AR116635A1 - Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen - Google Patents
Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienenInfo
- Publication number
- AR116635A1 AR116635A1 ARP190102897A ARP190102897A AR116635A1 AR 116635 A1 AR116635 A1 AR 116635A1 AR P190102897 A ARP190102897 A AR P190102897A AR P190102897 A ARP190102897 A AR P190102897A AR 116635 A1 AR116635 A1 AR 116635A1
- Authority
- AR
- Argentina
- Prior art keywords
- bromophenil
- piperazinil
- etoxy
- synthesis
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicación 1: Un proceso para preparar un compuesto de fórmula (1), en donde: R¹ y R² independientemente uno de otro representan un átomo de halógeno, un grupo alquilo C₁₋₆ lineal o ramificado, un grupo alcoxi C₁₋₆ lineal o ramificado, un grupo alcoxi C₁₋₆alcoxi C₁₋₆ lineal o ramificado, un grupo hidroxilo o un grupo ciano; R³ representa un grupo alquilo C₁₋₆ lineal o ramificado, que comprende la etapa de hacer reaccionar un compuesto de fórmula (2), en donde R¹ y R² son como se han definido anteriormente, con un compuesto de fórmula (3), en donde R³ es como se ha definido anteriormente, y X⁻ representa un contraión aniónico monovalente, en un disolvente, a alta temperatura en presencia de una base.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306354 | 2018-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR116635A1 true AR116635A1 (es) | 2021-05-26 |
Family
ID=63965576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190102897A AR116635A1 (es) | 2018-10-15 | 2019-10-11 | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11512062B2 (es) |
| EP (1) | EP3867233A1 (es) |
| JP (1) | JP7448532B2 (es) |
| KR (1) | KR20210076094A (es) |
| CN (1) | CN112930340B (es) |
| AR (1) | AR116635A1 (es) |
| AU (1) | AU2019362310B2 (es) |
| BR (1) | BR112021006467A2 (es) |
| CA (1) | CA3115608A1 (es) |
| EA (1) | EA202190989A1 (es) |
| IL (1) | IL282094B1 (es) |
| MA (1) | MA53897A (es) |
| MX (1) | MX2021004288A (es) |
| TW (1) | TWI856981B (es) |
| WO (1) | WO2020078875A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240019330A (ko) | 2021-06-11 | 2024-02-14 | 길리애드 사이언시즈, 인코포레이티드 | Mcl-1 저해제와 항체 약물 접합체의 조합 |
| CN117651554A (zh) | 2021-06-11 | 2024-03-05 | 吉利德科学公司 | Mcl-1抑制剂与抗癌剂的组合 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4401824A (en) * | 1982-03-08 | 1983-08-30 | The Upjohn Company | Benzopyran compounds, derivatives of prostaglandins |
| US6867203B2 (en) * | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| GB0500029D0 (en) * | 2005-01-04 | 2005-02-09 | Univ Belfast | Basic ionic liquids |
| US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| CN102304075A (zh) * | 2005-10-11 | 2012-01-04 | 因特蒙公司 | 病毒复制抑制剂 |
| JP5079265B2 (ja) * | 2006-06-13 | 2012-11-21 | ポリプラスチックス株式会社 | 安定化ポリアセタール樹脂の製造方法 |
| JP2012530728A (ja) * | 2009-06-26 | 2012-12-06 | グラクソ グループ リミテッド | スフィンゴシン１−リン酸受容体アゴニストとして用いられる５員ヘテロアリール誘導体 |
| MX2012005426A (es) * | 2009-11-11 | 2012-06-19 | Dainippon Sumitomo Pharma Co | Derivado de 8-azabiciclo[3.2.1]octan-8-carboxamida. |
| CN103547584B (zh) * | 2011-06-17 | 2017-02-15 | 流体公司 | 利用碳酸二烷基酯季铵化来合成杂离子化合物 |
