AR093247A1 - Agente profilactico y/o terapeutico para sintomas conductuales y psicologicos asociados con la enfermedad neurodegenerativa o sintomas impulsivos asociados con enfermedad mental que contiene brexpiprazol o sales del mismo - Google Patents
Agente profilactico y/o terapeutico para sintomas conductuales y psicologicos asociados con la enfermedad neurodegenerativa o sintomas impulsivos asociados con enfermedad mental que contiene brexpiprazol o sales del mismoInfo
- Publication number
- AR093247A1 AR093247A1 ARP130103867A ARP130103867A AR093247A1 AR 093247 A1 AR093247 A1 AR 093247A1 AR P130103867 A ARP130103867 A AR P130103867A AR P130103867 A ARP130103867 A AR P130103867A AR 093247 A1 AR093247 A1 AR 093247A1
- Authority
- AR
- Argentina
- Prior art keywords
- symptoms associated
- neurodegenerative disease
- salts
- mental illness
- impulsive
- Prior art date
Links
- 230000004770 neurodegeneration Effects 0.000 title abstract 5
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 5
- 208000020016 psychiatric disease Diseases 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 208000024891 symptom Diseases 0.000 abstract 8
- 230000003542 behavioural effect Effects 0.000 abstract 4
- 238000011321 prophylaxis Methods 0.000 abstract 3
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 2
- -1 4-benzo [b] thiophene- 4-yl-piperazin-1-yl Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dermatology (AREA)
Abstract
La presente se refiere a un agente profiláctico y/o terapéutico para los síntomas conductuales y psicológicos asociados con enfermedad neurodegenerativa o síntomas impulsivos asociados con enfermedad mental, que contiene 7-[4-(4-benzo[b]tiofen-4-il-piperazin-1-il)butoxi)-1H-quinolin-2-ona o una de sus sales como un ingrediente activo. Reivindicación 1: Un método para la profilaxis y/o el tratamiento de síntomas conductuales y psicológicos asociados con enfermedad neurodegenerativa o síntomas impulsivos asociados con enfermedad mental, caracterizado porque comprende la administración de 7-[4-(4-benzo[b]tiofen-4-il-piperazin-1-il)butoxi}-1H-quinolin-2-ona o una de sus sales en una cantidad profilática o terapéuticamente efectiva a un paciente que necesita la profilaxis y/o el tratamiento de síntomas conductuales y psicológicos asociados con la enfermedad neurodegenerativa o síntomas impulsivos asociados con enfermedad mental. Reivindicación 51: Una composición farmacéutica para usar en la profilaxis y/o el tratamiento de síntomas conductuales y psicológicos asociados con enfermedad neurodegenerativa o síntomas impulsivos asociados con enfermedad mental, caracterizado porque comprende 7-[4-(4-benzo[b]tiofen-4-il-piperazin-1-il)butoxi)-1H-quinolin-2-ona o una de sus sales como un ingrediente activo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718305P | 2012-10-25 | 2012-10-25 | |
| US201361782467P | 2013-03-14 | 2013-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR093247A1 true AR093247A1 (es) | 2015-05-27 |
Family
ID=49585556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103867A AR093247A1 (es) | 2012-10-25 | 2013-10-24 | Agente profilactico y/o terapeutico para sintomas conductuales y psicologicos asociados con la enfermedad neurodegenerativa o sintomas impulsivos asociados con enfermedad mental que contiene brexpiprazol o sales del mismo |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US20150272946A1 (es) |
| EP (2) | EP2911670A1 (es) |
| JP (5) | JP6329140B2 (es) |
| KR (1) | KR102245016B1 (es) |
| CN (4) | CN104755082A (es) |
| AR (1) | AR093247A1 (es) |
| AU (1) | AU2013335613B2 (es) |
| BR (1) | BR112015008759A2 (es) |
| CA (1) | CA2889196C (es) |
| EA (1) | EA201590808A1 (es) |
