AT354448B - Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen - Google Patents

Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen

Info

Publication number: AT354448B
Authority: AT; Austria
Prior art keywords: isomers; mixtures; salts; producing new; pure stereo
Prior art date: 1975-08-09

Application number

AT586876A

Other languages

English (en)

Other versions

ATA586876A (de

Original Assignee

Beecham Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-08-09

Filing date

1976-08-06

Publication date

1979-01-10

1976-08-06 Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd

1979-01-10 Application granted granted Critical

1979-01-10 Publication of AT354448B publication Critical patent/AT354448B/de

1979-06-15 Publication of ATA586876A publication Critical patent/ATA586876A/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT586876A 1975-08-09 1976-08-06 Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen AT354448B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB33283/75A GB1504424A (en)	1975-08-09	1975-08-09	Isoquinoline-derived aminoethers

Publications (2)

Publication Number	Publication Date
AT354448B true AT354448B (de)	1979-01-10
ATA586876A ATA586876A (de)	1979-06-15

Family

ID=10350917

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT586876A AT354448B (de)	1975-08-09	1976-08-06	Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen
AT717378A AT353793B (de)	1975-08-09	1978-10-05	Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT717378A AT353793B (de)	1975-08-09	1978-10-05	Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen

Country Status (19)

Country	Link
US (1)	US4113869A (de)
JP (1)	JPS5223083A (de)
AT (2)	AT354448B (de)
AU (1)	AU498422B2 (de)
BE (1)	BE844783A (de)
CA (1)	CA1076119A (de)
CH (2)	CH622780A5 (de)
DE (1)	DE2635276A1 (de)
DK (1)	DK357976A (de)
ES (6)	ES450550A1 (de)
FR (1)	FR2320755A1 (de)
GB (1)	GB1504424A (de)
HU (1)	HU173560B (de)
IE (1)	IE43506B1 (de)
IL (1)	IL50176A (de)
NL (1)	NL7608856A (de)
NZ (1)	NZ181619A (de)
SE (1)	SE7608641L (de)
ZA (1)	ZA764555B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2711655A1 (de) *	1977-03-17	1978-09-21	Basf Ag	Pyridinyl-aminoalkylaether
US4340600A (en)	1980-05-22	1982-07-20	Smithkline Corporation	Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
US4766131A (en) *	1980-10-17	1988-08-23	Pennwalt Corporation	2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
US4375471A (en) *	1981-02-19	1983-03-01	Hoechst-Roussel Pharmaceuticals Inc.	4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US4551474A (en) *	1981-02-19	1985-11-05	Hoechst-Roussel Pharmaceuticals Incorporated	Methods of alleviating convulsions and pain employing 4-aryloxy-1,2,3,4 tetrahydroisoquinolines
US4477670A (en) *	1981-02-19	1984-10-16	Hoechst-Roussel Pharmaceuticals Inc.	4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US6562837B1 (en) *	1998-10-21	2003-05-13	Korea Institute Of Science & Technology	Use of tetrahydroisoquinoline compounds for the treatment of septicemia
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
AU781179B2 (en) *	1999-11-03	2005-05-12	Albany Molecular Research, Inc.	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
RU2293728C2 (ru) *	1999-11-03	2007-02-20	Эймр Текнолоджи, Инк.	Производные тетрагидроизохинолина, содержащая их фармацевтическая композиция, способ ингибирования синаптического захвата допамина и способ лечения
EP1113007A1 (de)	1999-12-24	2001-07-04	Pfizer Inc.	Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten
MXPA03000275A (es)	2000-07-11	2004-12-13	Albany Molecular Res Inc	Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
US7314937B2 (en) *	2002-03-21	2008-01-01	Eli Lilly And Company	Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