| TWI464242B (zh) * | 2012-10-26 | 2014-12-11 | Ind Tech Res Inst | 負介電異方性液晶化合物、液晶顯示器、與光電裝置 |
| KR102006994B1 (ko) * | 2013-03-28 | 2019-08-02 | 주식회사 삼양사 | 신규 페난트렌 화합물, 이의 제조방법 및 이를 이용한 유기전자소자 |
| WO2015024203A1 (en) * | 2013-08-20 | 2015-02-26 | Leo Pharma A/S | Novel neurokinin 1 receptor antagonist compounds ii |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP6190076B2 (ja) | 2014-04-25 | 2017-08-30 | ファイザー・インク | 複素芳香族化合物およびそのドーパミンｄ１リガンドとしての使用 |
| JP6635949B2 (ja) * | 2014-06-04 | 2020-01-29 | トーマス・ヘレデイズ・スティフテルス・フォー・メディシンスク・フォルスクニング | 炎症性および自己免疫性の病気の処置のためのｍｔｈ１阻害剤 |
| FR3037959B1 (fr) | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037958B1 (fr) | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037956B1 (fr) | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3046792B1 (fr) | 2016-01-19 | 2018-02-02 | Les Laboratoires Servier | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2017180571A1 (en) * | 2016-04-11 | 2017-10-19 | Janssen Pharmaceutica Nv | Substituted benzothiophenyl derivatives as gpr40 agonists for the treatment of type ii diabetes |
| KR101891263B1 (ko) * | 2016-07-20 | 2018-08-23 | 주식회사 엘지화학 | 신규한 헤테로고리 화합물 및 이를 포함하는 유기발광 소자 |
| WO2018078064A1 (en) * | 2016-10-28 | 2018-05-03 | Les Laboratoires Servier | Liposomal formulation for use in the treatment of cancer |
| CN107573360B (zh) * | 2017-10-27 | 2019-08-09 | 都创(上海)医药科技有限公司 | 一种多靶点小分子化合物s63845的制备方法 |
-
2019
- 2019-10-11 AR ARP190102897A patent/AR116635A1/es unknown
- 2019-10-14 CA CA3115608A patent/CA3115608A1/en active Pending
- 2019-10-14 US US17/283,107 patent/US11512062B2/en active Active
- 2019-10-14 JP JP2021520367A patent/JP7448532B2/ja active Active
- 2019-10-14 MX MX2021004288A patent/MX2021004288A/es unknown
- 2019-10-14 IL IL282094A patent/IL282094B1/en unknown
- 2019-10-14 EP EP19784071.3A patent/EP3867233A1/en active Pending
- 2019-10-14 AU AU2019362310A patent/AU2019362310B2/en active Active
- 2019-10-14 TW TW108136946A patent/TWI856981B/zh active
- 2019-10-14 MA MA053897A patent/MA53897A/fr unknown
- 2019-10-14 BR BR112021006467-2A patent/BR112021006467A2/pt unknown
- 2019-10-14 WO PCT/EP2019/077729 patent/WO2020078875A1/en unknown
- 2019-10-14 EA EA202190989A patent/EA202190989A1/ru unknown
- 2019-10-14 KR KR1020217014515A patent/KR20210076094A/ko not_active Application Discontinuation
- 2019-10-14 CN CN201980067808.2A patent/CN112930340B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI856981B (zh) | 2024-10-01 |
| KR20210076094A (ko) | 2021-06-23 |
| JP7448532B2 (ja) | 2024-03-12 |
| CN112930340B (zh) | 2025-01-07 |
| NZ774813A (en) | 2024-07-26 |
| CA3115608A1 (en) | 2020-04-23 |
| EA202190989A1 (ru) | 2021-07-05 |
| IL282094A (en) | 2021-05-31 |
| TW202033506A (zh) | 2020-09-16 |
| AU2019362310B2 (en) | 2024-10-24 |
| AU2019362310A1 (en) | 2021-05-13 |
| US11512062B2 (en) | 2022-11-29 |
| US20210380549A1 (en) | 2021-12-09 |
| IL282094B1 (en) | 2024-11-01 |
| JP2022512694A (ja) | 2022-02-07 |
| EP3867233A1 (en) | 2021-08-25 |
| MA53897A (fr) | 2022-01-19 |
| MX2021004288A (es) | 2021-05-31 |
| WO2020078875A1 (en) | 2020-04-23 |
| BR112021006467A2 (pt) | 2021-07-13 |
| CN112930340A (zh) | 2021-06-08 |
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