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AT292681B - PROCESS FOR THE PREPARATION OF NEW 1-PHENOXY-2-HYDROXY-3-ALKYLAMINOPROPANES AND THEIR ACID-ADDITION SALTS - Google Patents

PROCESS FOR THE PREPARATION OF NEW 1-PHENOXY-2-HYDROXY-3-ALKYLAMINOPROPANES AND THEIR ACID-ADDITION SALTS

Info

Publication number
AT292681B
AT292681B AT08803/70A AT880370A AT292681B AT 292681 B AT292681 B AT 292681B AT 08803/70 A AT08803/70 A AT 08803/70A AT 880370 A AT880370 A AT 880370A AT 292681 B AT292681 B AT 292681B
Authority
AT
Austria
Prior art keywords
alkylaminopropanes
phenoxy
hydroxy
preparation
acid
Prior art date
Application number
AT08803/70A
Other languages
German (de)
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Application granted granted Critical
Publication of AT292681B publication Critical patent/AT292681B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08803/70A 1967-12-13 1970-12-13 PROCESS FOR THE PREPARATION OF NEW 1-PHENOXY-2-HYDROXY-3-ALKYLAMINOPROPANES AND THEIR ACID-ADDITION SALTS AT292681B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1643262A DE1643262C3 (en) 1967-12-13 1967-12-13 i-Phenoxy ^ -hydroxy-S-alklyaminopropane, process for their preparation and medicaments containing these compounds

Publications (1)

Publication Number Publication Date
AT292681B true AT292681B (en) 1971-08-15

Family

ID=5684274

Family Applications (13)

Application Number Title Priority Date Filing Date
AT879370A AT292673B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT880170A AT292679B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT1216668A AT292670B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879570A AT292674B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879670A AT292675B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879470A AT294799B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT595771A AT298463B (en) 1967-12-13 1968-12-13 Process for the preparation of new racemic or optically active 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879770A AT292676B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879970A AT298459B (en) 1967-12-13 1968-12-13 Process for the preparation of new racemic or optically active 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879870A AT292677B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT880270A AT292680B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT880070A AT292678B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT08803/70A AT292681B (en) 1967-12-13 1970-12-13 PROCESS FOR THE PREPARATION OF NEW 1-PHENOXY-2-HYDROXY-3-ALKYLAMINOPROPANES AND THEIR ACID-ADDITION SALTS

Family Applications Before (12)

Application Number Title Priority Date Filing Date
AT879370A AT292673B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT880170A AT292679B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT1216668A AT292670B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879570A AT292674B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879670A AT292675B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879470A AT294799B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT595771A AT298463B (en) 1967-12-13 1968-12-13 Process for the preparation of new racemic or optically active 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879770A AT292676B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879970A AT298459B (en) 1967-12-13 1968-12-13 Process for the preparation of new racemic or optically active 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT879870A AT292677B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT880270A AT292680B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts
AT880070A AT292678B (en) 1967-12-13 1968-12-13 Process for the preparation of new 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts

Country Status (21)

Country Link
US (1) US3872147A (en)
JP (1) JPS5220457B1 (en)
AT (13) AT292673B (en)
BE (1) BE725490A (en)
BG (9) BG17298A3 (en)
BR (1) BR6804840D0 (en)
CA (1) CA954528A (en)
CH (2) CH532015A (en)
DE (1) DE1643262C3 (en)
DK (1) DK131029B (en)
ES (11) ES361189A1 (en)
FI (1) FI49497C (en)
FR (2) FR1596100A (en)
GB (1) GB1260866A (en)
HU (1) HU162734B (en)
IE (1) IE32758B1 (en)
IL (1) IL31266A (en)
NL (3) NL146709B (en)
PH (1) PH9266A (en)
SE (1) SE367396B (en)
YU (12) YU33949B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541130A (en) * 1967-02-06 1970-11-17 Boehringer Sohn Ingelheim 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
US4086272A (en) * 1970-07-18 1978-04-25 Pfizer Inc. Phenyl-alkanolamine, alkylamine and alpha-aminoalkyl ketone derivatives as heart stimulants
US3998874A (en) * 1971-03-23 1976-12-21 Gist-Brocades N.V. Phenylene di-ethers
US4038414A (en) * 1972-06-08 1977-07-26 Ciba-Geigy Corporation Amines and processes for their manufacture
US4084002A (en) * 1973-02-28 1978-04-11 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing a 1-phenoxy-2-hydroxy-3-alkynylamino-propane and method of use
DE2309887C2 (en) * 1973-02-28 1983-11-10 C.H. Boehringer Sohn, 6507 Ingelheim 1-aryloxy-2-hydroxy-3-alkynylaminopropane derivatives and their physiologically acceptable acid addition salts, pharmaceutical preparations and manufacturing processes for the compounds
US4161530A (en) * 1975-01-06 1979-07-17 Ciba-Geigy Corporation Pharmaceutical combination preparations as hypnotics
US4094991A (en) * 1975-06-17 1978-06-13 Nippon Shinyaku Co., Ltd. Substituted n-(carboxymethyl)-3-aminopropan-2-ol derivatives
US4243681A (en) * 1977-10-11 1981-01-06 Mead Johnson & Company Alkylthiophenoxypropanolamines and pharmaceutical compositions and uses thereof
DE2839475A1 (en) * 1978-09-11 1980-03-20 Dolorgiet Arzneimittelfabrik ISOPROPYLAMINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
DE3062216D1 (en) * 1979-09-06 1983-04-07 Beecham Group Plc Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them
JPS56142262A (en) 1980-04-08 1981-11-06 Nippon Shinyaku Co Ltd Piperazine derivative
US4593119A (en) * 1980-11-28 1986-06-03 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4396629A (en) * 1980-12-29 1983-08-02 Sterling Drug Inc. Compositions, processes and method
DE3131527A1 (en) * 1981-08-08 1983-02-24 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-PHENYL-2-AMINOCARBONYLINDOL COMPOUNDS AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
JPH0720861B2 (en) * 1984-04-09 1995-03-08 ザ デュポン マーク ファーマソウテイカル カンパニー Pharmaceutical compositions and methods for the treatment or prevention of heart disorders
US4652584A (en) * 1984-07-13 1987-03-24 Mcneilab, Inc. Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
DE3665168D1 (en) * 1985-12-24 1989-09-28 Merck & Co Inc Oculoselective beta blockers
US5480908A (en) * 1993-12-13 1996-01-02 American Cyanamid Company β3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes

