 | Incube Labs, Llc | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes |
US8903485B2 (en) | 2009-08-06 | 2014-12-02 | Incube Labs, Llc | Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes |
JP6116246B2 (ja) | 2009-08-10 | 2017-04-19 | テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー | イオントフォレシスにより悪心および片頭痛を治療するための方法 |
HUE035862T2 (en) | 2009-09-28 | 2018-05-28 | Intarcia Therapeutics Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
WO2011046927A1 (en) * | 2009-10-13 | 2011-04-21 | Nupathe,Inc. | Transdermal methods and systems for the delivery of rizatriptan |
US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
US8986279B2 (en) | 2010-02-10 | 2015-03-24 | Incube Labs, Llc | Methods and architecture for power optimization of iontophoretic transdermal drug delivery |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
CN106955415B (zh) | 2011-03-24 | 2019-06-18 | 因卡伯实验室有限责任公司 | 用于治疗剂的两阶段经皮离子电渗递送的系统及方法 |
US8428709B1 (en) | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
US8428708B1 (en) * | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
MX2014007375A (es) | 2011-12-29 | 2014-08-22 | Novo Nordisk As | Jeringa autoinyectora de cuerda basada en resorte de torsion con mecanismo dosificador giratorio de aumento/disminucion. |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
MX2017015504A (es) | 2015-06-03 | 2018-05-15 | Intarcia Therapeutics Inc | Sistemas de colocacion y remoción de implante. |
CA3024479A1 (en) | 2016-05-16 | 2017-11-23 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
CN118903385A (zh) | 2017-08-24 | 2024-11-08 | 诺和诺德股份有限公司 | Glp-1组合物及其用途 |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
PE20230819A1 (es) | 2020-02-18 | 2023-05-19 | Novo Nordisk As | Composiciones y usos de glp-1 |
Family Cites Families (34)
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US3163166A (en) * | 1961-04-28 | 1964-12-29 | Colgate Palmolive Co | Iontophoresis apparatus |
US3618601A (en) * | 1969-10-16 | 1971-11-09 | Thatcher W Richardson | Iontophoresis unit |
US3677268A (en) * | 1969-11-28 | 1972-07-18 | Sherwood Medical Ind Inc | Iontophoresis electrode |
US3794910A (en) * | 1971-07-26 | 1974-02-26 | Sherwood Medical Ind Inc | Iontophoresis and conductivity analysis circuit |
DE2339648C3 (de) * | 1973-08-04 | 1979-09-13 | Trebbin, Peter, 8833 Eichstaett | Anästhesiegerät zur Behandlung der Zähne |
US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
US4211222A (en) * | 1976-08-25 | 1980-07-08 | Robert Tapper | Iontophoretic burn-protection method |
JPS5347192A (en) * | 1976-10-13 | 1978-04-27 | Matsushita Electric Ind Co Ltd | Device for introducing fluorine ion to tooth |
US4325367A (en) * | 1977-06-13 | 1982-04-20 | Robert Tapper | Iontophoretic treatment apparatus |
US4177817A (en) * | 1978-02-01 | 1979-12-11 | C. R. Bard, Inc. | Dual terminal transcutaneous electrode |
US4215696A (en) * | 1978-03-20 | 1980-08-05 | Graphic Controls Corporation | Biomedical electrode with pressurized skin contact |
US4209020A (en) * | 1978-09-19 | 1980-06-24 | Nielsen R Frederick | Electrode assembly |
US4301794A (en) * | 1978-10-18 | 1981-11-24 | Robert Tapper | Method for iontophoretic treatment |
US4340047A (en) * | 1978-10-18 | 1982-07-20 | Robert Tapper | Iontophoretic treatment apparatus |
US4292968A (en) * | 1979-11-26 | 1981-10-06 | Sybron Corporation | Electric supply for ion therapy |