MX2007000428A (es)	2004-07-15	2008-03-05	Amr Technology Inc	Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina.
US20060111393A1 (en) *	2004-11-22	2006-05-25	Molino Bruce F	4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20060111394A1 (en) *	2004-11-22	2006-05-25	Molino Bruce F	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20060111385A1 (en) *	2004-11-22	2006-05-25	Molino Bruce F	Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
CN101128432A (zh) *	2004-12-17	2008-02-20	詹森药业有限公司	用于治疗中枢神经系统疾病的四氢异喹啉化合物
WO2006138604A1 (en) *	2005-06-17	2006-12-28	Janssen Pharmaceutica N.V.	Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders
JP2008543880A (ja)	2005-06-17	2008-12-04	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ナフチリジン化合物
UA95454C2 (uk) *	2005-07-15	2011-08-10	Амр Текнолоджи, Інк.	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
WO2008144305A1 (en) *	2007-05-18	2008-11-27	Janssen Pharmaceutica N.V.	Diaryl-substituted tetrahydroisoquinolines as histamine h3 receptor and serotonin transporter modulators
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) *	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9394333B2 (en)	2008-12-02	2016-07-19	Wave Life Sciences Japan	Method for the synthesis of phosphorus atom modified nucleic acids
KR20120023072A (ko) *	2009-05-12	2012-03-12	브리스톨-마이어스 스큅 컴퍼니	（Ｓ）-7-（〔1,2,4〕트리아졸〔1,5-ａ〕피리딘-6-일）-4-（3,4-디클로로페닐）-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
MX2011011901A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
MX2011011907A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma.
WO2011005761A1 (en)	2009-07-06	2011-01-13	Ontorii, Inc	Novel nucleic acid prodrugs and methods use thereof
EP2620428B1 (de) *	2010-09-24	2019-05-22	Wave Life Sciences Ltd.	Asymmetrische hilfsgruppe
CN107365339A (zh)	2011-07-19	2017-11-21	波涛生命科学有限公司	合成官能化核酸的方法
CN112007045A (zh)	2012-07-13	2020-12-01	波涛生命科学有限公司	手性控制
EP2872485B1 (de)	2012-07-13	2020-12-16	Wave Life Sciences Ltd.	Asymmetrische hilfsgruppe
KR101835401B1 (ko)	2012-07-13	2018-03-08	신 니뽄 바이오메디칼 라보라토리즈, 엘티디.	키랄 핵산 어쥬번트
JPWO2015108047A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
EP3095459A4 (de)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Chirales nukleinsäureadjuvans mit antitumorwirkung und antitumormittel
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
BR112016016400A2 (pt)	2014-01-16	2017-10-03	Wave Life Sciences Ltd	Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1058822A (en) *	1963-07-30	1967-02-15	Ici Ltd	3-amino-2-hydroxypropoxy heterocyclic derivatives
US3479358A (en) *	1966-09-19	1969-11-18	Warner Lambert Pharmaceutical	Hexahydro-9,4a - iminoethano-4a-h-xanthenes and process for their production
US3666763A (en) *	1970-01-06	1972-05-30	Hoffmann La Roche	4-phenyl isoquinolines and process for preparing same
US3947456A (en) *	1970-01-06	1976-03-30	Hoffman-La Roche Inc.	Substituted 4-phenyl isoquinolines
US3878215A (en) *	1971-12-01	1975-04-15	Sandoz Ag	2-Alkyl-3-substituted-4-aryl isoquinolines
US3910924A (en) *	1972-04-13	1975-10-07	Otsuka Pharma Co Ltd	3,4-Dihydrocarbostyril derivatives and a process for preparing the same
US3855227A (en) *	1972-05-08	1974-12-17	C Hollander	({31 )-di-o-isopropylidene-2-keto-l-gulonates
JPS5239035B2 (de) *	1972-12-14	1977-10-03
US3872125A (en) *	1973-03-03	1975-03-18	Sandoz Ag	3-substituted-4-aryl isoquinolines
US3870722A (en) *	1973-11-02	1975-03-11	Sandoz Ag	2-Methyl-3-substituted-4-aryl isoquinolines
AR206061A1 (es) *	1974-11-15	1976-06-23	Knoll Ag	Procedimiento para la produccion de nuevas 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7-, 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-isoquinolinas de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-6-metoxi-isoquinolinas y de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-7-metoxi-isoquinolinas eventualmente metiladas en la posicion 1

