AT291247B - Verfahren zur Herstellung von neuen 1H-Imidazo[4,5-b]pyrazin-2-onen - Google Patents
Verfahren zur Herstellung von neuen 1H-Imidazo[4,5-b]pyrazin-2-onenInfo
- Publication number
- AT291247B AT291247B AT768868A AT768868A AT291247B AT 291247 B AT291247 B AT 291247B AT 768868 A AT768868 A AT 768868A AT 768868 A AT768868 A AT 768868A AT 291247 B AT291247 B AT 291247B
- Authority
- AT
- Austria
- Prior art keywords
- pyrazin
- imidazo
- ones
- preparation
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65904267A | 1967-08-08 | 1967-08-08 | |
| US72803368A | 1968-05-09 | 1968-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT291247B true AT291247B (de) | 1971-07-12 |
Family
ID=27097746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT768868A AT291247B (de) | 1967-08-08 | 1968-08-06 | Verfahren zur Herstellung von neuen 1H-Imidazo[4,5-b]pyrazin-2-onen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3507866A (de) |
| AT (1) | AT291247B (de) |
| BE (1) | BE719154A (de) |
| CH (1) | CH516574A (de) |
| DE (1) | DE1795062A1 (de) |
| DK (1) | DK123484B (de) |
| ES (1) | ES356976A1 (de) |
| FR (2) | FR1578366A (de) |
| GB (1) | GB1193035A (de) |
| IL (1) | IL30463A0 (de) |
| NL (1) | NL6810650A (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) * | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US7923041B2 (en) * | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| ES2439590T3 (es) | 2006-08-02 | 2014-01-23 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y métodos |
| CN101522681B (zh) * | 2006-08-02 | 2012-10-03 | 赛特凯恩蒂克公司 | 特定的化学个体、组合物和方法 |
| JP5513118B2 (ja) * | 2006-10-19 | 2014-06-04 | シグナル ファーマシューティカルズ，エルエルシー | ヘテロアリール化合物、その組成物、及びプロテインキナーゼ阻害剤としてのそれらの使用 |
| WO2008121333A1 (en) * | 2007-03-30 | 2008-10-09 | Cytokinetics, Incorporated | Certain chemical entities, compositions and methods |
| US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| SG10201500511TA (en) * | 2009-10-26 | 2015-03-30 | Signal Pharm Llc | Methods Of Synthesis And Purification Of Heteroaryl Compounds |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| PH12014500094A1 (en) | 2011-07-13 | 2014-03-17 | Cytokinetics Inc | Combination als therapy |
| MX357833B (es) | 2011-10-19 | 2018-07-26 | Signal Pharm Llc | Tratamiento del cancer con inhibidores de tor cinasa. |
| CA3125862A1 (en) | 2011-12-02 | 2013-06-06 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
| EA028462B1 (ru) | 2012-02-24 | 2017-11-30 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способы лечения немелкоклеточного рака легких на поздних стадиях c применением комбинированного лечения с ингибитором киназы tor |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| NZ709197A (en) | 2012-12-17 | 2020-06-26 | Parion Sciences Inc | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| WO2014099676A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| NZ630467A (en) | 2013-01-16 | 2017-02-24 | Signal Pharm Llc | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith |
| CA2908742C (en) | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| AU2014253978B2 (en) | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Combination therapy comprising a TOR kinase inhibitor and a 5-Substituted Quinazolinone Compound for treating cancer |
| EP2986319A1 (de) | 2013-04-17 | 2016-02-24 | Signal Pharmaceuticals, LLC | Kombinationstherapie mit einem torkinaseinhibitor und n-(3-(5-fluor-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamid zur behandlung von krebs |
| AU2014254053B2 (en) | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Treatment of cancer with Dihydropyrazino-Pyrazines |
| MY189663A (en) | 2013-04-17 | 2022-02-23 | Signal Pharm Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
| CN113730412A (zh) | 2013-04-17 | 2021-12-03 | 西格诺药品有限公司 | 用二氢吡嗪并-吡嗪治疗癌症 |
| CN105324381A (zh) | 2013-04-17 | 2016-02-10 | 西格诺药品有限公司 | 有关1-乙基-7-(2-甲基-6-(1H-1,2,4-三唑-3-基)吡啶-3-基)-3,4-二氢吡嗪并[2,3-b]吡嗪-2(1H)-酮的药物制剂、程序、固体形式和使用方法 |
| MX2015015880A (es) | 2013-05-29 | 2016-05-31 | Signal Pharm Llc | Composiciones farmaceuticas de 7-(6-(2-hidroxipropan-2-il)piridin- 3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino[2,3-b]pi razin-2(1h)-ona, una forma solida del mismo y metodos de su uso. |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| JP2017511367A (ja) | 2014-04-16 | 2017-04-20 | シグナル ファーマシューティカルズ，エルエルシー | １−エチル−７−（２−メチル−６−（１Ｈ−１，２，４−トリアゾール−３−イル）ピリジン−３−イル）−３，４−ジヒドロピラジノ［２，３−ｂ］ピラジン−２（１Ｈ）−オン及び共形成物を含む固体形態、その組成物及び使用方法 |