AU546785B2 (en) * | 1980-07-23 | 1985-09-19 | Commonwealth Of Australia, The | Open-loop controlled infusion of diabetics |
JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
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AU577731B2 (en) * | 1983-04-15 | 1988-09-29 | Jack Kenneth Ibbott | Therapeutic method and appliance employing flat battery |
US4557723A (en) * | 1983-08-18 | 1985-12-10 | Drug Delivery Systems Inc. | Applicator for the non-invasive transcutaneous delivery of medicament |
US4731926A (en) * | 1985-02-19 | 1988-03-22 | Drug Delivery Systems Inc. | Method of manufacturing disposable and/or replenishable transdermal drug applicators |
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MX168630B (es) * | 1985-06-10 | 1993-06-02 | Drug Delivery Systems Inc | Sistema y metodo para controlar la tasa de liberacion electrocinetica de un medicamento |
US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
US4725263A (en) * | 1986-07-31 | 1988-02-16 | Medtronic, Inc. | Programmable constant current source transdermal drug delivery system |
US4822334A (en) * | 1986-12-04 | 1989-04-18 | Robert Tapper | Electrical dosimetry control system |
US4731049A (en) * | 1987-01-30 | 1988-03-15 | Ionics, Incorporated | Cell for electrically controlled transdermal drug delivery |
JPH02500339A (ja) * | 1987-05-15 | 1990-02-08 | ニューマン,マーティン・エッチ | イオン浸透薬剤供給装置 |
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-
1991
- 1991-03-21 US US07/671,306 patent/US5207752A/en not_active Expired - Lifetime
- 1991-03-22 KR KR1019920702381A patent/KR0169084B1/ko not_active Expired - Fee Related
- 1991-03-22 AU AU79915/91A patent/AU638581B2/en not_active Expired
- 1991-03-22 EP EP91911198A patent/EP0522092B1/de not_active Revoked
- 1991-03-22 ES ES91911198T patent/ES2067939T3/es not_active Expired - Lifetime
- 1991-03-22 DE DE69105202T patent/DE69105202T2/de not_active Expired - Fee Related
- 1991-03-22 DK DK91911198.9T patent/DK0522092T3/da active
- 1991-03-22 JP JP51059091A patent/JP3181289B2/ja not_active Expired - Lifetime
- 1991-03-22 AT AT91911198T patent/ATE114118T1/de not_active IP Right Cessation
- 1991-03-22 CA CA002079316A patent/CA2079316C/en not_active Expired - Lifetime
- 1991-03-22 WO PCT/US1991/001941 patent/WO1991015258A1/en active IP Right Grant
-
1992
- 1992-09-28 NO NO923769A patent/NO308025B1/no not_active IP Right Cessation
- 1992-09-28 FI FI924352A patent/FI110066B/fi active
-
1995
- 1995-02-20 GR GR950400340T patent/GR3015116T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI110066B (fi) | 2002-11-29 |
FI924352L (fi) | 1992-09-28 |
US5207752A (en) | 1993-05-04 |
DK0522092T3 (da) | 1995-03-13 |
WO1991015258A1 (en) | 1991-10-17 |
EP0522092B1 (de) | 1994-11-17 |
CA2079316C (en) | 2002-01-01 |
NO308025B1 (no) | 2000-07-10 |
AU7991591A (en) | 1991-10-30 |
JPH05505964A (ja) | 1993-09-02 |
JP3181289B2 (ja) | 2001-07-03 |
GR3015116T3 (en) | 1995-05-31 |
NO923769L (no) | 1992-11-30 |
NO923769D0 (no) | 1992-09-28 |
EP0522092A1 (de) | 1993-01-13 |
KR0169084B1 (ko) | 1999-01-15 |
CA2079316A1 (en) | 1991-10-01 |
DE69105202T2 (de) | 1995-03-23 |
DE69105202D1 (de) | 1994-12-22 |
KR930700181A (ko) | 1993-03-13 |
AU638581B2 (en) | 1993-07-01 |
FI924352A0 (fi) | 1992-09-28 |
ES2067939T3 (es) | 1995-04-01 |
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