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AR128995A1 - FUSION PROTEINS AND THEIR USE AGAINST EIMERIA - Google Patents

FUSION PROTEINS AND THEIR USE AGAINST EIMERIA

Info

Publication number
AR128995A1
AR128995A1 ARP230100842A ARP230100842A AR128995A1 AR 128995 A1 AR128995 A1 AR 128995A1 AR P230100842 A ARP230100842 A AR P230100842A AR P230100842 A ARP230100842 A AR P230100842A AR 128995 A1 AR128995 A1 AR 128995A1
Authority
AR
Argentina
Prior art keywords
fusion proteins
single domain
feed
reducing
parasites
Prior art date
Application number
ARP230100842A
Other languages
Spanish (es)
Inventor
Christian Foergaard Nielsen
Sandra Wingaard Thrane
Lene Venke Kofod
Andreas Hougaard Laustsen-Kiel
Original Assignee
Novozymes As
Bactolife As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As, Bactolife As filed Critical Novozymes As
Publication of AR128995A1 publication Critical patent/AR128995A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a anticuerpos de dominio único que tienen una afinidad de unión por el antígeno micronema proteína 2 (MIC2) de parásitos Eimeria; a proteínas de fusión que comprenden componentes multímeros de los anticuerpos de dominio único; y al uso de las proteínas de fusión para la prevención de la coccidiosis en aves de corral. Reivindicación 11: Un método para aumentar la ración de conversión alimenticia (FCR) o la ganancia de peso corporal en animales que comprende administrar a dicho animal un pienso o aditivo para piensos que comprende un anticuerpo de dominio único definido por cualquiera de las reivindicaciones 1 a 4 o la proteína de fusión definida en cualquiera de las reivindicaciones 5 a 6. Reivindicación 15: Un método para reducir los parásitos o reducir el riesgo de infecciones en un animal de compañía, tal como, pero no limitado a, un perro, gato, pájaro o conejo, que comprende el uso de un aditivo para piensos definido por la reivindicación 7, o un medicamento definido por la reivindicación 13.The present invention relates to single domain antibodies having a binding affinity for the microneme protein 2 (MIC2) antigen of Eimeria parasites; to fusion proteins comprising multimeric components of the single domain antibodies; and to the use of the fusion proteins for the prevention of coccidiosis in poultry. Claim 11: A method of increasing feed conversion ratio (FCR) or body weight gain in animals comprising administering to said animal a feed or feed additive comprising a single domain antibody defined by any of claims 1 to 4 or the fusion protein defined in any of claims 5 to 6. Claim 15: A method of reducing parasites or reducing the risk of infections in a companion animal, such as, but not limited to, a dog, cat, bird or rabbit, comprising the use of a feed additive defined by claim 7, or a medicament defined by claim 13.

ARP230100842A 2022-04-07 2023-04-04 FUSION PROTEINS AND THEIR USE AGAINST EIMERIA AR128995A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22167086 2022-04-07
EP22184836 2022-07-14
EP22196738 2022-09-20

Publications (1)

Publication Number Publication Date
AR128995A1 true AR128995A1 (en) 2024-07-03

Family

ID=86053842

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230100842A AR128995A1 (en) 2022-04-07 2023-04-04 FUSION PROTEINS AND THEIR USE AGAINST EIMERIA

Country Status (2)

Country Link
AR (1) AR128995A1 (en)
WO (1) WO2023194388A1 (en)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016040A (en) 1969-12-10 1977-04-05 Colgate-Palmolive Company Preparation of enzyme-containing beads
GB1483591A (en) 1973-07-23 1977-08-24 Novo Industri As Process for coating water soluble or water dispersible particles by means of the fluid bed technique
GB1590432A (en) 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
DK263584D0 (en) 1984-05-29 1984-05-29 Novo Industri As ENZYMOUS GRANULATES USED AS DETERGENT ADDITIVES
US4713245A (en) 1984-06-04 1987-12-15 Mitsui Toatsu Chemicals, Incorporated Granule containing physiologically-active substance, method for preparing same and use thereof
DK122686D0 (en) 1986-03-17 1986-03-17 Novo Industri As PREPARATION OF PROTEINS
DK435587D0 (en) 1987-08-21 1987-08-21 Novo Industri As PROCEDURE FOR THE PREPARATION OF AN ENZYMOUS GRANULATE
DK435687D0 (en) 1987-08-21 1987-08-21 Novo Industri As ENZYM containing granules and processes for their preparation
DK78089D0 (en) 1989-02-20 1989-02-20 Novo Industri As DETERGENTAL GRANULATE AND PROCEDURES FOR PREPARING THEREOF
DK78189D0 (en) 1989-02-20 1989-02-20 Novo Industri As ENZYMOUS GRANULATE AND PROCEDURE FOR PREPARING THEREOF
ATE210723T1 (en) 1991-10-07 2001-12-15 Genencor Int COATED ENZYME CONTAINING GRANULES
US5879920A (en) 1991-10-07 1999-03-09 Genencor International, Inc. Coated enzyme-containing granule
FR2704860B1 (en) 1993-05-05 1995-07-13 Pasteur Institut NUCLEOTIDE SEQUENCES OF THE LOCUS CRYIIIA FOR THE CONTROL OF THE EXPRESSION OF DNA SEQUENCES IN A CELL HOST.
PT765394E (en) 1994-06-03 2002-03-28 Novozymes Biotech Inc PURIFIED MYCELIOPHTHORA LACASES AND NUCLEIC ACIDS THAT ENCODE THEM
JP4842414B2 (en) 1996-04-12 2011-12-21 ノボザイムス アクティーゼルスカブ Enzyme-containing granules and process for their production
US6602841B1 (en) 1997-12-20 2003-08-05 Genencor International, Inc. Granule with hydrated barrier material
EP1092007B1 (en) 1998-06-30 2003-11-26 Novozymes A/S A new improved enzyme containing granule
CN1293191C (en) 2000-02-08 2007-01-03 Dsmip资产公司 Use of acid-stable subtilisin proteases in animal feed
PL1804592T3 (en) 2004-09-27 2010-04-30 Novozymes As Enzyme granules
DE102016002322A1 (en) 2016-02-26 2017-08-31 Hüseyin Keskin Driving and / or flight simulator
EP3972996A1 (en) 2019-05-20 2022-03-30 Novobind Livestock Therapeutics, Inc. Antibodies against disease causing agents of poultry and uses thereof

Also Published As

Publication number Publication date
WO2023194388A1 (en) 2023-10-12

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