[go: up one dir, main page]

AR121088A1 - COMPOUNDS DERIVED FROM 2,3-DIHYDROFURO[2,3-c]PYRIDINE AS ANTIVIRAL AGENTS - Google Patents

COMPOUNDS DERIVED FROM 2,3-DIHYDROFURO[2,3-c]PYRIDINE AS ANTIVIRAL AGENTS

Info

Publication number
AR121088A1
AR121088A1 ARP210100132A ARP210100132A AR121088A1 AR 121088 A1 AR121088 A1 AR 121088A1 AR P210100132 A ARP210100132 A AR P210100132A AR P210100132 A ARP210100132 A AR P210100132A AR 121088 A1 AR121088 A1 AR 121088A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
hydrogen
alkyl
heterocyclic ring
cycloalkyl
Prior art date
Application number
ARP210100132A
Other languages
Spanish (es)
Inventor
Xuechao Xing
Guoqiang Wang
Ruichao Shen
Brett Granger
Jiang Long
Yat Sun Or
Yong He
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of AR121088A1 publication Critical patent/AR121088A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos derivados de 2,3-furo[2,3-c]piridina que poseen propiedades antivirales, en particular contra el virus sincicial respiratorio (RSV) y el metaneumovirus humano (HMPV); composición farmacéutica que comprende a uno de éstos compuestos y la utilización de los mismos para el tratamiento de infecciones por RSV y HMPV. Reivindicación 1: Un compuesto representado por la fórmula (1), o una sal de uso farmacéutico aceptable del mismo, donde: A es un arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; B es O ó S; R¹ y R² son cada uno independientemente hidrógeno o un alquilo C₁₋₄ opcionalmente sustituido; alternativamente, R¹ y R² son tomados juntos con el átomo de carbono al que están unidos para formar un anillo cíclico de 3 - 6 miembros opcionalmente sustituido; R³ se selecciona del grupo que comprende hidrógeno, hidroxi, y alcoxi C₁₋₆ opcionalmente sustituido; R⁴ se selecciona del grupo que comprende hidrógeno, alquilo C₁₋₆ opcionalmente sustituido, alquenilo C₁₋₆ opcionalmente sustituido, alquinilo C₁₋₆ opcionalmente sustituido, cicloalquilo C₃₋₆ opcionalmente sustituido y anillo heterocíclico de 3 - 6 miembros opcionalmente sustituido; Z se selecciona del grupo que comprende hidrógeno, halógeno, ciano, alquilo C₁₋₆ opcionalmente sustituido, cicloalquilo C₃₋₆ opcionalmente sustituido y alcoxi C₁₋₆ opcionalmente sustituido; E es un arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido o anillo heterocíclico opcionalmente sustituido; G es NR⁵R⁶; R⁵, R⁶ es cada uno independientemente seleccionado de: 1) hidrógeno, 2) alquilo C₁₋₆ opcionalmente sustituido, 3) cicloalquilo C₃₋₆ opcionalmente sustituido, 4) anillo heterocíclico de 3 - 6 miembros opcionalmente sustituido, 5) arilo opcionalmente sustituido, 6) heteroarilo opcionalmente sustituido, 7) -C(=O)R⁷, 8) -C(=O)OR⁷, 9) -C(=O)NHR⁷, 10) -C(=NH)R⁷, 11) -C(=NH)NHR⁷, 12) -C(=NH)NHCN, 13) -C(=NH)NHC(=O)R⁷, 14) -SO₂R⁷, y 15) -SO₂NHR⁷, alternativamente, R⁵ y R⁶ son tomados junto con el nitrógeno al que están unidos para formar un anillo heterocíclico de 3 - 8 miembros opcionalmente sustituido; donde, R⁷ se selecciona del grupo que comprende hidrógeno, alquilo C₁₋₆ opcionalmente sustituido, cicloalquilo C₃₋₆ opcionalmente sustituido, anillo heterocíclico de 3 - 6 miembros opcionalmente sustituido, arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; y n es 1, 2 ó 3.Compounds derived from 2,3-furo[2,3-c]pyridine that possess antiviral properties, in particular against respiratory syncytial virus (RSV) and human metapneumovirus (HMPV); pharmaceutical composition comprising one of these compounds and the use thereof for the treatment of RSV and HMPV infections. Claim 1: A compound represented by formula (1), or a pharmaceutically acceptable salt thereof, wherein: A is an optionally substituted aryl or optionally substituted heteroaryl; B is O or S; R¹ and R² are each independently hydrogen or optionally substituted C₁₋₄ alkyl; alternatively, R¹ and R² are taken together with the carbon atom to which they are attached to form an optionally substituted 3-6 membered cyclic ring; R³ is selected from the group consisting of hydrogen, hydroxy, and optionally substituted C₁₋₆ alkoxy; R⁴ is selected from the group consisting of hydrogen, optionally substituted C₁₋₆ alkyl, optionally substituted C₁₋₆ alkenyl, optionally substituted C₁₋₆ alkynyl, optionally substituted C₃₋₆ cycloalkyl, and optionally substituted 3-6 membered heterocyclic ring; Z is selected from the group consisting of hydrogen, halogen, cyano, optionally substituted C₁₋₆ alkyl, optionally substituted C₃₋₆ cycloalkyl, and optionally substituted C₁₋₆ alkoxy; E is an optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclic ring; G is NR⁵R⁶; R⁵, R⁶ is each independently selected from: 1) hydrogen, 2) optionally substituted C₁₋₆ alkyl, 3) optionally substituted C₃₋₆ cycloalkyl, 4) optionally substituted 3-6 membered heterocyclic ring, 5) optionally substituted aryl, 6) optionally substituted heteroaryl, 7) -C(=O)R⁷, 8) -C(=O)OR⁷, 9) -C(=O)NHR⁷, 10) -C(=NH)R⁷, 11) -C (=NH)NHR⁷, 12) -C(=NH)NHCN, 13) -C(=NH)NHC(=O)R⁷, 14) -SO₂R⁷, and 15) -SO₂NHR⁷, alternatively, R⁵ and R⁶ are taken together with the nitrogen to which they are attached to form an optionally substituted 3-8 membered heterocyclic ring; where, R⁷ is selected from the group consisting of hydrogen, optionally substituted C₁₋₆ alkyl, optionally substituted C₃₋₆ cycloalkyl, optionally substituted 3-6 membered heterocyclic ring, optionally substituted aryl, and optionally substituted heteroaryl; and n is 1, 2 or 3.