| US9737535B2 (en) | 2014-04-16 | 2017-08-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines |
| US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| CA2955009A1 (en) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| ES2959860T3 (es) | 2017-06-22 | 2024-02-28 | Celgene Corp | Tratamiento del carcinoma hepatocelular caracterizado por la infección por el virus de la hepatitis B |
-
1968
- 1968-05-09 US US728033A patent/US3507866A/en not_active Expired - Lifetime
- 1968-07-26 NL NL6810650A patent/NL6810650A/xx unknown
- 1968-07-29 IL IL30463A patent/IL30463A0/xx unknown
- 1968-08-05 DE DE19681795062 patent/DE1795062A1/de active Pending
- 1968-08-05 GB GB37296/68A patent/GB1193035A/en not_active Expired
- 1968-08-06 AT AT768868A patent/AT291247B/de not_active IP Right Cessation
- 1968-08-06 ES ES356976A patent/ES356976A1/es not_active Expired
- 1968-08-07 CH CH1183068A patent/CH516574A/de not_active IP Right Cessation
- 1968-08-07 DK DK379768AA patent/DK123484B/da unknown
- 1968-08-07 BE BE719154D patent/BE719154A/xx unknown
- 1968-08-08 FR FR1578366D patent/FR1578366A/fr not_active Expired
- 1968-11-08 FR FR173159A patent/FR8409M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6810650A (de) | 1969-02-11 |
| FR1578366A (de) | 1969-08-14 |
| FR8409M (de) | 1971-03-31 |
| IL30463A0 (en) | 1968-09-26 |
| US3507866A (en) | 1970-04-21 |
| DE1795062A1 (de) | 1972-03-30 |
| CH516574A (de) | 1971-12-15 |
| BE719154A (de) | 1969-02-07 |
| ES356976A1 (es) | 1970-10-16 |
| DK123484B (da) | 1972-06-26 |
| GB1193035A (en) | 1970-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT291247B (de) | Verfahren zur Herstellung von neuen 1H-Imidazo[4,5-b]pyrazin-2-onen | |
| CH505118A (de) | Verfahren zur Herstellung von 1,2,4-Triazin-5-onen | |
| AT275521B (de) | Verfahren zur Herstellung von neuen 1,4-Dihydropyridinderivaten | |
| CH481110A (de) | Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen | |
| CH502364A (de) | Verfahren zur Herstellung von neuen 1,2,4-Oxadiazolen | |
| AT281836B (de) | Verfahren zur Herstellung von neuen 2-Methyl-3-carbonsäureamido-chinoxalin-di-N-oxiden-(1,4) | |
| AT277221B (de) | Verfahren zur Herstellung von neuen 5-Nitro-2-furyl-2-isoxazolin-derivaten | |
| CH496022A (de) | Verfahren zur Herstellung von neuen N,N'-Diglycidyl-Verbindungen | |
| AT291250B (de) | Verfahren zur Herstellung von neuen 5-NR<1>R<2> -6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen | |
| AT277985B (de) | Verfahren zur Herstellung von neuen Nitro-furan-, -thiophen- oder -pyrrol-derivaten | |
| CH498132A (de) | Verfahren zur Herstellung neuer Pyrido (1,2-a)-s-triazindione | |
| AT284128B (de) | Verfahren zur Herstellung von neuen 2-Halogenmethyl-3-carbansäureamido-chinoxalin-di-N-oxiden-(1,4) | |
| AT280271B (de) | Verfahren zur Herstellung von neuen Cumarinyl-v-triazoloxydderivaten | |
| AT281838B (de) | Verfahren zur Herstellung von neuen 2-Isothiuronium-methyl-3-carbonsäureamido-chinoxalin-di-N-oxid-(1,4)-halogeniden | |
| AT299172B (de) | Verfahren zur Herstellung von neuen Naphthylisopropyl-Derivaten | |
| CH489525A (de) | Verfahren zur Herstellung von 1,8-Naphthyridinderivaten | |
| AT283356B (de) | Verfahren zur Herstellung von neuen 1,2,4-Oxdiazolidin-Derivaten | |
| CH508645A (de) | Verfahren zur Herstellung von neuen 5-substituierten y-Carbolinderivaten | |
| CH453370A (de) | Verfahren zur Herstellung von neuen 5,6-Dihydro-6-oxo-pyrido (2,3-b)(1,4)benzoxazepinen | |
| AT290026B (de) | Verfahren zur Herstellung von neuen 22-Amino-23,24-bisnorcholanderivaten | |
| AT293634B (de) | Verfahren zur Herstellung von neuen 17α-Acyloxy-11β-methyl-19-norpregn-4-en-3,20-dionen | |
| CH522619A (de) | Verfahren zur Herstellung von neuen Derivaten von 2a,3a-Epithioandrostanen | |
| AT291967B (de) | Verfahren zur Herstellung von neuen N-Phenyl-N-2-fluor-1,1,2,2,-tetrachloräthylsulfenyl-sulfamiden | |
| CH469729A (de) | Verfahren zur Herstellung von neuen 4,9-Dihydrothieno-(2,3-b)-benzo-(e)-thiepinderivaten | |
| AT281020B (de) | Verfahren zur Herstellung von neuen 3-Imino-1,2-benzisothiazolinen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |