AR113793A1 - Proceso para preparar benzotiofen-2-il boronato - Google Patents
Proceso para preparar benzotiofen-2-il boronatoInfo
- Publication number
- AR113793A1 AR113793A1 ARP180103104A ARP180103104A AR113793A1 AR 113793 A1 AR113793 A1 AR 113793A1 AR P180103104 A ARP180103104 A AR P180103104A AR P180103104 A ARP180103104 A AR P180103104A AR 113793 A1 AR113793 A1 AR 113793A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- react
- allowed
- thf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un proceso para preparar el benzotiofen-2-il boronato de fórmula (1) que sirve como intermediario para la producción de medicamentos y para la producción de medicamentos para el tratamiento y/o la profilaxis de trastornos proliferativos, como, por ejemplo, cáncer y enfermedades tumorales. Reivindicación 1: Un método de preparación de un compuesto de fórmula (1), caracterizado porque comprende los siguientes pasos: paso 5: en el que un compuesto de fórmula (2) se deja reaccionar, mediante la disolución de un compuesto de fórmula (2) en un solvente inerte como, por ejemplo, THF, y la adición de una base orgánica de metal como, por ejemplo, una solución de n-butil litio y un borato de trialquilo como, por ejemplo, borato de triisopropilo, opcionalmente en un solvente, como, por ejemplo, THF, con lo cual se proporciona un compuesto de fórmula (1); dicho compuesto de fórmula (2) se prepara mediante el siguiente paso 4: en el que un compuesto de fórmula (3), se deja reaccionar, opcionalmente en presencia de un solvente inerte, como, por ejemplo, THF, con uno o más agentes reductores, como, por ejemplo, una solución de sodio-bis(2-metoxi-etoxi)-aluminio-dihidruro, con lo cual se proporciona un compuesto de fórmula (4) y se deja reaccionar el compuesto de fórmula (4) con HCl acuoso en presencia de un solvente como, por ejemplo, tolueno, con lo cual se proporciona un compuesto de fórmula (5); y se deja reaccionar el compuesto de fórmula (5) con uno o más agentes reductores, como, por ejemplo, una solución de sodio-bis(2-metoxi-etoxi)-aluminio-dihidruro, con lo cual se proporciona un compuesto de fórmula (2).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17198336 | 2017-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR113793A1 true AR113793A1 (es) | 2020-06-10 |
Family
ID=60293714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180103104A AR113793A1 (es) | 2017-10-25 | 2018-10-25 | Proceso para preparar benzotiofen-2-il boronato |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11274110B2 (es) |
| EP (1) | EP3700894A1 (es) |
| JP (1) | JP2021500392A (es) |
| KR (1) | KR20200074128A (es) |
| CN (1) | CN111225907B (es) |
| AR (1) | AR113793A1 (es) |
| AU (1) | AU2018354780A1 (es) |
| BR (1) | BR112020008063A2 (es) |
| CA (1) | CA3084755A1 (es) |
| CL (1) | CL2020001093A1 (es) |
| CO (1) | CO2020004984A2 (es) |
| IL (1) | IL273952A (es) |
| JO (1) | JOP20200090A1 (es) |
| MX (1) | MX2020004285A (es) |
| PE (1) | PE20211268A1 (es) |
| SG (1) | SG11202002199RA (es) |
| TW (1) | TWI784074B (es) |
| UA (1) | UA126592C2 (es) |
| UY (1) | UY37949A (es) |
| WO (1) | WO2019081346A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| AU2021353004A1 (en) | 2020-09-30 | 2023-04-13 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030355A1 (it) * | 2003-07-18 | 2005-01-19 | Sigma Tau Ind Farmaceuti | Composti ad attivita' citotossica derivati della combretastatina. |
| CA2676906A1 (en) * | 2007-02-12 | 2008-08-21 | Intermune, Inc. | Novel inhibitors hepatitis c virus replication |
| CA2739058A1 (en) * | 2008-10-15 | 2010-04-22 | Kissei Pharmaceutical Co., Ltd. | Fused heterocyclic derivative and use thereof for medical purposes |
| UY34484A (es) | 2011-12-15 | 2013-07-31 | Bayer Ip Gmbh | Benzotienilo-pirrolotriazinas disustituidas y sus usos |
| US9598416B2 (en) * | 2011-12-15 | 2017-03-21 | Bayer Intellectual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment cancer |
-
2018
- 2018-10-18 WO PCT/EP2018/078586 patent/WO2019081346A1/en active Application Filing
- 2018-10-18 AU AU2018354780A patent/AU2018354780A1/en not_active Abandoned
- 2018-10-18 UA UAA202002884A patent/UA126592C2/uk unknown
- 2018-10-18 PE PE2020000736A patent/PE20211268A1/es unknown
- 2018-10-18 US US16/759,139 patent/US11274110B2/en active Active
- 2018-10-18 JO JOP/2020/0090A patent/JOP20200090A1/ar unknown
- 2018-10-18 SG SG11202002199RA patent/SG11202002199RA/en unknown
- 2018-10-18 KR KR1020207011684A patent/KR20200074128A/ko not_active Ceased
- 2018-10-18 BR BR112020008063-2A patent/BR112020008063A2/pt not_active IP Right Cessation
- 2018-10-18 MX MX2020004285A patent/MX2020004285A/es unknown
- 2018-10-18 CN CN201880069634.9A patent/CN111225907B/zh not_active Expired - Fee Related
- 2018-10-18 EP EP18786350.1A patent/EP3700894A1/en not_active Withdrawn
- 2018-10-18 JP JP2020523692A patent/JP2021500392A/ja active Pending
- 2018-10-18 CA CA3084755A patent/CA3084755A1/en active Pending
- 2018-10-24 TW TW107137491A patent/TWI784074B/zh not_active IP Right Cessation
- 2018-10-25 UY UY0001037949A patent/UY37949A/es not_active Application Discontinuation
- 2018-10-25 AR ARP180103104A patent/AR113793A1/es not_active Application Discontinuation
-
2020
- 2020-04-13 IL IL273952A patent/IL273952A/en unknown
- 2020-04-23 CO CONC2020/0004984A patent/CO2020004984A2/es unknown
- 2020-04-23 CL CL2020001093A patent/CL2020001093A1/es unknown
-
2022
- 2022-03-10 US US17/691,858 patent/US20220356194A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20211268A1 (es) | 2021-07-19 |
| RU2020115600A3 (es) | 2022-03-29 |
| BR112020008063A2 (pt) | 2020-11-03 |
| US11274110B2 (en) | 2022-03-15 |
| JP2021500392A (ja) | 2021-01-07 |
| US20200339606A1 (en) | 2020-10-29 |
| JOP20200090A1 (ar) | 2020-05-03 |
| CN111225907B (zh) | 2023-05-26 |
| AU2018354780A1 (en) | 2020-04-09 |
| WO2019081346A1 (en) | 2019-05-02 |
| TWI784074B (zh) | 2022-11-21 |
| UY37949A (es) | 2019-05-31 |
| CN111225907A (zh) | 2020-06-02 |
| UA126592C2 (uk) | 2022-11-02 |
| CA3084755A1 (en) | 2019-05-02 |
| RU2020115600A (ru) | 2021-11-25 |
| CL2020001093A1 (es) | 2020-10-23 |
| US20220356194A1 (en) | 2022-11-10 |
| IL273952A (en) | 2020-05-31 |
| MX2020004285A (es) | 2020-07-29 |
| CO2020004984A2 (es) | 2020-05-05 |
| TW201925211A (zh) | 2019-07-01 |
| EP3700894A1 (en) | 2020-09-02 |
| KR20200074128A (ko) | 2020-06-24 |
| SG11202002199RA (en) | 2020-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |