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AR109348A1 - Sulfonilureas y compuestos relacionados y sus usos - Google Patents

Sulfonilureas y compuestos relacionados y sus usos

Info

Publication number
AR109348A1
AR109348A1 ARP170102277A ARP170102277A AR109348A1 AR 109348 A1 AR109348 A1 AR 109348A1 AR P170102277 A ARP170102277 A AR P170102277A AR P170102277 A ARP170102277 A AR P170102277A AR 109348 A1 AR109348 A1 AR 109348A1
Authority
AR
Argentina
Prior art keywords
compounds
refers
independently selected
present
sulfonile
Prior art date
Application number
ARP170102277A
Other languages
English (en)
Inventor
David John Miller
Angus Murray Macleod
Kate Schroder
Avril Robertson
Matthew Cooper
Rebecca Coll
Luke ONEILL
Original Assignee
Univ Queensland
Provost Fellows Found Scholars & Other Members Board College Holy & Und
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2016900535A external-priority patent/AU2016900535A0/en
Application filed by Univ Queensland, Provost Fellows Found Scholars & Other Members Board College Holy & Und filed Critical Univ Queensland
Publication of AR109348A1 publication Critical patent/AR109348A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

La presente hace referencia a compuestos de fórmula (1), y sales, solvatos y profármacos farmacéuticamente aceptable de estos, en los que Q se selecciona de O, S y Se; J es S o Se; W¹ y W², cuando se encuentran presentes, se seleccionan de forma independiente de N y C; R¹ y R² se seleccionan de forma independiente del grupo que consiste en hidrógeno, alquilo C₁₋₁₂, alquenilo C₂₋₁₂, alquinilo C₂₋₁₂, arilo, heterociclilo, heteroarilo, cicloalquilo, cicloalquenilo, amino, amido, alquiltio, acilo, arilalquilo y acilamido, todos los cuales se pueden encontrar opcionalmente sustituidos; y en los que al menos uno de W¹ y W² se encuentra presente y es un átomo de nitrógeno y cuando R¹ o R² son restos cíclicos, W¹ o W² puede formar parte de la estructura anular. La presente también hace referencia a composiciones farmacéuticas que incluyen dichos compuestos, a métodos de tratamiento que emplean dichos compuestos, en particular, en lo que respecta a trastornos mediados por inflamasoma NLRP3, y a usos diagnósticos asociados.
ARP170102277A 2016-02-16 2017-08-15 Sulfonilureas y compuestos relacionados y sus usos AR109348A1 (es)

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CA3059458A1 (en) * 2017-05-24 2018-11-29 The University Of Queensland Novel compounds and uses
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