ARP210100132A 2020-01-24 2021-01-21 COMPOUNDS DERIVED FROM 2,3-DIHYDROFURO[2,3-c]PYRIDINE AS ANTIVIRAL AGENTS AR121088A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202062965457P 2020-01-24 2020-01-24

Publications (1)

Publication Number Publication Date
AR121088A1 true AR121088A1 (en) 2022-04-13

Family

ID=81345124

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210100132A AR121088A1 (en) 2020-01-24 2021-01-21 COMPOUNDS DERIVED FROM 2,3-DIHYDROFURO[2,3-c]PYRIDINE AS ANTIVIRAL AGENTS

Country Status (1)

Country Link
AR (1) AR121088A1 (en)

Similar Documents

Publication Publication Date Title
AR127309A2 (en) PYRDAZINONE DERIVATIVES
AR116993A2 (en) BICYCLIC HETEROCYCLES COMPOUNDS AND THEIR USES IN THERAPY
AR109788A1 (en) BENZO COMPOUNDS [B] THIOPHEN AS STING AGONISTS
AR092108A1 (en) PIRIDAZINE 1.4 DISSTITUTED, ANALOGS OF THE SAME AND METHODS TO TREAT DISEASES RELATED TO SMN DEFICIENCY
AR115296A1 (en) HETEROCYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR THE TREATMENT OF CANCER
AR084976A1 (en) SUBSTITUTED BIFENYLENE COMPOUNDS AND METHODS OF USE OF THE SAME FOR THE TREATMENT OF VIRAL DISEASES
AR067757A1 (en) IMIDAZO DERIVATIVES [4,5-C] PIRIDIN-2-ONA, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME AS ANTIVIRAL AGENTS.
AR102213A1 (en) INHIBITORS OF HEPARAN SULPHATE BIOSYNTHESIS FOR THE TREATMENT OF DISEASES
AR111850A1 (en) SUBSTITUTED TRIFLUOROMETILOXADIAZOLS TO FIGHT FITOPATHOGEN FUNGI
AR037181A1 (en) COMPOSITE OF 4-HETEROARIL- (5-MEMBERS) ACIL PIRROLIDINA, PHARMACEUTICAL FORMULATION THAT INCLUDES IT, USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT AND PROCEDURE FOR PREPARATION
NO20080871L (en) N- (Heteroaryl) -1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof
AR119728A1 (en) 3-AMINO-4H-BENZO[E][1,2,4]THIADAZINE 1,1-DIOXIDE DERIVATIVES AS MRGX2 INHIBITORS
MY193754A (en) Treatment for parkinson's disease
AR123648A1 (en) BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USES
AR040456A1 (en) PIRIDINE N-OXIDES 2,4-USEFUL DISPOSALS AS INHIBITORS OF REVERSE TRANSCRIPTASE OF THE HUMAN IMMUNODEFICIENCY VIRUS
AR099867A1 (en) FUSED IMIDAZOBENZOTIAZOLO COMPOUNDS
AR112794A1 (en) HETEROAROMATIC COMPOUNDS SUBSTITUTED WITH CYCLOOLEFINS AND THEIR USE IN THE TREATMENT OF DISEASES INDUCED BY IDH MUTATIONS
AR091534A1 (en) DERIVATIVES OF SULFONAMIDE AND METHODS OF USE OF THE SAME TO IMPROVE THE PHARMACOCINETICS OF A PHARMACO
AR109949A1 (en) PHENYLAMINE DERIVATIVES REPLACED IN POSITION 4 AND USE OF THE SAME TO PROTECT CROPS BY COMBATING UNWANTED PHYTOOPATHOGEN MICROORGANISMS
PE20210097A1 (en) N-SUBSTITUTED TETRAHYDROTHENOPYRIDINE DERIVATIVES AND THEIR USES
AR124189A1 (en) COMPOUNDS AND PROCEDURES FOR USE THEREOF
AR068381A1 (en) APPROPRIATE QUINOLINE COMPOUNDS TO TREAT DISORDERS THAT RESPOND TO THE MODULATION OF SEROTONINE 5-HT6 RECEPTOR
AR111826A1 (en) BICYCLIC COMPOUNDS 5.6 FUSIONATES AND COMPOSITIONS FOR THE TREATMENT OF PARASITARY DISEASES
AR121088A1 (en) COMPOUNDS DERIVED FROM 2,3-DIHYDROFURO[2,3-c]PYRIDINE AS ANTIVIRAL AGENTS
AR046770A1 (en) BENCIMIDAZOL 5- OR 6-SUBSTITUTED DERIVATIVES AS INHIBITORS OF THE REPLICATION OF RESPIRATORY SINCITIAL VIRUS