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AT352270B - METHOD FOR PRODUCING THE NEW CLAVULANIC ACIDS - Google Patents

METHOD FOR PRODUCING THE NEW CLAVULANIC ACIDS

Info

Publication number
AT352270B
AT352270B AT298575A AT298575A AT352270B AT 352270 B AT352270 B AT 352270B AT 298575 A AT298575 A AT 298575A AT 298575 A AT298575 A AT 298575A AT 352270 B AT352270 B AT 352270B
Authority
AT
Austria
Prior art keywords
producing
new
clavulanic acids
clavulanic
acids
Prior art date
Application number
AT298575A
Other languages
German (de)
Other versions
ATA298575A (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of ATA298575A publication Critical patent/ATA298575A/en
Application granted granted Critical
Publication of AT352270B publication Critical patent/AT352270B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT298575A 1974-04-20 1975-04-18 METHOD FOR PRODUCING THE NEW CLAVULANIC ACIDS AT352270B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus

Publications (2)

Publication Number Publication Date
ATA298575A ATA298575A (en) 1979-02-15
AT352270B true AT352270B (en) 1979-09-10

Family

ID=10094711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT298575A AT352270B (en) 1974-04-20 1975-04-18 METHOD FOR PRODUCING THE NEW CLAVULANIC ACIDS

Country Status (6)

Country Link
AT (1) AT352270B (en)
BE (1) BE827926A (en)
CS (1) CS231157B2 (en)
GB (1) GB1508977A (en)
SU (1) SU648117A3 (en)
ZA (1) ZA752492B (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098897A (en) 1975-04-14 1978-07-04 Beecham Group Limited Anti bacterial agents
IE44295B1 (en) * 1975-10-13 1981-10-07 Beecham Group Ltd Clavulanic acid derivatives
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
EP0008525A3 (en) * 1978-08-25 1980-05-28 Beecham Group Plc Pharmaceutical compositions and process for their preparation
IL58461A0 (en) * 1978-10-27 1980-01-31 Beecham Group Ltd Intramammary compositions comprising a clavulanic acid salt
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
AU600655B2 (en) * 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
NZ223316A (en) * 1987-01-29 1989-10-27 Beecham Group Plc Crystalline potassium clavulanate and pharmaceutical compositions
US5288861A (en) * 1987-01-29 1994-02-22 Beecham Group Plc Potassium clavulanate in rosette form
US5750685A (en) * 1987-01-29 1998-05-12 Smithkline Beecham, P.L.C. Process for preparing potassium clavulanate in rossette form
AT400033B (en) 1992-03-10 1995-09-25 Biochemie Gmbh NEW METHOD FOR ISOLATING AND PURIFYING CLAVULANIC ACID AND FOR PRODUCING PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF
AT399155B (en) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih NEW ALKYLENE DIAMMONIUM DICLAVULANATE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
SI9300296B (en) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Process and intermediates for the preparation of clavulanic acid
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (en) * 1992-10-21 1999-06-15 김충환 Process for preparing salts of clavulanic acid
DE4318916A1 (en) * 1993-06-07 1994-12-08 Bayer Ag Cyclobutylazole
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9408117D0 (en) 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
GB9424950D0 (en) * 1994-12-10 1995-02-08 Smithkline Beecham Plc Novel process
MD1744F2 (en) * 1995-02-25 2001-09-30 Spurcourt Limited Clavulanates and process for preparation thereof
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
KR100200242B1 (en) * 1995-05-16 1999-06-15 김충환 Process for preparing clavulanic acid salt
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ES2101658B1 (en) * 1995-11-23 1998-03-01 Antibioticos Sa NEW PROCEDURE FOR THE PRODUCTION OF CLAVULANIC ACID AND ITS SALTS.
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
GB9616536D0 (en) 1996-08-06 1996-09-25 Quadrant Holdings Cambridge Co-amoxiclav dosage form
AT404728B (en) * 1996-11-27 1999-02-25 Biochemie Gmbh METHOD FOR PRODUCING CLAVULIC ACID AMINE SALTS
US7250176B1 (en) 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US6489319B2 (en) 1999-08-16 2002-12-03 Revaax Pharmaceuticals, Llc Neurotherapeutic use of carboxypeptidase inhibitors
CA2383522C (en) 1999-08-16 2011-12-06 Revaax Pharmaceuticals, Llc Neurotherapeutic composition and method
US6426342B2 (en) 1999-08-16 2002-07-30 Revaax Pharmaceuticals, Llc Use of β-lactamase inhibitors as neuroprotectants
NZ522414A (en) 2000-05-13 2004-05-28 Smithkline Beecham P Process for the purification of a salt of clavulanic acid
EP1330236A2 (en) 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
ES2357595B1 (en) * 2009-10-02 2012-03-15 Instituto Mediterr�?Neo Para El Avance De La Biotecnolog�?A Y La Investigación Sanitaria (Fundación Imabis) COMPOSITION OF � CL CLAVULENT ACID AND USE FOR DIAGNOSIS IN ALLERGOLOGY A A.
TR200909787A2 (en) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Pharmaceutical formulations containing a third generation cephalosporin and clavulanic acid.
TR201000688A2 (en) 2010-01-29 2011-08-22 B�Lg�� Mahmut Effervescent formulations containing cefaclor and clavulanic acid as active ingredient.
TR201000686A1 (en) 2010-01-29 2011-08-22 B�Lg�� Mahmut Water-soluble cefdinir and clavulanic acid formulations for the treatment of bacterial infections.
TR201000687A1 (en) 2010-01-29 2011-08-22 Bi̇lgi̇ç Mahmut Effervescent formulations containing cefixime and clavulanic acid as active ingredient
EP2589663A1 (en) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Process for production of clavulanic acid
CN115433701B (en) * 2022-11-08 2023-03-17 南京农业大学 A strain of Proteus and its agent and its application in degrading cephalosporin antibiotics

Also Published As

Publication number Publication date
GB1508977A (en) 1978-04-26
ATA298575A (en) 1979-02-15
SU648117A3 (en) 1979-02-15
CS231157B2 (en) 1984-10-15
ZA752492B (en) 1976-06-30
CS272175A2 (en) 1984-02-13
BE827926A (en) 1975-10-14

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
ELA Expired due to lapse of time