AR102550A1 - Planta transgénica que comprende un polinucleótido que codifica un dominio variable de anticuerpo de cadena pesada - Google Patents
Planta transgénica que comprende un polinucleótido que codifica un dominio variable de anticuerpo de cadena pesadaInfo
- Publication number
- AR102550A1 AR102550A1 ARP150103596A ARP150103596A AR102550A1 AR 102550 A1 AR102550 A1 AR 102550A1 AR P150103596 A ARP150103596 A AR P150103596A AR P150103596 A ARP150103596 A AR P150103596A AR 102550 A1 AR102550 A1 AR 102550A1
- Authority
- AR
- Argentina
- Prior art keywords
- plant
- tissue
- cell
- pathogen
- heavy chain
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 241000233866 Fungi Species 0.000 abstract 5
- 102000040430 polynucleotide Human genes 0.000 abstract 5
- 108091033319 polynucleotide Proteins 0.000 abstract 5
- 239000002157 polynucleotide Substances 0.000 abstract 5
- 244000052769 pathogen Species 0.000 abstract 4
- 244000000003 plant pathogen Species 0.000 abstract 4
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 230000001717 pathogenic effect Effects 0.000 abstract 2
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 abstract 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 abstract 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 abstract 1
- 229940106189 ceramide Drugs 0.000 abstract 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 abstract 1
- 229930183167 cerebroside Natural products 0.000 abstract 1
- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 abstract 1
- 150000002339 glycosphingolipids Chemical class 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003408 sphingolipids Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Cultivation Of Plants (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Reivindicación 1: Una planta o tejido vegetal o célula vegetal transgénico que comprende al menos un polinucleótido que comprende al menos una secuencia que codifica para un dominio variable de un anticuerpo de cadena pesada (VHH) que se une específicamente a un esfingolípido de un hongo, preferiblemente a una ceramida de un hongo, más preferiblemente a un glicoesfingolípido de un hongo, incluso más preferiblemente a un cerebrósido de un hongo, aún más preferiblemente a un glucocerebrósido de un hongo. Reivindicación 8: Partes cosechables y materiales de propagación de una planta o tejido vegetal o célula vegetal transgénico de acuerdo con una cualquiera de las reivindicaciones 1 a 7, que comprende al menos un polinucleótido como se lo define en una cualquiera de las reivindicaciones 1 a 7. Reivindicación 11: Un método para proteger al menos parte de una planta o tejido vegetal o célula vegetal de una infección con un patógeno de planta, para inhibir el crecimiento de un patógeno de planta en al menos parte de una planta o tejido vegetal o célula vegetal, y/o para incrementar la resistencia a patógenos de al menos parte de una planta o tejido vegetal o célula vegetal, que comprende expresar en al menos parte de la planta o tejido vegetal o célula vegetal al menos un polinucleótido que codifica un dominio variable de un anticuerpo de cadena pesada (VHH) que se une específicamente a un patógeno. Reivindicación 13: Uso de al menos un polinucleótido que codifica un dominio variable de un anticuerpo de cadena pesada (VHH) que se une específicamente a un patógeno, para proteger al menos parte de una planta o tejido vegetal o célula vegetal de una infección con un patógeno de planta, para inhibir el crecimiento de un patógeno de planta en al menos parte de una planta o tejido vegetal o célula vegetal, y/o para incrementar la resistencia a patógenos de al menos parte de una planta o tejido vegetal o célula vegetal, en donde el polinucleótido es expresado en al menos parte de la planta o tejido vegetal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14191959 | 2014-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102550A1 true AR102550A1 (es) | 2017-03-08 |
Family
ID=51845355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150103596A AR102550A1 (es) | 2014-11-05 | 2015-11-05 | Planta transgénica que comprende un polinucleótido que codifica un dominio variable de anticuerpo de cadena pesada |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10858666B2 (es) |
| EP (1) | EP3215624B1 (es) |
| JP (2) | JP7089877B2 (es) |
| AR (1) | AR102550A1 (es) |
