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AR106138A1 - Compuestos y métodos para inhibir jak - Google Patents

Compuestos y métodos para inhibir jak

Info

Publication number
AR106138A1
AR106138A1 ARP160102919A ARP160102919A AR106138A1 AR 106138 A1 AR106138 A1 AR 106138A1 AR P160102919 A ARP160102919 A AR P160102919A AR P160102919 A ARP160102919 A AR P160102919A AR 106138 A1 AR106138 A1 AR 106138A1
Authority
AR
Argentina
Prior art keywords
methyl
compounds
methods
ethyl
inhibit jak
Prior art date
Application number
ARP160102919A
Other languages
English (en)
Inventor
Edmundo Chuaqui Claudio
Marie Vasbinder Melissa
Lys Ruston Linette
Mcabe James
Grecu Tudor
Grant Kettl Jason
James Winter-Holt Jon
Donald Woessner Richard
Yang Wenzhan
Wu Dedong
Su Qibin
Kawatkar Sameer
Patrick Grimster Neil
K Nilsson Magnus
Birgitta Margareta Strand Annika
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR106138A1 publication Critical patent/AR106138A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), en donde R¹ es metilo o etilo; R² se selecciona de metilo, etilo, metoxilo y etoxilo; R³ se selecciona de hidrógeno, cloro, flúor, bromo y metilo; R⁴ se selecciona de metilo, etilo y -CH₂OCH₃; R⁵ y R⁶ son cada uno individualmente metilo o hidrógeno; y R⁷ se selecciona de metilo, etilo, -(CH₂)₂OH y -(CH₂)₂OCH₃; o una sal farmacéuticamente aceptable del mismo.
ARP160102919A 2015-09-25 2016-09-23 Compuestos y métodos para inhibir jak AR106138A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562232629P 2015-09-25 2015-09-25

Publications (1)

Publication Number Publication Date
AR106138A1 true AR106138A1 (es) 2017-12-13

Family

ID=56979589

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102919A AR106138A1 (es) 2015-09-25 2016-09-23 Compuestos y métodos para inhibir jak

Country Status (17)

