AT348525B - Verfahren zur herstellung von neuen 1- (triarylalkyl)-4-phenylpiperidinderivaten und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen 1- (triarylalkyl)-4-phenylpiperidinderivaten und deren saeureadditionssalzen

Info

Publication number: AT348525B
Authority: AT; Austria
Prior art keywords: triarylalkyl; acid addition; addition salts; producing new; phenylpiperidine derivatives
Prior art date: 1975-04-16

Application number

AT279076A

Other languages

English (en)

Other versions

ATA279076A (de

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-16

Filing date

1976-04-15

Publication date

1979-02-26

1976-04-15 Application filed by Searle & Co filed Critical Searle & Co

1978-07-15 Publication of ATA279076A publication Critical patent/ATA279076A/de

1979-02-26 Application granted granted Critical

1979-02-26 Publication of AT348525B publication Critical patent/AT348525B/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/64—Acyl halides
- C07C57/72—Acyl halides containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AT279076A 1975-04-16 1976-04-15 Verfahren zur herstellung von neuen 1- (triarylalkyl)-4-phenylpiperidinderivaten und deren saeureadditionssalzen AT348525B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/568,439 US3998832A (en)	1975-04-16	1975-04-16	Anti-diarrheal compounds

Publications (2)

Publication Number	Publication Date
ATA279076A ATA279076A (de)	1978-07-15
AT348525B true AT348525B (de)	1979-02-26

Family

ID=24271294

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT278976A AT347463B (de)	1975-04-16	1976-04-15	Verfahren zur herstellung von neuen 1,1,1- triarylalkylaminen und deren saeureadditions- salzen
AT279076A AT348525B (de)	1975-04-16	1976-04-15	Verfahren zur herstellung von neuen 1- (triarylalkyl)-4-phenylpiperidinderivaten und deren saeureadditionssalzen
AT32178A AT347952B (de)	1975-04-16	1978-01-17	Verfahren zur herstellung von neuen 1,1,1- triarylalkylaminen und deren salzen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT278976A AT347463B (de)	1975-04-16	1976-04-15	Verfahren zur herstellung von neuen 1,1,1- triarylalkylaminen und deren saeureadditions- salzen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT32178A AT347952B (de)	1975-04-16	1978-01-17	Verfahren zur herstellung von neuen 1,1,1- triarylalkylaminen und deren salzen

Country Status (27)

Country	Link
US (1)	US3998832A (de)
JP (2)	JPS51127054A (de)
AR (3)	AR211859A1 (de)
AT (3)	AT347463B (de)
AU (2)	AU502260B2 (de)
BE (2)	BE840797A (de)
CA (2)	CA1079734A (de)
CH (5)	CH614197A5 (de)
DE (2)	DE2616616A1 (de)
DK (2)	DK174776A (de)
EG (1)	EG12409A (de)
ES (3)	ES447011A1 (de)
FI (2)	FI761042A (de)
FR (2)	FR2307535A1 (de)
GB (2)	GB1537880A (de)
GR (2)	GR58247B (de)
HU (1)	HU173012B (de)
IE (2)	IE42977B1 (de)
IL (2)	IL49422A (de)
NL (2)	NL7603641A (de)
NO (2)	NO761303L (de)
NZ (1)	NZ180612A (de)
OA (1)	OA05304A (de)
PH (1)	PH11412A (de)
PT (2)	PT65017B (de)
SE (2)	SE7604476L (de)
ZA (2)	ZA761681B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4086227A (en) *	1975-04-16	1978-04-25	G. D. Searle & Co.	Novel anti-diarrheal 4-azatricyclo[4.3.1.13,8 ] undecane derivatives
DK462377A (da) *	1976-10-18	1978-04-19	Searle & Co	1-(3,3,3-triarylpropyl)-4-phenyl-4-piperidinomethanolethere
US4069223A (en) *	1977-05-02	1978-01-17	G. D. Searle & Co.	4-Aminomethyl-1-(3,3,3-triarylpropyl)-4-arylpiperidine and derivatives thereof
US4116963A (en) *	1977-05-23	1978-09-26	G.D. Searle & Co.	3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy piperidines and related compounds
US4194045A (en) *	1977-12-27	1980-03-18	G. D. Searle & Co.	1-(3,3-Diaryl-3-oxadiazolalkyl)-4-phenyl-4-piperidinomethanols and related compounds
US4203990A (en) *	1979-04-30	1980-05-20	G. D. Searle & Co.	Anti-diarrheal 2-substituted quinuclidines
US4203989A (en) *	1979-04-30	1980-05-20	G. D. Searle & Co.	Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4485109A (en) *	1982-05-07	1984-11-27	E. I. Du Pont De Nemours And Company	4-Aryl-4-piperidinecarbinols
US5962477A (en) *	1994-04-12	1999-10-05	Adolor Corporation	Screening methods for cytokine inhibitors
US6190691B1 (en)	1994-04-12	2001-02-20	Adolor Corporation	Methods for treating inflammatory conditions
US6573282B1 (en)	1995-09-12	2003-06-03	Adolor Corporation	Peripherally active anti-hyperalgesic opiates
US5849761A (en) *	1995-09-12	1998-12-15	Regents Of The University Of California	Peripherally active anti-hyperalgesic opiates
US5889038A (en) *	1996-03-20	1999-03-30	Children's Hospital	Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
CA2881935A1 (en) *	2012-08-15	2014-02-20	Glaxo Group Limited	Process for preparing a 1-(2-haolethyl)-4-piperidine carboxylate intermediate useful in the synthesis of umeclidinium bromide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2604473A (en) *	1950-07-17	1952-07-22	Schering Corp	Propylamine type antihistamines
GB1125112A (en) *	1966-01-07	1968-08-28	Science Union & Cie	New derivatives of diazabicyclo-decane and process for preparing them
US3917615A (en) *	1974-04-01	1975-11-04	Searle & Co	1,1-Diaryl-1-oxadiazol-alkylamines

