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ATA292885A - Verfahren zur herstellung von diphosphonsaeuren - Google Patents

Verfahren zur herstellung von diphosphonsaeuren

Info

Publication number
ATA292885A
ATA292885A AT852928A AT292885A ATA292885A AT A292885 A ATA292885 A AT A292885A AT 852928 A AT852928 A AT 852928A AT 292885 A AT292885 A AT 292885A AT A292885 A ATA292885 A AT A292885A
Authority
AT
Austria
Prior art keywords
producing
diphosphonic acids
diphosphonic
acids
producing diphosphonic
Prior art date
Application number
AT852928A
Other languages
English (en)
Other versions
AT391702B (de
Inventor
Giorgio Staibano
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of ATA292885A publication Critical patent/ATA292885A/de
Application granted granted Critical
Publication of AT391702B publication Critical patent/AT391702B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT0292885A 1984-10-29 1985-10-10 Verfahren zur herstellung von diphosphonsaeuren AT391702B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23362/84A IT1196315B (it) 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici

Publications (2)

Publication Number Publication Date
ATA292885A true ATA292885A (de) 1990-05-15
AT391702B AT391702B (de) 1990-11-26

Family

ID=11206414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0292885A AT391702B (de) 1984-10-29 1985-10-10 Verfahren zur herstellung von diphosphonsaeuren

Country Status (13)

Country Link
US (1) US4705651A (de)
JP (1) JPS61109794A (de)
AT (1) AT391702B (de)
BE (1) BE903519A (de)
CH (1) CH663791A5 (de)
DE (1) DE3535404A1 (de)
FR (1) FR2572406B1 (de)
GB (1) GB2166741B (de)
HK (1) HK12891A (de)
IT (1) IT1196315B (de)
LU (1) LU86133A1 (de)
NL (1) NL193945C (de)
SE (1) SE464084B (de)

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DE3700772A1 (de) * 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
GB8825589D0 (en) * 1988-11-02 1988-12-07 Albright & Wilson Purification
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5183815A (en) * 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH0736804U (ja) * 1993-12-25 1995-07-11 松本 純子 指圧クッションシート
US5773429A (en) * 1996-12-11 1998-06-30 Fuisz Technologies Ltd. Drug combination for treating calcium loss
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
AU5698899A (en) 1998-08-27 2000-03-21 Teva Pharmaceutical Industries Ltd. Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
PT1169326E (pt) * 1999-02-17 2004-10-29 Teva Pharma Novo processo para a preparacao de acido alendronico
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
ES2153794B1 (es) 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
US7674480B2 (en) * 2000-06-23 2010-03-09 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US6881420B2 (en) 2000-06-23 2005-04-19 Teva Pharmaceutical Industries Ltd. Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
DE60235085D1 (de) 2001-07-16 2010-03-04 Univ Paris Xiii Herstellungsverfahren von derivate von bisphosphonaten
RU2294203C2 (ru) * 2001-12-21 2007-02-27 Дзе Проктер Энд Гэмбл Компани Способ лечения костных нарушений
KR20120065435A (ko) * 2002-05-10 2012-06-20 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
WO2003097655A1 (en) * 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
JP4427453B2 (ja) * 2002-12-20 2010-03-10 エフ．ホフマン−ラ ロシュ アーゲー 高用量イバンドロネート製剤
CN1325506C (zh) * 2003-05-15 2007-07-11 中国科学院上海药物研究所 骨重吸收抑制剂阿伦膦酸及生理可接受的盐和它的制备
ES2337063T3 (es) * 2003-08-21 2010-04-20 Sun Pharmaceuticals Industries Ltd. Proceso para la preparacion de acido bisfosfonico.
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
US20080069901A1 (en) * 2004-12-10 2008-03-20 Tmrc Co. , Ltd. Therapeutic Agent for Metastatic Cancer and Cancer Metastasis Inhibitor
CN1304401C (zh) * 2004-12-28 2007-03-14 浙江工业大学 一种阿伦膦酸的制备方法
EP1865967A4 (de) * 2005-04-08 2011-02-09 Chimerix Inc Verbindungen, zusammensetzungen und verfahren zur behandlung viraler infektionen und anderer erkrankungen
JP2008535862A (ja) 2005-04-08 2008-09-04 キメリクス，インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
PT1803727E (pt) * 2005-12-27 2009-06-15 Ipca Lab Ltd Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CN105055432A (zh) * 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
US7964584B2 (en) * 2008-08-01 2011-06-21 Dong Wha Pharmaceutical Co., Ltd. Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
TR200900880A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
CA2770282A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
PL2534150T3 (pl) 2010-02-12 2017-09-29 Chimerix, Inc. Sposoby leczenia infekcji wirusowej
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes
TR201100153A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Efervesan bifosfonat formülasyonları.
EP2661262B1 (de) 2011-01-06 2017-11-15 Mahmut Bilgic Verbesserte bisphosphonat-formulierungen
EP3105238A4 (de) 2014-02-13 2017-11-08 Ligand Pharmaceuticals, Inc. Organische verbindungen und deren verwendungen
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060546A (en) * 1961-07-03 1977-11-29 Henkel Kommanditgesellschaft Auf Aktien Process for the manufacture of acylation products of phosphorous acid
US3366677A (en) * 1965-05-13 1968-01-30 Procter & Gamble Low temperature preparation of ethane-1-hydroxy-1, 1-diphosphonic acid
DE2130794C3 (de) * 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2702631A1 (de) * 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2846835A1 (de) * 1978-10-27 1980-05-08 Benckiser Knapsack Gmbh Verfahren zur herstellung von carboxylalkan-aminoalkan-diphosphonsaeuren und -aminoarylalkan-diphosphonsaeuren
SU783300A1 (ru) * 1978-12-05 1980-11-30 Предприятие П/Я А-7346 Способ получени оксиэтилидендифосфоновой кислоты
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
GB2082585A (en) * 1980-08-27 1982-03-10 Vysoka Skola Chem Tech 6-amino-1-hydroxyhexylidene diphosphonic acid, salts thereof and a method of producing the acid and salts.
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3151038A1 (de) * 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure

Also Published As

Publication number Publication date
GB2166741B (en) 1988-07-20
GB8524428D0 (en) 1985-11-06
CH663791A5 (it) 1988-01-15
JPH0569110B2 (de) 1993-09-30
LU86133A1 (fr) 1986-03-24
HK12891A (en) 1991-03-08
JPS61109794A (ja) 1986-05-28
NL193945B (nl) 2000-11-01
SE464084B (sv) 1991-03-04
AT391702B (de) 1990-11-26
IT8423362A0 (it) 1984-10-29
NL193945C (nl) 2001-03-02
FR2572406A1 (fr) 1986-05-02
GB2166741A (en) 1986-05-14
US4705651A (en) 1987-11-10
NL8502949A (nl) 1986-05-16
BE903519A (nl) 1986-02-17
FR2572406B1 (fr) 1989-04-07
DE3535404A1 (de) 1986-04-30
DE3535404C2 (de) 1989-04-20
SE8504687L (sv) 1986-04-30
IT8423362A1 (it) 1986-04-29
IT1196315B (it) 1988-11-16
SE8504687D0 (sv) 1985-10-09

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Legal Events

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ELA Expired due to lapse of time