AR120896A1 - COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz - Google Patents
COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKzInfo
- Publication number
- AR120896A1 AR120896A1 ARP200103641A ARP200103641A AR120896A1 AR 120896 A1 AR120896 A1 AR 120896A1 AR P200103641 A ARP200103641 A AR P200103641A AR P200103641 A ARP200103641 A AR P200103641A AR 120896 A1 AR120896 A1 AR 120896A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- halogen
- methyl
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos derivados de piridazinil-tiazolcarboxamida con actividad inhibitoria de DGKz, composición farmacéutica e inhibidor de DGKz que comprende a uno de éstos compuestos y el uso de los mismos para el tratamiento del cáncer relacionado con la activación de células inmunitarias o del cáncer que ofrece resistencia a un tratamiento con anticuerpos anti PD1 / anticuerpos anti PD-L1. Reivindicación 1: Un compuesto de fórmula (1) o una sal de este, caracterizado por que: R¹ es un grupo de fórmula seleccionado del grupo de fórmulas (2), R² es un alquilo C₁₋₆, un cicloalquilo C₃₋₅, un -O-(alquilo C₁₋₆), metanosulfonilo, un halógeno-alquilo C₁₋₆ o un halógeno, R³ es I) un fenilo opcionalmente sustituido con un grupo que se selecciona del grupo que consiste en un alquilo C₁₋₆, un halógeno-alquilo C₁₋₆, un cicloalquilo C₃₋₅, un -O-(alquilo C₁₋₆), un -O-(halógeno-alquilo C₁₋₆), ciano, nitro, metanosulfonilo y un halógeno, II) un cicloalquilo C₃₋₈ opcionalmente sustituido con un grupo que se selecciona del grupo que consiste en alquilo C₁₋₆ y un halógeno, III) un piridilo opcionalmente sustituido con un grupo que se selecciona del grupo que consiste en un alquilo C₁₋₆, un halógeno alquilo C₁₋₆, un cicloalquilo C₃₋₅, un -O-(alquilo C₁₋₆), un -O-(halógeno alquilo C₁₋₆), ciano, nitro, metanosulfonilo y un halógeno, IV) un pirazolilo opcionalmente sustituido con un grupo que se selecciona del grupo que consiste en un alquilo C₁₋₆ y un halógeno, o V) un pirrolidinilo opcionalmente sustituido con un alquilo C₁₋₆, R⁴ es H o F, L es un enlace, CO, SO₂, O ó NH, X es CH₂, O ó N-metilo, Y es CH₂ u O, Rᵃ es H o metilo, Rᵇ es H, metilo, etilo o -(CH₂)₂O-CH₃, Rᶜ es H, metilo u oxetanilo, Rᵈ es H, metilo, -(CH₂)₂OH, -(CH₂)₂O-CH₃ u oxetanilo, m es 1 ó 2, y n es 1 ó 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233673 | 2019-12-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR120896A1 true AR120896A1 (es) | 2022-03-30 |
Family
ID=76574296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200103641A AR120896A1 (es) | 2019-12-25 | 2020-12-23 | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP4083038B1 (es) |
| JP (1) | JP6948659B1 (es) |
| KR (1) | KR20220119702A (es) |
| CN (3) | CN115626919A (es) |
| AR (1) | AR120896A1 (es) |
| AU (1) | AU2020413997A1 (es) |
| BR (1) | BR112022012637A2 (es) |
| CA (1) | CA3165889A1 (es) |
| CL (1) | CL2022001752A1 (es) |
| CO (1) | CO2022009124A2 (es) |
| CR (1) | CR20220328A (es) |
| DK (1) | DK4083038T3 (es) |
| DO (1) | DOP2022000137A (es) |
| EC (1) | ECSP22057324A (es) |
| ES (1) | ES2995459T3 (es) |
| FI (1) | FI4083038T3 (es) |
| HR (1) | HRP20241588T1 (es) |
| IL (1) | IL294136A (es) |
| JO (1) | JOP20220163A1 (es) |
| LT (1) | LT4083038T (es) |
| MX (1) | MX2022007993A (es) |
| PE (1) | PE20230163A1 (es) |
| PH (1) | PH12022551569A1 (es) |
| PL (1) | PL4083038T3 (es) |
| PT (1) | PT4083038T (es) |
| SA (1) | SA522433129B1 (es) |
| TW (3) | TW202136275A (es) |
| WO (1) | WO2021132422A1 (es) |
| ZA (1) | ZA202207543B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023509881A (ja) | 2019-12-24 | 2023-03-10 | カルナバイオサイエンス株式会社 | ジアシルグリセロールキナーゼ調節化合物 |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| JP2023522250A (ja) | 2020-04-24 | 2023-05-29 | バイエル・アクチエンゲゼルシヤフト | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
| AR124172A1 (es) | 2020-11-30 | 2023-02-22 | Astellas Pharma Inc | Compuesto de heteroarilcarboxamida |
| WO2022271684A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| EP4359411A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP2024520593A (ja) | 2021-06-23 | 2024-05-24 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリエルコール（ｄｉａｃｙｌｇｌｙｅｒｃｏｌ）キナーゼ調節化合物 |