| BR (1) | BR112017009330A2 (es) |
| CA (1) | CA2966548A1 (es) |
| WO (1) | WO2016071438A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2992101B1 (en) | 2013-04-29 | 2018-10-10 | Agrosavfe N.V. | Agrochemical compositions comprising antibodies binding to sphingolipids |
| US20180222966A1 (en) * | 2013-04-29 | 2018-08-09 | Agrosavfe N.V. | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
| CA2966548A1 (en) | 2014-11-05 | 2016-05-12 | Agrosavfe Nv | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
| US10017560B1 (en) | 2017-11-16 | 2018-07-10 | King Saud University | Nanobody against begomoviruses |
| WO2019161386A1 (en) * | 2018-02-19 | 2019-08-22 | New York University | Alpha-synuclein single domain antibodies |
| ES2992601T3 (en) | 2020-03-31 | 2024-12-16 | Biotalys NV | Anti-fungal polypeptides |
| CN113080114A (zh) * | 2021-04-12 | 2021-07-09 | 浙江大学 | 一种提高鱼类子代成活率的方法 |
| WO2023057601A1 (en) * | 2021-10-06 | 2023-04-13 | Biotalys NV | Anti-fungal polypeptides |
| EP4170039A1 (en) * | 2021-10-22 | 2023-04-26 | The Sainsbury Laboratory | Modifying the immune response in plants |
| WO2024118831A1 (en) * | 2022-11-30 | 2024-06-06 | Velozbio Company | Compositions and methods for protein production |
| WO2024145551A1 (en) | 2022-12-29 | 2024-07-04 | Biotalys NV | Agrochemical compositions |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| DE69334258D1 (de) | 1992-08-21 | 2009-02-26 | Univ Bruxelles | Immunoglobuline ohne Leichtkette |
| DK0698097T3 (da) | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| EP0782626A1 (en) * | 1994-09-19 | 1997-07-09 | Rijkslandbouwuniversiteit Wageningen | Gene constructs encoding crop-protecting agents, as well as transformed plants containing and expressing such constructs, and methods of controlling plague organisms and pathogens in crops |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| DK0937140T3 (da) | 1996-06-27 | 2008-01-28 | Vlaams Interuniv Inst Biotech | Antistofmolekyler, som interagerer specifikt med et målmolekyles aktive sted eller klöft |
| EP1051493A2 (en) | 1998-01-26 | 2000-11-15 | Unilever Plc | Method for producing antibody fragments |
| AU5209399A (en) | 1998-07-10 | 2000-02-01 | Cornell Research Foundation Inc. | Recombinant constructs and systems for secretion of proteins via type iii secretion systems |
| ES2246093T3 (es) | 1998-10-16 | 2006-02-01 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Patogenicida molecular que induce una resistencia a la enfermedad en las plantas. |
| BR9916765A (pt) | 1999-01-05 | 2001-09-25 | Unilever Nv | Processo para produzir um material imunoadsorvente, uso de uma proteìna que é ligada por meio de uma ligação covalente a um fragmento de anticorpo, material imunadsorvente, uso de um material, e, kit de teste diagnóstico |
| DE60013767T3 (de) | 1999-01-19 | 2009-07-09 | Unilever N.V. | Verfahren zur herstellung von antikörperfragmenten |
| CN1252264C (zh) | 1999-04-22 | 2006-04-19 | 荷兰联合利华有限公司 | 利用单价抗原－结合蛋白抑制病毒感染 |
| WO2001006844A1 (fr) | 1999-07-22 | 2001-02-01 | Japan As Represented By Director General Of National Institute Of Agrobiological Resources Ministry Of Agriculture, Forestry And Fisheries | Procede de transformation ultrarapide de monocotyledon |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| PT1233987E (pt) | 1999-11-29 | 2009-12-28 | Bac Ip B V | Imobilização de moléculas de ligação ao antigénio de um domínio |
| ATE342922T1 (de) | 1999-11-29 | 2006-11-15 | Unilever Nv | Immobilisierung von proteinen mit hilfe eines polypeptidsegments |
| EP1118669A3 (en) * | 1999-12-17 | 2001-08-29 | Unilever Plc | Production of camelid antibodies in plants |
| EP1134231B1 (en) | 2000-03-14 | 2009-04-15 | Unilever N.V. | Antibody heavy chain variable domains against human dietary lipases, and their uses |
| AU2001268855A1 (en) | 2000-05-26 | 2001-12-03 | National Research Council Of Canada | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| US20040053340A1 (en) | 2000-12-13 | 2004-03-18 | De Haard Johannes Joseph | Protein arrays |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| US7371849B2 (en) | 2001-09-13 | 2008-05-13 | Institute For Antibodies Co., Ltd. | Methods of constructing camel antibody libraries |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| AU2002351896A1 (en) | 2001-12-11 | 2003-06-23 | Ablynx N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| AU2002360068B2 (en) | 2001-12-21 | 2009-09-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Method for cloning of variable domain sequences |
