AR113966A1 - EphA2 SPECIFIC BICYCLIC PEPTIDES LIGANDS - Google Patents
EphA2 SPECIFIC BICYCLIC PEPTIDES LIGANDSInfo
- Publication number
- AR113966A1 AR113966A1 ARP180103703A ARP180103703A AR113966A1 AR 113966 A1 AR113966 A1 AR 113966A1 AR P180103703 A ARP180103703 A AR P180103703A AR P180103703 A ARP180103703 A AR P180103703A AR 113966 A1 AR113966 A1 AR 113966A1
- Authority
- AR
- Argentina
- Prior art keywords
- epha2
- drug conjugates
- bicyclic peptides
- ligands
- peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 title abstract 3
- 102000051096 EphA2 Receptor Human genes 0.000 title 1
- 108010055196 EphA2 Receptor Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000050554 Eph Family Receptors Human genes 0.000 abstract 1
- 108091008815 Eph receptors Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a polipéptidos que están covalentemente unidos a andamios moleculares no aromáticos de manera que hay dos o más bucles de péptidos subtendidos entre puntos de fijación al andamio. En particular, la presente describe péptidos que son binders de elevada afinidad de la tirosin quinasa A2 del receptor de Eph (EphA2). También incluye conjugados de fármacos que comprenden dichos péptidos, conjugado con uno o más grupos efectores y/o funcionales, composiciones farmacéuticas que comprenden dichos ligandos péptidos y conjugados de fármacos, y el uso de dichos ligandos péptidos y conjugados de fármacos en la prevención, supresión o tratamiento, de una enfermedad o trastorno caracterizados por la sobre expresión de EphA2 en un tejido enfermo (tal como un tumor).This refers to polypeptides that are covalently linked to non-aromatic molecular scaffolds such that there are two or more subtended peptide loops between sites of attachment to the scaffold. In particular, this describes peptides that are high affinity binders of the Eph receptor tyrosine kinase A2 (EphA2). It also includes drug conjugates comprising said peptides, conjugated to one or more effector and / or functional groups, pharmaceutical compositions comprising said peptide ligands and drug conjugates, and the use of said peptide ligands and drug conjugates in prevention, suppression or treatment, of a disease or disorder characterized by the overexpression of EphA2 in diseased tissue (such as a tumor).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1721259.8A GB201721259D0 (en) | 2017-12-19 | 2017-12-19 | Bicyclic peptide ligands specific for EphA2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR113966A1 true AR113966A1 (en) | 2020-07-01 |
Family
ID=61008664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180103703A AR113966A1 (en) | 2017-12-19 | 2018-12-18 | EphA2 SPECIFIC BICYCLIC PEPTIDES LIGANDS |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR113966A1 (en) |
| GB (1) | GB201721259D0 (en) |
-
2017
- 2017-12-19 GB GBGB1721259.8A patent/GB201721259D0/en not_active Ceased
-
2018
- 2018-12-18 AR ARP180103703A patent/AR113966A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB201721259D0 (en) | 2018-01-31 |
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