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AR104293A1 - Indazolonas como moduladores de la señalización de tnf - Google Patents

Indazolonas como moduladores de la señalización de tnf

Info

Publication number
AR104293A1
AR104293A1 ARP160101042A ARP160101042A AR104293A1 AR 104293 A1 AR104293 A1 AR 104293A1 AR P160101042 A ARP160101042 A AR P160101042A AR P160101042 A ARP160101042 A AR P160101042A AR 104293 A1 AR104293 A1 AR 104293A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
independently
indazolonas
modulators
Prior art date
Application number
ARP160101042A
Other languages
English (en)
Inventor
Wilson Noel
Vasudevan Anil
Osuma Augustine
Kinsman David
Ihle David
M Friedman Michael
Dietrich Justin
Burcht Andrew
C Breinlinger Eric
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of AR104293A1 publication Critical patent/AR104293A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los compuestos de la divulgación son útiles para tratar condiciones inmunológicas y oncológicas. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), o una sal farmacéuticamente aceptable, profármaco o estereoisómero del mismo, donde: X, Y y Z son en forma independiente CR⁴ o N; con la condición de que Y y Z no son ambos N; A es -C(Rᶻ)₂-; E es CH₂ ó O y G es CH; o E es CH₂ y G es CH o N; R¹ es arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; R² es -R²ᵃ-R²ᵇ, donde: R²ᵃ es un heterociclilo saturado, insaturado o parcialmente saturado opcionalmente sustituido o heteroarilo opcionalmente sustituido; R²ᵇ es N(Rᵃ)(Rᵇ), -O(Rᵃ), C₁₋₅ alquilo opcionalmente sustituido C₃₋₆ cicloalquilo opcionalmente sustituido, -(CH₂)ₚ-heteroarilo opcionalmente sustituido o -(CH₂)ₚ-heterociclo opcionalmente sustituido; donde Rᵃ y Rᵇ se seleccionan en forma independiente entre H, C₁₋₅ alquilo opcionalmente sustituido, y -(CH₂)ₙ-heterociclo opcionalmente sustituido; R⁴ es en forma independiente H, halo, CF₃, o C₁₋₃ alquilo; Rᶻ es en forma independiente H, halo, CF₃, o C₁₋₃ alquilo; n es 0 ó 1; y p es 0 ó 1.
ARP160101042A 2015-04-17 2016-04-15 Indazolonas como moduladores de la señalización de tnf AR104293A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562149336P 2015-04-17 2015-04-17

Publications (1)

Publication Number Publication Date
AR104293A1 true AR104293A1 (es) 2017-07-12

Family

ID=55854798

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160101042A AR104293A1 (es) 2015-04-17 2016-04-15 Indazolonas como moduladores de la señalización de tnf

Country Status (6)

Country Link
US (2) US9879016B2 (es)
EP (1) EP3286195A1 (es)
AR (1) AR104293A1 (es)
TW (1) TW201702247A (es)
UY (1) UY36628A (es)
WO (1) WO2016168638A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY36629A (es) 2015-04-17 2016-11-30 Abbvie Inc Indazolonas como moduladores de la señalización de tnf
US9856253B2 (en) 2015-04-17 2018-01-02 Abbvie, Inc. Tricyclic modulators of TNF signaling
AR104293A1 (es) 2015-04-17 2017-07-12 Abbvie Inc Indazolonas como moduladores de la señalización de tnf
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
CN113788777B (zh) * 2021-09-07 2023-04-11 华中科技大学 一种制备1-取代-3-羰基吡咯的方法

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Also Published As

Publication number Publication date
US9879016B2 (en) 2018-01-30
US20160304526A1 (en) 2016-10-20
US10273238B2 (en) 2019-04-30
UY36628A (es) 2016-11-30
WO2016168638A1 (en) 2016-10-20
TW201702247A (zh) 2017-01-16
US20180215764A1 (en) 2018-08-02
EP3286195A1 (en) 2018-02-28

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