| CA2471645A1 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
| AU2003224073C1 (en) * | 2002-04-22 | 2010-03-11 | AgroProtect GmbH | Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi |
| DE10234116A1 (de) | 2002-07-26 | 2004-02-12 | Land Rheinland-Pfalz vertreten durch die Staatliche Lehr- und Forschungsanstalt für Landwirtschaft, Weinbau und Gartenbau (SLFA) | Verfahren zur Expression von gegen virale Proteine gerichtete scFv-Fragmenten in Pflanzen und deren Verwendung |
| WO2004041867A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders |
| EP3299393A1 (en) | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1587838B1 (en) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
| JP4283127B2 (ja) | 2003-06-20 | 2009-06-24 | 独立行政法人科学技術振興機構 | 転写因子を転写抑制因子に変換するペプチド及びこれをコードするポリヌクレオチド、並びにその利用 |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| EP2148889A4 (en) | 2007-04-20 | 2010-06-23 | Hexima Ltd | MODIFIED PLANT DEFENSE |
| NZ580505A (en) * | 2007-04-20 | 2011-03-31 | Hexima Ltd | Modified plant defensin comprising a signal peptide, a mature domain from a Class I defensin and a C-terminal propeptide tail from a Class II plant defensin |
| CU23688A1 (es) * | 2008-03-28 | 2011-07-11 | Ct Ingenieria Genetica Biotech | Secuencias de ácido nucleico y aminoácidos para el control de agentes patógenos |
| WO2010019442A1 (en) | 2008-08-12 | 2010-02-18 | Plant Health Care, Inc. | Production, formulation, and uses of stable liquid harpin protein formulations |
| CA2749558C (en) | 2008-12-08 | 2019-01-15 | Complix Nv | Single-chain antiparallel coiled coil proteins |
| BRPI1012085A2 (pt) * | 2009-08-24 | 2019-09-24 | Fraunhofer Ges Forschung | anticorpo de resistência de plantas mediado por fusão contra oomycota |
| WO2011085070A2 (en) * | 2010-01-06 | 2011-07-14 | Virginia Tech Intellectual Properties, Inc. | Methods and compositions to improve the health of plants, animals and microbes by manipulating protein entry into symbionts and their hosts |
| CA2795480C (en) | 2010-04-06 | 2021-10-26 | Vrije Universiteit Brussel | Specific delivery of agrochemicals |
| WO2012011396A1 (ja) | 2010-07-20 | 2012-01-26 | 国立大学法人東京大学 | ナノ抗体を発現するトランスジェニックイネ |
| ES2634547T3 (es) | 2010-08-26 | 2017-09-28 | Agrosavfe N.V. | Composiciones para el tratamiento de semillas |
| US20130224226A1 (en) | 2010-08-26 | 2013-08-29 | Agrosavfe N.V. | Insect binding antibodies |
| CN103153044B (zh) * | 2010-10-08 | 2015-06-17 | 韩国生命工学研究院 | 源自巴西橡胶树的乳胶分泌组织特异性srpp启动子及其用途 |
| EP2763529A1 (en) | 2011-10-06 | 2014-08-13 | Agrosavfe N.V. | Manufacturing of specifically targeting microcapsules |
| US20180222966A1 (en) * | 2013-04-29 | 2018-08-09 | Agrosavfe N.V. | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
| EP2992101B1 (en) * | 2013-04-29 | 2018-10-10 | Agrosavfe N.V. | Agrochemical compositions comprising antibodies binding to sphingolipids |
| CA2966548A1 (en) | 2014-11-05 | 2016-05-12 | Agrosavfe Nv | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
-
2015
- 2015-11-05 CA CA2966548A patent/CA2966548A1/en active Pending
- 2015-11-05 EP EP15797886.7A patent/EP3215624B1/en active Active
- 2015-11-05 US US15/524,609 patent/US10858666B2/en active Active
- 2015-11-05 AR ARP150103596A patent/AR102550A1/es not_active Application Discontinuation
- 2015-11-05 WO PCT/EP2015/075800 patent/WO2016071438A2/en active Application Filing
- 2015-11-05 BR BR112017009330A patent/BR112017009330A2/pt not_active Application Discontinuation
- 2015-11-05 JP JP2017542328A patent/JP7089877B2/ja active Active
-
2020
- 2020-12-07 US US17/113,552 patent/US20210340556A1/en not_active Abandoned
- 2020-12-18 JP JP2020209923A patent/JP2021061843A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20180179551A1 (en) | 2018-06-28 |
| US10858666B2 (en) | 2020-12-08 |
| EP3215624C0 (en) | 2023-11-29 |
| WO2016071438A3 (en) | 2016-06-23 |
| JP2017536134A (ja) | 2017-12-07 |
| EP3215624B1 (en) | 2023-11-29 |
| WO2016071438A2 (en) | 2016-05-12 |
| JP2021061843A (ja) | 2021-04-22 |
| JP7089877B2 (ja) | 2022-06-23 |
| US20210340556A1 (en) | 2021-11-04 |
| EP3215624A2 (en) | 2017-09-13 |
| BR112017009330A2 (pt) | 2017-12-19 |
| CA2966548A1 (en) | 2016-05-12 |
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