| CN117396478A (zh) | 2021-06-23 | 2024-01-12 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| CN114621214B (zh) * | 2022-04-25 | 2024-04-26 | 宜春学院 | 一种抗菌席夫碱n-酰化物及其制备方法和应用 |
| WO2024108100A1 (en) * | 2022-11-18 | 2024-05-23 | Incyte Corporation | Heteroaryl fluoroalkenes as dgk inhibitors |
| WO2024151346A1 (en) * | 2023-01-12 | 2024-07-18 | Incyte Corporation | Heteroaryl fluoroalkenes as dgk inhibitors |
| WO2024165468A1 (en) | 2023-02-06 | 2024-08-15 | Bayer Aktiengesellschaft | Combination of ccr8 antibodies with dgk inhibitors in the treatment of cancer |
| WO2024199387A1 (zh) * | 2023-03-30 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
| WO2024208198A1 (zh) * | 2023-04-06 | 2024-10-10 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的噻唑类化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381401B2 (en) | 2004-01-08 | 2008-06-03 | The University Of Chicago | T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase |
| NZ556732A (en) * | 2005-01-25 | 2011-11-25 | Synta Pharmaceuticals Corp | Pyrazine compounds for inflammation and immune-related uses |
| EP1983980A4 (en) * | 2006-01-25 | 2010-05-05 | Synta Pharmaceuticals Corp | THIAZOL AND THIADIAZOL COMPOUNDS FOR USES IN RELATION TO INFLAMMATION AND IMMUNITY |
| KR20090004976A (ko) * | 2006-04-19 | 2009-01-12 | 아스테라스 세이야쿠 가부시키가이샤 | 아졸카르복사미드 유도체 |
| EP2078003B1 (en) * | 2006-10-31 | 2017-03-08 | Merck Sharp & Dohme Corp. | Anilinopiperazine derivatives and methods of use thereof |
| CA3104654A1 (en) * | 2018-06-27 | 2020-01-02 | Bristol-Myers Squibb Company | Substituted naphthyridinone compounds useful as t cell activators |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| AR124172A1 (es) * | 2020-11-30 | 2023-02-22 | Astellas Pharma Inc | Compuesto de heteroarilcarboxamida |
-
2020
- 2020-12-23 AR ARP200103641A patent/AR120896A1/es unknown
- 2020-12-24 TW TW109146029A patent/TW202136275A/zh unknown
- 2020-12-24 DK DK20906466.6T patent/DK4083038T3/da active
- 2020-12-24 FI FIEP20906466.6T patent/FI4083038T3/fi active
- 2020-12-24 PL PL20906466.6T patent/PL4083038T3/pl unknown
- 2020-12-24 MX MX2022007993A patent/MX2022007993A/es unknown
- 2020-12-24 TW TW112145679A patent/TW202413375A/zh unknown
- 2020-12-24 CA CA3165889A patent/CA3165889A1/en active Pending
- 2020-12-24 BR BR112022012637A patent/BR112022012637A2/pt unknown
- 2020-12-24 PH PH1/2022/551569A patent/PH12022551569A1/en unknown
- 2020-12-24 LT LTEPPCT/JP2020/048337T patent/LT4083038T/lt unknown
- 2020-12-24 JP JP2021531562A patent/JP6948659B1/ja active Active
- 2020-12-24 PT PT209064666T patent/PT4083038T/pt unknown
- 2020-12-24 ES ES20906466T patent/ES2995459T3/es active Active
- 2020-12-24 JO JOP/2022/0163A patent/JOP20220163A1/ar unknown
- 2020-12-24 EP EP20906466.6A patent/EP4083038B1/en active Active
- 2020-12-24 PE PE2022001161A patent/PE20230163A1/es unknown
- 2020-12-24 CR CR20220328A patent/CR20220328A/es unknown
- 2020-12-24 CN CN202211308277.1A patent/CN115626919A/zh active Pending
- 2020-12-24 CN CN202211308268.2A patent/CN115590854B/zh active Active
- 2020-12-24 AU AU2020413997A patent/AU2020413997A1/en active Pending
- 2020-12-24 KR KR1020227025714A patent/KR20220119702A/ko unknown
- 2020-12-24 TW TW112145680A patent/TW202413376A/zh unknown
- 2020-12-24 IL IL294136A patent/IL294136A/en unknown
- 2020-12-24 HR HRP20241588TT patent/HRP20241588T1/hr unknown
- 2020-12-24 WO PCT/JP2020/048337 patent/WO2021132422A1/ja active Application Filing
- 2020-12-24 CN CN202080011114.XA patent/CN113365994B/zh active Active
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2022
- 2022-06-23 SA SA522433129A patent/SA522433129B1/ar unknown
- 2022-06-24 DO DO2022000137A patent/DOP2022000137A/es unknown
- 2022-06-24 CL CL2022001752A patent/CL2022001752A1/es unknown
- 2022-06-30 CO CONC2022/0009124A patent/CO2022009124A2/es unknown
- 2022-07-07 ZA ZA2022/07543A patent/ZA202207543B/en unknown
- 2022-07-21 EC ECSENADI202257324A patent/ECSP22057324A/es unknown
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