1975
- 1975-08-09 GB GB33283/75A patent/GB1504424A/en not_active Expired
1976
- 1976-07-28 IE IE1668/76A patent/IE43506B1/en unknown
- 1976-07-29 ZA ZA764555A patent/ZA764555B/xx unknown
- 1976-07-29 NZ NZ181619A patent/NZ181619A/xx unknown
- 1976-07-30 IL IL50176A patent/IL50176A/xx unknown
- 1976-07-30 BE BE169475A patent/BE844783A/xx unknown
- 1976-07-30 SE SE7608641A patent/SE7608641L/xx not_active Application Discontinuation
- 1976-08-02 US US05/710,446 patent/US4113869A/en not_active Expired - Lifetime
- 1976-08-05 DE DE19762635276 patent/DE2635276A1/de not_active Withdrawn
- 1976-08-05 CH CH1002076A patent/CH622780A5/de not_active IP Right Cessation
- 1976-08-06 AT AT586876A patent/AT354448B/de not_active IP Right Cessation
- 1976-08-06 ES ES450550A patent/ES450550A1/es not_active Expired
- 1976-08-06 CA CA258,633A patent/CA1076119A/en not_active Expired
- 1976-08-06 DK DK357976A patent/DK357976A/da not_active Application Discontinuation
- 1976-08-09 HU HU76BE1265A patent/HU173560B/hu unknown
- 1976-08-09 JP JP51094721A patent/JPS5223083A/ja active Pending
- 1976-08-09 NL NL7608856A patent/NL7608856A/xx not_active Application Discontinuation
- 1976-08-09 AU AU16702/76A patent/AU498422B2/en not_active Expired
- 1976-08-09 FR FR7624258A patent/FR2320755A1/fr active Granted
1977
- 1977-09-01 ES ES77462062A patent/ES462062A1/es not_active Expired
- 1977-09-01 ES ES462058A patent/ES462058A1/es not_active Expired
- 1977-09-01 ES ES462059A patent/ES462059A1/es not_active Expired
- 1977-09-01 ES ES462061A patent/ES462061A1/es not_active Expired
- 1977-09-01 ES ES462060A patent/ES462060A1/es not_active Expired
1978
- 1978-10-05 AT AT717378A patent/AT353793B/de not_active IP Right Cessation
1981
- 1981-01-27 CH CH52281A patent/CH626611A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES450550A1 (es)	1977-12-16
FR2320755A1 (fr)	1977-03-11
NZ181619A (en)	1979-08-31
ES462059A1 (es)	1978-06-16
ATA717378A (de)	1979-05-15
ES462061A1 (es)	1978-06-16
ES462060A1 (es)	1978-06-16
NL7608856A (nl)	1977-02-11
ES462062A1 (es)	1978-06-16
FR2320755B1 (de)	1979-09-14
IL50176A (en)	1979-10-31
DK357976A (da)	1977-02-10
ES462058A1 (es)	1978-06-16
GB1504424A (en)	1978-03-22
IE43506B1 (en)	1981-03-11
JPS5223083A (en)	1977-02-21
DE2635276A1 (de)	1977-02-17
IL50176A0 (en)	1976-09-30
AT353793B (de)	1979-12-10
AU498422B2 (en)	1979-03-15
SE7608641L (sv)	1977-02-10
BE844783A (fr)	1977-01-31
AU1670276A (en)	1978-02-16
HU173560B (hu)	1979-06-28
ATA586876A (de)	1979-06-15
CH622780A5 (de)	1981-04-30
CA1076119A (en)	1980-04-22
CH626611A5 (de)	1981-11-30
US4113869A (en)	1978-09-12
IE43506L (en)	1977-02-09
ZA764555B (en)	1977-07-27