Also Published As

Publication number Publication date
CH556816A (en) 1974-12-13
FI49497B (en) 1975-04-01
ES375448A1 (en) 1972-05-01
YU238474A (en) 1978-02-28
YU33948B (en) 1978-09-08
BR6804840D0 (en) 1973-03-08
YU294968A (en) 1978-02-28
BG16331A3 (en) 1972-08-20
IL31266A (en) 1974-09-10
FR1596100A (en) 1970-06-15
IE32758L (en) 1969-06-13
IL31266A0 (en) 1969-02-27
ES375444A1 (en) 1972-05-01
AT292680B (en) 1971-09-10
YU33947B (en) 1978-09-08
YU33856B (en) 1978-06-30
ES375446A1 (en) 1972-05-01
BE725490A (en) 1969-06-13
YU33851B (en) 1978-06-30
ES361189A1 (en) 1970-08-16
FI49497C (en) 1975-07-10
YU238274A (en) 1977-12-31
DK131029B (en) 1975-05-20
YU238074A (en) 1977-12-31
AT292675B (en) 1971-09-10
AT292674B (en) 1971-09-10
NL7501792A (en) 1975-05-30
AT294799B (en) 1971-12-10
DE1643262B2 (en) 1974-11-07
BG16444A3 (en) 1972-11-20
CH532015A (en) 1972-12-31
ES375450A1 (en) 1972-05-01
BG19135A3 (en) 1975-04-30
BG16329A3 (en) 1972-08-20
YU237774A (en) 1978-02-28
SE367396B (en) 1974-05-27
YU237674A (en) 1977-10-31
BG16445A3 (en) 1972-11-20
NL146709B (en) 1975-08-15
YU33949B (en) 1978-09-08
YU237874A (en) 1977-12-31
YU33855B (en) 1978-06-30
IE32758B1 (en) 1973-11-28
ES375445A1 (en) 1972-05-16
AT298463B (en) 1972-05-10
AT292678B (en) 1971-09-10
AT292679B (en) 1971-09-10
YU237574A (en) 1978-02-28
BG16330A3 (en) 1972-08-20
AT292673B (en) 1971-09-10
YU238374A (en) 1977-12-31
BG17298A3 (en) 1973-07-25
YU237474A (en) 1977-12-31
ES375451A1 (en) 1972-05-01
YU33854B (en) 1978-06-30
AT298459B (en) 1972-05-10
BG16332A3 (en) 1972-08-20
BG17297A3 (en) 1973-07-25
DE1643262A1 (en) 1972-04-20
PH9266A (en) 1975-07-30
YU237974A (en) 1977-12-31
YU238174A (en) 1977-10-31
US3872147A (en) 1975-03-18
DE1643262C3 (en) 1975-06-26
DK131029C (en) 1975-10-06
ES375452A1 (en) 1972-05-16
FR8328M (en) 1970-12-07
NL6817768A (en) 1969-06-17
AT292676B (en) 1971-09-10
NL151354B (en) 1976-11-15
HU162734B (en) 1973-04-28
AT292677B (en) 1971-09-10
NL7501794A (en) 1975-05-30
YU33774B (en) 1978-05-15
CA954528A (en) 1974-09-10
GB1260866A (en) 1972-01-19
YU33852B (en) 1978-06-30
ES375447A1 (en) 1972-05-01
JPS5220457B1 (en) 1977-06-03
YU33773B (en) 1978-05-15
YU33946B (en) 1978-09-08
ES375449A1 (en) 1972-05-01
ES375453A1 (en) 1972-05-16
AT292670B (en) 1971-09-10
YU33853B (en) 1978-06-30

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