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AR241591A1 - Procedimiento pra la preparacion de nuevos derivados de piperazina con actividad antianafilactica y broncoespasmolitica. - Google Patents

Procedimiento pra la preparacion de nuevos derivados de piperazina con actividad antianafilactica y broncoespasmolitica.

Info

Publication number
AR241591A1
AR241591A1 AR86304331A AR30433186A AR241591A1 AR 241591 A1 AR241591 A1 AR 241591A1 AR 86304331 A AR86304331 A AR 86304331A AR 30433186 A AR30433186 A AR 30433186A AR 241591 A1 AR241591 A1 AR 241591A1
Authority
AR
Argentina
Prior art keywords
dialkylamine
alkyl
formula
amino
piperazine
Prior art date
Application number
AR86304331A
Other languages
English (en)
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Application granted granted Critical
Publication of AR241591A1 publication Critical patent/AR241591A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PIPERAZINA CON ACTIVIDAD ANTIANAFILACTICA Y BRONCOESPASMOLITICA DE FORMULA GENERAL (I) DONDE R ES H O ALQUILO A ES ALQUILO LINEAL O RAMIFICADA Y R1 Y R2 SON H, AMINO, ALQUILAMINO, DIALQUILAMINO, MONO- Y DI-(HIDROXIALQUIL) AMINO, MORFOLINO, PIPERIDINO, N-ALQUILPIPERAZINO, 1,3-DITIOLAN-2-ILIDENAMINO O N- ALQUILUREIDO; SUS MEZCLAS DE ISOMEROS Y ENANTIOMEROS INDIVIDUALES ASI COMO SUS SALES DE ADICION DE ACIDOS FARMACOLOGICAMENTE ACEPTABLES. SE HACE REACCIONAR N-BENZHIDRILPIPERAZINA DE FORMULA (II) CON UNA ACRILOILANILIDA DE FORMULA III, DONDE R, R1 Y R2 TIENE EL SIGNIFICADO YA DADO, R3 Y R4 SON H O ALQUILO O CON UN COMPUESTO DE FORMULA IV DONDE N ES 1 A 5, EN UN DISOLVENTE ADECUADO, DURANTE VARIAS HORAS, A UNA TEMPERATURA COMPRENDIDA ENTRE 50 Y 100 C Y AISLAR EL PRODUCTO ASI OBTENIDO Y PURIFICADO.
AR86304331A 1985-06-20 1986-06-19 Procedimiento pra la preparacion de nuevos derivados de piperazina con actividad antianafilactica y broncoespasmolitica. AR241591A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21225/85A IT1190375B (it) 1985-06-20 1985-06-20 N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica

Publications (1)

Publication Number Publication Date
AR241591A1 true AR241591A1 (es) 1992-09-30

Family

ID=11178661

Family Applications (1)

Application Number Title Priority Date Filing Date
AR86304331A AR241591A1 (es) 1985-06-20 1986-06-19 Procedimiento pra la preparacion de nuevos derivados de piperazina con actividad antianafilactica y broncoespasmolitica.

Country Status (24)