Publication	Publication Date	Title
AT353793B (de)	1979-12-10	Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen
AT358035B (de)	1980-08-11	Verfahren zur herstellung von neuen indolizin- derivaten und von ihren saeureadditionssalzen
AT360533B (de)	1981-01-12	Verfahren zur herstellung von neuen trans- -hexahydropyrido-indolen und ihren saeure- additionssalzen
ATA487977A (de)	1979-11-15	Verfahren zur herstellung von neuen thieno- pyridinderivaten und ihren salzen
ATA612476A (de)	1980-04-15	Verfahren zur herstellung von neuen phenoxyal- kylcarbonsaeurederivaten und ihren salzen
AT346341B (de)	1978-11-10	Verfahren zur herstellung von neuen butyrophenonderivaten und ihren salzen
ATA702976A (de)	1981-02-15	Verfahren zur herstellung von neuen n-aryl-n- (4-piperidinyl)-arylacetamiden und ihren salzen
AT349017B (de)	1979-03-12	Verfahren zur herstellung von neuen 1-subst.-4 -aroyl-4-hydroxypiperidinen und ihren salzen
AT349004B (de)	1979-03-12	Verfahren zur herstellung von neuen 4- hydroxyindol-derivaten und ihren salzen
AT359060B (de)	1980-10-27	Verfahren zur herstellung von neuen benz-acyl- benzimidazol-2-derivaten und ihren salzen
AT356110B (de)	1980-04-10	Verfahren zur herstellung von neuen benzyliso- chinolinderivaten und ihren saeureadditions- salzen
ATA602576A (de)	1980-12-15	Verfahren zur herstellung von neuen tert- -butylaminopropoxy-indolen und ihren saeure- additionssalzen
AT342034B (de)	1978-03-10	Verfahren zur herstellung von neuen 4,4-diphenyl-2-hydroxybutylaminen und ihren salzen
AT358030B (de)	1980-08-11	Verfahren zur herstellung von neuen thiazolidinderivaten und ihren salzen
AT339898B (de)	1977-11-10	Verfahren zur herstellung von neuen, in 2-stellung substituierten 4,5-diphenylthiazolderivaten und von ihren salzen
AT354427B (de)	1979-01-10	Verfahren zur herstellung von neuen alkin- derivaten und ihren metallsalzen
AT348532B (de)	1979-02-26	Verfahren zur herstellung von neuen tricyclischen dibenzazepinderivaten und ihren salzen
AT358027B (de)	1980-08-11	Verfahren zur herstellung von neuen indol- derivaten und ihren salzen
AT358046B (de)	1980-08-11	Verfahren zur herstellung von neuen trans-5a- -aryl-decahydrobenzazepinen und ihren saeure- additionssalzen
AT357535B (de)	1980-07-10	Verfahren zur herstellung von neuen 4-amino- transdecahydrochinolinderivaten und ihren saeureadditionssalzen
AT355569B (de)	1980-03-10	Verfahren zur herstellung von neuen, substi- tuierten pyridoindolen und ihren salzen
AT349005B (de)	1979-03-12	Verfahren zur herstellung von neuen 3- nitropyrazol-derivaten und ihren salzen
AT356113B (de)	1980-04-10	Verfahren zur herstellung von neuen chinazolin- derivaten und ihren salzen
ATA668277A (de)	1980-06-15	Verfahren zur herstellung von neuen 4-hydroxy- indol-derivaten und ihren salzen
ATA363180A (de)	1982-11-15	Verfahren zur herstellung von neuen cyproheptadinderivaten und ihren salzen

Legal Events

Date	Code	Title	Description
1983-03-15	ELJ	Ceased due to non-payment of the annual fee