AT219195B - Process for the production of a new medicament with cardiac effect - Google Patents

Description

  

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  Process for the production of a new medicament with cardiac action
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The stems of the ripe cherries are collected, looking for foreign objects and impurities
Possibility freed and dried. The air-dry drug is then finely ground, extracted with oxygen-containing organic solvents, advantageously with acetone, and the solvent is evaporated under mild conditions. The dry residue obtained can also be used in this state for the production of pharmaceutical preparations, but it still contains negligibly large amounts
Amounts of ineffective dietary fiber and therefore this product is expedient to an extraction with hydrocarbon solvents, e.g. B. with petroleum ether, subjected.

   The active ingredient is not dissolved in these solvents, whereas the dark, waxy fibers are soluble and can be removed in this way; after evaporation of the solvent, a lighter, yellow, residue which can be made into tablets and is more effective is obtained as the product. This product can then be processed into tablets, dragees or other pharmaceutically acceptable preparations in a manner known per se.



   In addition to acetone, other oxygen-containing organic solvents, such as alcohol or ether, can be used to extract the drug, but these are less selective and extract significantly more accompanying substances. The further processing of such extracts is therefore more difficult than that of the acetone extracts.



   The starting materials of the process according to the invention, the dried cherry stems, had been known as a drug for a long time under the name "Cerasi stipes" (Stipites cerasorum) and were also used as a tea substitute or as a herbal tea base. However, it was previously completely unknown that this drug contains an active ingredient that can be used as a cardiac drug, which can be extracted from the drug with oxygen-containing organic solvents and obtained in a solid, concentrated form.



   The practical implementation of the process according to the invention is explained in more detail by the following examples.



   Example 1: 2.5 kg of fresh, impurity-free cherry stalks are carefully air-dried and the air-dry drug, which has an ash content of about 4.6%, is roughly powdered. 100 g of the powdered drug are extracted in a Soxhlet apparatus with 700 ml of acetone on a water bath for 8 hours. The extract flowing off is initially dark green, then it gradually becomes lighter, and at the end of the extraction the solvent flows down completely colorless. The extract is concentrated to 1/4 volume, then the solvent is completely evaporated off under reduced pressure. A dry, light, brownish-green residue with a characteristic smell of hay is obtained, the amount of which is about 11 g.



   2.6 g of this dry extract residue are mixed with 10 g of powdered milk sugar and the homogenized mixture is pressed without further additives to give tablets with an average weight of 0.33 g. One tablet of these tablets is administered three times a day in the treatment of severe decompensation cases.



   Example 2: 100 g of the dry extract residue prepared according to Example 1 are extracted with petroleum ether in a Soxhlet apparatus until the liquid flowing off becomes almost or completely colorless.



  The petroleum ether remaining in the extracted product is evaporated under reduced pressure and the residue is powdered; about 75 g of a yellow powder are obtained which can be tabletted in a known manner. The active ingredient content of this product is about 33% higher than the active ingredient content of the product prepared according to Example 1.



   PATENT CLAIMS:
1. A process for the production of a new medicament with cardiac effect, characterized in that the fruit stalks of the cherry (Prunus avium) and / or the sour cherry (Prunus cerasus) - expediently in a dried and crushed state - with oxygen-containing organic solvents, preferably with acetone , and the extract is brought into a pharmaceutically usable form (tablets, dragees, aqueous solution, etc.).

 

Claims (1)

2. The method according to claim 1, characterized in that the collected fruit stalks of the ripe cherry are dried and crushed, then extracted with acetone and the residue obtained after evaporation of the solvent is extracted with petroleum ether or with other liquid hydrocarbons and that of waxy accompanying substances freed residue is processed into tablets or dragees in a manner known per se.