Country Link
US (5) US9714236B2 (es)
EP (2) EP3353168B1 (es)
JP (1) JP6767491B2 (es)
CN (4) CN111646980B (es)
AR (1) AR106138A1 (es)
AU (1) AU2016328764B2 (es)
BR (1) BR112018005833B1 (es)
CA (1) CA2995430C (es)
DK (1) DK3353168T3 (es)
ES (1) ES2956642T3 (es)
HK (1) HK1259422A1 (es)
MX (1) MX2018003590A (es)
PT (1) PT3353168T (es)
RU (1) RU2760359C2 (es)
TW (1) TWI740843B (es)
WO (1) WO2017050938A1 (es)
ZA (1) ZA201800782B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3353168T3 (da) * 2015-09-25 2023-10-02 Dizal Jiangsu Pharmaceutical Co Ltd Forbindelser og fremgangsmåder til at inhibere jak
KR20220130249A (ko) 2016-05-26 2022-09-26 리커리엄 아이피 홀딩스, 엘엘씨 Egfr 억제제 화합물
EP4219470A1 (en) * 2017-01-17 2023-08-02 Astrazeneca AB Jak1 selective inhibitors
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
SG11202100240RA (en) 2018-07-18 2021-02-25 Astrazeneca Ab A xinafoate salt of a jak inhibiting compound
AU2019344878B2 (en) * 2018-09-21 2022-08-11 Shanghai Ennovabio Pharmaceuticals Co., Ltd. Aromatic heterocyclic compound with kinase inhibitory activity
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
WO2020211839A1 (en) * 2019-04-19 2020-10-22 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Jak1 selective kinase inhibitor
CN110627775A (zh) * 2019-10-24 2019-12-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN111961037B (zh) * 2020-09-17 2021-09-21 嘉兴特科罗生物科技有限公司 一种作为jak激酶抑制剂的药物化合物
EP4253375A4 (en) * 2020-11-26 2024-10-02 Artivila (ShenZhen) Innovation Center, Ltd. AMIDE COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
US20220288041A1 (en) * 2021-03-11 2022-09-15 Janssen Pharmaceutica Nv Small molecule inhibitor of the jak family of kinases
CN115260128B (zh) * 2022-09-21 2022-12-09 苏州凯瑞医药科技有限公司 一种新型jak抑制剂关键中间体的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2786995A1 (en) * 2004-03-30 2014-10-08 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of JAK and other protein kinases
GB0500492D0 (en) * 2005-01-11 2005-02-16 Cyclacel Ltd Compound
US20080287475A1 (en) 2005-10-28 2008-11-20 Astrazeneca Ab 4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer
CA2640398A1 (en) * 2006-01-30 2007-08-09 Exelixis, Inc. 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and pharmaceutical compositions containing them
PT2091918E (pt) * 2006-12-08 2014-11-24 Irm Llc Compostos e composições como inibidores de proteína cinase
KR101705158B1 (ko) * 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
WO2010135650A1 (en) * 2009-05-22 2010-11-25 Incyte Corporation N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
TWI466885B (zh) * 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
US20130225615A1 (en) * 2010-09-01 2013-08-29 Ambit Biosciences Corporation 2-cycloquinazoline derivatives and methods of use thereof
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
EP2638018A1 (en) * 2010-11-09 2013-09-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
SG190839A1 (en) * 2010-11-19 2013-07-31 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
US20140045908A1 (en) * 2011-02-25 2014-02-13 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
AU2012273164B2 (en) * 2011-06-20 2015-05-28 Incyte Holdings Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
PT2830662T (pt) 2012-03-29 2018-11-29 Univ Columbia Métodos para tratamento de distúrbios de perda de pelo
DK3353168T3 (da) * 2015-09-25 2023-10-02 Dizal Jiangsu Pharmaceutical Co Ltd Forbindelser og fremgangsmåder til at inhibere jak

Also Published As

Publication number Publication date
EP3353168B1 (en) 2023-08-30
ES2956642T3 (es) 2023-12-26
KR20180058719A (ko) 2018-06-01
CN111646980B (zh) 2021-08-27
JP6767491B2 (ja) 2020-10-14
US20190092760A1 (en) 2019-03-28
CN111646980A (zh) 2020-09-11
US20170088543A1 (en) 2017-03-30
US9714236B2 (en) 2017-07-25
RU2018112993A3 (es) 2020-01-30
BR112018005833B1 (pt) 2023-10-10
CA2995430A1 (en) 2017-03-30
CN111606893B (zh) 2021-05-04
US10654835B2 (en) 2020-05-19
US20210078981A1 (en) 2021-03-18
CN111848586B (zh) 2024-05-03
TWI740843B (zh) 2021-10-01
TW201730186A (zh) 2017-09-01
US20170320857A1 (en) 2017-11-09
US10167276B2 (en) 2019-01-01
EP4219482A1 (en) 2023-08-02
DK3353168T3 (da) 2023-10-02
RU2018112993A (ru) 2019-10-28
CA2995430C (en) 2023-07-11
RU2760359C2 (ru) 2021-11-24
US20220119372A1 (en) 2022-04-21
CN111606893A (zh) 2020-09-01
AU2016328764B2 (en) 2020-07-09
MX2018003590A (es) 2018-11-29
US11247983B2 (en) 2022-02-15
HK1259422A1 (zh) 2019-11-29
CN108368091A (zh) 2018-08-03
CN108368091B (zh) 2020-08-11
PT3353168T (pt) 2023-09-20
BR112018005833A2 (pt) 2018-10-16
WO2017050938A1 (en) 2017-03-30
AU2016328764A1 (en) 2018-02-22
JP2018529770A (ja) 2018-10-11
CN111848586A (zh) 2020-10-30
EP3353168A1 (en) 2018-08-01
ZA201800782B (en) 2018-12-19

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