1975
- 1975-04-16 US US05/568,439 patent/US3998832A/en not_active Expired - Lifetime
1976
- 1976-03-18 ZA ZA761681A patent/ZA761681B/xx unknown
- 1976-04-07 NL NL7603641A patent/NL7603641A/xx not_active Application Discontinuation
- 1976-04-12 EG EG76212A patent/EG12409A/xx active
- 1976-04-14 AR AR262892A patent/AR211859A1/es active
- 1976-04-14 AR AR262893A patent/AR216438A1/es active
- 1976-04-14 NO NO761303A patent/NO761303L/no unknown
- 1976-04-14 DK DK174776A patent/DK174776A/da unknown
- 1976-04-14 DK DK173976A patent/DK173976A/da active IP Right Grant
- 1976-04-14 IL IL49422A patent/IL49422A/xx unknown
- 1976-04-14 ES ES447011A patent/ES447011A1/es not_active Expired
- 1976-04-14 ES ES447010A patent/ES447010A1/es not_active Expired
- 1976-04-14 IL IL49424A patent/IL49424A/xx unknown
- 1976-04-14 NO NO761304A patent/NO761304L/no unknown
- 1976-04-15 CH CH485276A patent/CH614197A5/xx not_active IP Right Cessation
- 1976-04-15 CH CH175379A patent/CH614448A5/xx not_active IP Right Cessation
- 1976-04-15 FR FR7611236A patent/FR2307535A1/fr active Granted
- 1976-04-15 GB GB15542/76A patent/GB1537880A/en not_active Expired
- 1976-04-15 AT AT278976A patent/AT347463B/de not_active IP Right Cessation
- 1976-04-15 ZA ZA762292A patent/ZA762292B/xx unknown
- 1976-04-15 CH CH485376A patent/CH626879A5/de not_active IP Right Cessation
- 1976-04-15 NZ NZ180612A patent/NZ180612A/xx unknown
- 1976-04-15 FI FI761042A patent/FI761042A/fi not_active Application Discontinuation
- 1976-04-15 FI FI761041A patent/FI761041A/fi not_active Application Discontinuation
- 1976-04-15 CA CA250,373A patent/CA1079734A/en not_active Expired
- 1976-04-15 FR FR7611237A patent/FR2307530A1/fr active Granted
- 1976-04-15 JP JP51043021A patent/JPS51127054A/ja active Pending
- 1976-04-15 BE BE166202A patent/BE840797A/xx unknown
- 1976-04-15 HU HU76SE00001827A patent/HU173012B/hu unknown
- 1976-04-15 DE DE19762616616 patent/DE2616616A1/de not_active Withdrawn
- 1976-04-15 NL NL7604063A patent/NL7604063A/xx not_active Application Discontinuation
- 1976-04-15 GB GB15541/76A patent/GB1540103A/en not_active Expired
- 1976-04-15 PT PT65017A patent/PT65017B/pt unknown
- 1976-04-15 IE IE815/76A patent/IE42977B1/en unknown
- 1976-04-15 CA CA250,355A patent/CA1072089A/en not_active Expired
- 1976-04-15 SE SE7604476A patent/SE7604476L/xx not_active Application Discontinuation
- 1976-04-15 IE IE816/76A patent/IE42978B1/en unknown
- 1976-04-15 DE DE19762616619 patent/DE2616619A1/de not_active Withdrawn
- 1976-04-15 SE SE7604475A patent/SE7604475L/xx unknown
- 1976-04-15 AU AU13042/76A patent/AU502260B2/en not_active Expired
- 1976-04-15 GR GR50558A patent/GR58247B/el unknown
- 1976-04-15 AT AT279076A patent/AT348525B/de not_active IP Right Cessation
- 1976-04-15 GR GR50559A patent/GR58248B/el unknown
- 1976-04-15 PT PT65016A patent/PT65016B/pt unknown
- 1976-04-15 OA OA55799A patent/OA05304A/xx unknown
- 1976-04-15 JP JP51043020A patent/JPS51131880A/ja active Pending
- 1976-04-15 BE BE166203A patent/BE840798A/xx unknown
- 1976-04-15 AU AU13043/76A patent/AU499878B2/en not_active Expired
- 1976-04-19 PH PH18337A patent/PH11412A/en unknown
- 1976-11-29 AR AR265651A patent/AR208862A1/es active
1977
- 1977-05-30 ES ES459283A patent/ES459283A1/es not_active Expired
1978
- 1978-01-17 AT AT32178A patent/AT347952B/de not_active IP Right Cessation
1981
- 1981-02-12 CH CH94781A patent/CH629190A5/de not_active IP Right Cessation
- 1981-02-12 CH CH94881A patent/CH629191A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CH614197A5 (en)	1979-11-15
ATA278976A (de)	1978-05-15
GR58248B (en)	1977-08-31
IE42977L (en)	1976-10-16
FR2307535A1 (fr)	1976-11-12
GB1537880A (en)	1979-01-04
GB1540103A (en)	1979-02-07
SE7604476L (sv)	1976-10-17
ES459283A1 (es)	1978-03-01
DE2616619A1 (de)	1976-10-28
ATA32178A (de)	1978-06-15
IL49424A0 (en)	1976-06-30
EG12409A (en)	1978-12-31
AT347952B (de)	1979-01-25
PT65016A (en)	1976-05-01
CH629190A5 (en)	1982-04-15
GR58247B (en)	1977-08-31
FR2307530A1 (fr)	1976-11-12
SE7604475L (sv)	1976-10-17
ZA761681B (en)	1977-04-27
PT65017B (en)	1977-09-09
DK173976A (da)	1976-10-17
FR2307530B1 (de)	1978-11-17
IL49422A (en)	1979-09-30
NL7604063A (nl)	1976-10-19
AR216438A1 (es)	1979-12-28
CH629191A5 (en)	1982-04-15
OA05304A (fr)	1981-02-28
HU173012B (hu)	1979-01-28
DE2616616A1 (de)	1976-10-28
IL49422A0 (en)	1976-06-30
CA1079734A (en)	1980-06-17
AU1304276A (en)	1977-10-20
AU502260B2 (en)	1979-07-19
DK174776A (da)	1976-10-17
ES447010A1 (es)	1977-10-01
AR211859A1 (es)	1978-03-31
BE840797A (fr)	1976-10-15
JPS51131880A (en)	1976-11-16
ATA279076A (de)	1978-07-15
FI761042A (de)	1976-10-17
ZA762292B (en)	1977-05-25
PT65016B (en)	1977-09-09
PT65017A (en)	1976-05-01
NO761304L (de)	1976-10-19
JPS51127054A (en)	1976-11-05
ES447011A1 (es)	1977-11-16
NZ180612A (en)	1978-04-28
IE42978L (en)	1976-10-16
AT347463B (de)	1978-12-27
FR2307535B1 (de)	1978-11-17
CH614448A5 (en)	1979-11-30
CA1072089A (en)	1980-02-19
AR208862A1 (es)	1977-02-28
CH626879A5 (en)	1981-12-15
BE840798A (fr)	1976-10-15
IE42978B1 (en)	1980-11-19
NL7603641A (nl)	1976-10-19
AU499878B2 (en)	1979-05-03
IL49424A (en)	1979-01-31
AU1304376A (en)	1977-10-20
NO761303L (de)	1976-10-19
IE42977B1 (en)	1980-11-19
PH11412A (en)	1977-12-12
US3998832A (en)	1976-12-21
FI761041A (de)	1976-10-17

Publication	Publication Date	Title
AT344683B (de)	1978-08-10	Verfahren zur herstellung von neuen substituierten 3-phenoxy-2-hydroxy-1-aminopropanen und deren saeureadditionssalzen
AT352726B (de)	1979-10-10	Verfahren zur herstellung von neuen piperidin- derivaten und deren salzen
AT340895B (de)	1978-01-10	Verfahren zur herstellung von neuen p-trifluormethylacylophenon-o- (2-aminoathyl) -oximathern und deren saureadditionssalzen
AT363457B (de)	1981-08-10	Verfahren zur herstellung von neuen substituierten 1-(3-aminosulfonylphenyl)-2-alkylaminoaethanolen und deren saeureadditionssalzen
AT355563B (de)	1980-03-10	Verfahren zur herstellung von neuen imidazolyl- oximaethern und von deren saeureadditionssalzen
AT355017B (de)	1980-02-11	Verfahren zur herstellung von neuen benziso- thiazolonen und deren saeureadditionssalzen
AT348525B (de)	1979-02-26	Verfahren zur herstellung von neuen 1- (triarylalkyl)-4-phenylpiperidinderivaten und deren saeureadditionssalzen
AT355570B (de)	1980-03-10	Verfahren zur herstellung von neuen piperidin- derivaten und deren salzen
AT357159B (de)	1980-06-25	Verfahren zur herstellung von neuen piperidin- derivaten und deren salzen
AT366666B (de)	1982-04-26	Verfahren zur herstellung von neuen amidinosulfon- saeurederivaten und von deren salzen
AT350552B (de)	1979-06-11	Verfahren zur herstellung von neuen propargyl- 2-phenylamino-imidazolinen-(2) und deren saeureadditionssalzen
AT353970B (de)	1979-12-10	Verfahren zur herstellung von neuen 7-methoxy- cephalosporinen und deren salzen
AT351537B (de)	1979-07-25	Verfahren zur herstellung von neuen piperidin- derivaten und deren salzen
AT346303B (de)	1978-11-10	Verfahren zur herstellung von neuen 7- aminobenzocycloheptenen und deren saeure- additionssalzen
AT340896B (de)	1978-01-10	Verfahren zur herstellung von neuen p-halogen-acylophenon- o - (2-aminoathyl)-oximathern und deren saureadditionssalzen
AT356106B (de)	1980-04-10	Verfahren zur herstellung von neuen piperidin- derivaten und deren salzen
AT352724B (de)	1979-10-10	Verfahren zur herstellung von neuen substi- tuierten sulfoximiden und deren salzen
AT340897B (de)	1978-01-10	Verfahren zur herstellung von neuen p-methylthioacylophenon-o- (2-aminoathyl)-oximathern und deren saureadditionssalzen
AT351045B (de)	1979-07-10	Verfahren zur herstellung von neuen guanidin- derivaten und von deren saeureadditonssalzen
AT342021B (de)	1978-03-10	Verfahren zur herstellung von neuen p-methylsulfinyl-acylophenon-o- (2-aminoathyl)-oximathern und deren saureadditionssalzen
AT340894B (de)	1978-01-10	Verfahren zur herstellung von neuen p-nitro-acylophenon-o- (2-aminoathyl) -oximather und deren saureadditionssalzen
AT352727B (de)	1979-10-10	Verfahren zur herstellung von neuen indol- derivaten und deren salzen
AT348979B (de)	1979-03-12	Verfahren zur herstellung von neuen 7-aminomethylbenzocycloheptenen und deren saeureadditonssalzen
ATA712478A (de)	1980-05-15	Verfahren zur herstellung von neuen piperidin- derivaten und deren salzen
ATA712578A (de)	1980-05-15	Verfahren zur herstellung von neuen piperidin- derivaten und deren salzen

Legal Events

Date	Code	Title	Description
1980-03-15	ELJ	Ceased due to non-payment of the annual fee
1983-04-15	ELJ	Ceased due to non-payment of the annual fee