AT101982B - Process for the production of asymmetrically disubstituted barbituric acids. - Google Patents

Process for the production of asymmetrically disubstituted barbituric acids.

Info

Publication number: AT101982B
Authority: AT; Austria
Prior art keywords: production; barbituric acids; asymmetrically disubstituted; disubstituted barbituric; asymmetrically
Prior art date: 1924-03-21

Application number

Other languages

Original Assignee

Farbenfab Vorm Bayer F & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1924-03-21

Filing date

1925-02-04

Publication date

1925-12-10

1925-02-04 Application filed by Farbenfab Vorm Bayer F & Co filed Critical Farbenfab Vorm Bayer F & Co

1925-12-10 Application granted granted Critical

1925-12-10 Publication of AT101982B publication Critical patent/AT101982B/en

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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

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  Verfahren zur Herstellung von unsymmetrisch disubstituierten Barbitursäuren. 



   In dem D. R. P. Nr. 293163 sind u. a. unsymmetrisch disubstituierte Barbitursäuren beschreieben. die neben einem alicyklischen Radikal noch einen Alkylrest enthalten. 



   Es wurde nun gefunden, dass die bisher noch unbekannten, unsymmetrisch disubstituierten Barbitursäuren, welche neben einem   ungesättigten   alieyklischen Rest einen gesättigten oder ungesättigten, Alkylrest enthalten, in ihrer praktisch therapeutischen Wirkung den im D. R. P.   Nr.     293163 bechriebfnen   Verbindungen noch überlegen sind. Einerseits sind die neuen Verbindungen von geringerer Giftigkeit. anderseits ist die Qualität des   Schlafes   eine weit bessere. Insbesondere rufen die neuen   Verbindungen   nicht die   Rausch- und Aufregungsznstände   hervor, wie sie bei Anwendung der   Verbindungen   des D. R. P. 



  Nr. 293163 zu beobachten sind. 
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 der D. R. P. Nr. 247952 und Nr. 293163 ein. 



   Zur Darstellung der neuen Barbitursäurederivate verfährt man in der Weise, dass   man   die   ulsym-   metrisch disubstituierten Malonester bzw.   Cyanesigester   der allgemeinen Formeln 
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  Process for the production of asymmetrically disubstituted barbituric acids.



   In D.R.P. No. 293163 are i.a. a. Describe asymmetrically disubstituted barbituric acids. which in addition to an alicyclic radical also contain an alkyl radical.



   It has now been found that the hitherto unknown, asymmetrically disubstituted barbituric acids, which in addition to an unsaturated alicyclic radical contain a saturated or unsaturated alkyl radical, are still superior in their practical therapeutic effect to the compounds described in D.R.P. No. 293163. On the one hand, the new compounds are less toxic. on the other hand, the quality of sleep is far better. In particular, the new compounds do not induce the levels of intoxication and excitement that occur when using the compounds of the D.R.P.



  No. 293163 can be observed.
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 the D.R.P. No. 247952 and No. 293163.



   To prepare the new barbituric acid derivatives one proceeds in such a way that one uses the asymmetrically disubstituted malonic esters or cyano ester of the general formulas
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AT101982D 1924-03-21 1925-02-04 Process for the production of asymmetrically disubstituted barbituric acids. AT101982B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE101982X		1924-03-21

Publications (1)

Publication Number	Publication Date
AT101982B true AT101982B (en)	1925-12-10

Family

ID=5649138

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT101982D AT101982B (en)	1924-03-21	1925-02-04	Process for the production of asymmetrically disubstituted barbituric acids.

Country Status (1)

Country	Link
AT (1)	AT101982B (en)

1925
- 1925-02-04 AT AT101982D patent/AT101982B/en active

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