Country Link
US (1) US4675319A (es)
EP (1) EP0207901B1 (es)
JP (1) JPS61293977A (es)
KR (1) KR870000309A (es)
CN (1) CN1011784B (es)
AR (1) AR241591A1 (es)
AT (1) ATE58729T1 (es)
AU (1) AU592348B2 (es)
CA (1) CA1269980A (es)
DE (1) DE3675824D1 (es)
DK (1) DK291186A (es)
ES (1) ES8708218A1 (es)
FI (1) FI862204A (es)
GR (1) GR861391B (es)
HU (1) HU198033B (es)
IL (1) IL78804A (es)
IT (1) IT1190375B (es)
NO (1) NO163816C (es)
NZ (1) NZ216547A (es)
PH (1) PH22809A (es)
PT (1) PT82810B (es)
SG (1) SG7292G (es)
TN (1) TNSN86090A1 (es)
ZA (1) ZA863754B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0660160B2 (ja) * 1985-12-13 1994-08-10 テルモ株式会社 アミド誘導体およびこれを含有する抗アレルギ−剤
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
US4745191A (en) * 1987-09-30 1988-05-17 American Home Products Corporation 1-((A-substituted phenyl-ω-substituted piperazinyl)alkenyl) cyclohexanol
JP2767321B2 (ja) * 1991-07-19 1998-06-18 ゼリア新薬工業株式会社 ピペラジン誘導体及びこれを含有する医薬
KR19990010329A (ko) * 1997-07-16 1999-02-18 레나르트 태퀴스트 실리콘 질화물 절삭 공구 재료
WO2000006550A1 (fr) * 1998-07-31 2000-02-10 Nippon Soda Co., Ltd. Composes phenylazole, procede de production desdits composes et medicaments pour le traitement de l'hyperlipidemie
KR100384241B1 (ko) * 2000-10-31 2003-05-16 (주) 기산테크 저활동성 플라즈마 이온 방전을 이용한 오존발생장치
DE102006047618B3 (de) * 2006-10-09 2007-11-15 Clariant International Limited Verfahren zur Herstellung von Bisbenzoxazolen
DE102006047620B4 (de) 2006-10-09 2008-11-27 Clariant International Limited Verfahren zur Herstellung tertiärer Amide von Alkylphenylcarbonsäuren
DE102006047619B4 (de) * 2006-10-09 2008-11-13 Clariant International Limited Verfahren zur Herstellung basischer Fettsäureamide
DE102006047617B4 (de) * 2006-10-09 2008-11-27 Clariant International Limited Verfahren zur Herstellung basischer (Meth)acrylamide
MX2009003850A (es) * 2006-10-09 2009-04-23 Clariant Finance Bvi Ltd Metodo para producir alcanol amidas de acido graso.
KR101079459B1 (ko) * 2007-09-14 2011-11-03 이화여자대학교 산학협력단 신규한 화합물, 이의 제조방법 및 이를 포함하는 통증억제용 조성물
DE102008017217A1 (de) * 2008-04-04 2009-10-08 Clariant International Ltd. Kontinuierliches Verfahren zur Herstellung von Amiden aromatischer Carbonsäuren
DE102008017216B4 (de) * 2008-04-04 2013-08-14 Clariant International Ltd. Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden
DE102008017219A1 (de) * 2008-04-04 2009-10-08 Clariant International Ltd. Verfahren zur Herstellung von Amiden in Gegenwart von überhitztem Wasser
DE102008017218B4 (de) * 2008-04-04 2011-09-22 Clariant International Ltd. Kontinuierliches Verfahren zur Herstellung von Amiden niederer aliphatischer Carbonsäuren
DE102008017215B4 (de) * 2008-04-04 2012-08-09 Clariant International Ltd. Kontinuierliches Verfahren zur Herstellung von Amiden ethylenisch ungesättigter Carbonsäuren
DE102008017213B4 (de) * 2008-04-04 2012-08-09 Clariant International Limited Kontinuierliches Verfahren zur Herstellung von Amiden aliphatischer Hydroxycarbonsäuren
DE102008017214B4 (de) * 2008-04-04 2012-02-16 Clariant International Limited Kontinuierliches Verfahren zur Herstellung von Fettsäurealkanolamiden
CN101429164B (zh) * 2008-11-14 2013-03-20 广西大学 左旋二苯甲基哌嗪衍生物及其制备方法
DE102009031059A1 (de) 2009-06-30 2011-01-05 Clariant International Ltd. Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen
DE102009042523B4 (de) 2009-09-22 2012-02-16 Clariant International Ltd. Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen
DE102009042522A1 (de) 2009-09-22 2011-04-07 Clariant International Ltd. Kontinuierliches Umesterungsverfahren
DE102010056564A1 (de) 2010-12-30 2012-07-05 Clariant International Limited Hydroxylgruppen und Estergruppen tragende Polymere und Verfahren zu ihrer Herstellung
DE102010056565A1 (de) 2010-12-30 2012-07-05 Clariant International Ltd. Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
CN114621101A (zh) * 2020-12-11 2022-06-14 李冰坚 一种3,5-二甲基-1,2-苯二胺二盐酸盐的精制方法

Family Cites Families (9)

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US3244718A (en) * 1964-02-17 1966-04-05 Biel John Hans Piperazine derivatives
NL137318C (es) * 1964-06-09
DE2304154A1 (de) * 1973-01-29 1974-08-01 Ichthyol Ges Cordes Hermanni & Verfahren zur herstellung von substituierten piperazin- bzw. homopiperazinderivaten
JPS5070389A (es) * 1973-10-30 1975-06-11
GB2056968A (en) * 1979-08-21 1981-03-25 Fujisawa Pharmaceutical Co Piperazine derivative, processes for the preparation thereof and pharmaceutical composition comprising the same
US4411900A (en) * 1980-01-03 1983-10-25 Fujisawa Pharmaceutical Co., Ltd. Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical composition comprising the same
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent

Also Published As

Publication number Publication date
ES8708218A1 (es) 1987-10-01
IL78804A (en) 1991-12-15
HU198033B (en) 1989-07-28
IL78804A0 (en) 1986-09-30
JPS61293977A (ja) 1986-12-24
CN1011784B (zh) 1991-02-27
TNSN86090A1 (fr) 1990-01-01
DK291186D0 (da) 1986-06-20
HUT43837A (en) 1987-12-28
ES556145A0 (es) 1987-10-01
CN86105641A (zh) 1987-04-01
EP0207901A1 (en) 1987-01-07
NO163816C (no) 1990-07-25
ATE58729T1 (de) 1990-12-15
IT1190375B (it) 1988-02-16
IT8521225A0 (it) 1985-06-20
FI862204A0 (fi) 1986-05-26
NO862427L (no) 1986-12-22
PT82810B (pt) 1988-04-21
NO163816B (no) 1990-04-17
SG7292G (en) 1992-03-20
AU592348B2 (en) 1990-01-11
CA1269980A (en) 1990-06-05
FI862204A (fi) 1986-12-21
US4675319A (en) 1987-06-23
ZA863754B (en) 1987-01-28
AU5882886A (en) 1986-12-24
NO862427D0 (no) 1986-06-18
KR870000309A (ko) 1987-02-17
NZ216547A (en) 1989-11-28
GR861391B (en) 1986-09-16
DK291186A (da) 1986-12-21
PT82810A (en) 1986-07-01
PH22809A (en) 1988-12-27
DE3675824D1 (de) 1991-01-10
EP0207901B1 (en) 1990-11-28

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