| HK (1) | HK1212609A1 (es) |
| IL (1) | IL238402B (es) |
| JO (2) | JOP20210047A1 (es) |
| MX (1) | MX371279B (es) |
| MY (1) | MY180185A (es) |
| NZ (1) | NZ708321A (es) |
| PH (1) | PH12015500925B1 (es) |
| SG (2) | SG10201702828TA (es) |
| TW (1) | TWI643620B (es) |
| UA (1) | UA116549C2 (es) |
| WO (1) | WO2014065437A1 (es) |
| ZA (1) | ZA201503640B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE313532T1 (de) | 2003-07-22 | 2006-01-15 | Arena Pharm Inc | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| WO2009023253A2 (en) | 2007-08-15 | 2009-02-19 | Arena Pharmaceuticals Inc. | IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| HUE036506T2 (hu) | 2008-10-28 | 2018-07-30 | Arena Pharm Inc | 5-HT2A szerotonin receptor modulátort tartalmazó készítmények az ilyen receptor modulátorokkal kapcsolatos rendellenességek kezelésére |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| WO2015163486A1 (en) | 2014-04-22 | 2015-10-29 | Otsuka Pharmaceutical Co., Ltd. | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| WO2016115144A1 (en) * | 2015-01-12 | 2016-07-21 | Reviva Pharmaceuticals Inc. | Methods for treating alzheimer's disease |
| WO2016115150A1 (en) * | 2015-01-12 | 2016-07-21 | Reviva Pharmaceuticals Inc. | Methods for treating psychosis associated with parkinson's disease |
| CA2989343A1 (en) | 2015-06-12 | 2016-12-15 | Yandong Wen | Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder |
| JP2018520187A (ja) * | 2015-07-15 | 2018-07-26 | アクソヴァント サイエンシーズ ゲゼルシャフト ミット ベシュレンクテル ハフツングAxovant Sciences GmbH | 神経変性疾患と関連する幻覚の予防および処置のために有用な５−ｈｔ２ａセロトニン受容体のモジュレーターとしてのジアリールおよびアリールヘテロアリール尿素誘導体 |
| CN105175401A (zh) * | 2015-10-16 | 2015-12-23 | 北京康立生医药技术开发有限公司 | 一种依匹哌唑的制备方法 |
| GB201620095D0 (en) * | 2016-11-28 | 2017-01-11 | Terali Innov Sas And Univ De Strasbourg And Inserm (Inst Nat De La Sante Et De La Rech Medicale) And | Novel use |
| CN105541819B (zh) * | 2016-02-04 | 2018-09-14 | 浙江永宁药业股份有限公司 | 一种依匹唑派的制备方法及其中间体和中间体的制备方法 |
| ES2769286T3 (es) | 2016-12-20 | 2020-06-25 | Lts Lohmann Therapie Systeme Ag | Sistema terapéutico transdérmico que contiene asenapina |
| US11337932B2 (en) | 2016-12-20 | 2022-05-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| ES2881783T3 (es) | 2017-06-26 | 2021-11-30 | Lts Lohmann Therapie Systeme Ag | Sistema terapéutico transdérmico que contiene asenapina y polímero de acrílico y silicona |
| EP3720435B1 (en) | 2017-12-05 | 2024-03-06 | Sunovion Pharmaceuticals Inc. | Crystal forms and production methods thereof |
| SG11202005016SA (en) | 2017-12-05 | 2020-06-29 | Sunovion Pharmaceuticals Inc | Nonracemic mixtures and uses thereof |
| EP3501506B1 (en) | 2017-12-19 | 2019-10-09 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising brexpiprazole |
| MX2020014286A (es) | 2018-06-20 | 2021-03-25 | Lts Lohmann Therapie Systeme Ag | Sistema terapeutico transdermico que contiene asenapina. |
| CN114401717A (zh) | 2019-06-04 | 2022-04-26 | 赛诺维信制药公司 | 修饰释放配制品及其用途 |
| WO2021029020A1 (ja) * | 2019-08-13 | 2021-02-18 | 大塚製薬株式会社 | 経口医薬組成物 |
| EP4173620A4 (en) * | 2020-06-24 | 2024-07-10 | National University Corporation Hokkaido University | Blood-cerebrospinal fluid barrier protecting agent |
| CN112137994B (zh) * | 2020-09-15 | 2022-10-14 | 中山大学 | 小分子化合物在制备抗丝状病毒药物中的应用 |
| US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
| CN115429753B (zh) * | 2021-06-02 | 2024-08-06 | 山东百诺医药股份有限公司 | 布瑞哌唑口服混悬液 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| JP4540700B2 (ja) * | 2006-10-13 | 2010-09-08 | 大塚製薬株式会社 | 医薬 |
| JP2011136906A (ja) * | 2008-04-18 | 2011-07-14 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
| TWI636784B (zh) * | 2011-04-05 | 2018-10-01 | 大塚製藥股份有限公司 | 含7-〔4-(4-苯並〔b〕噻吩-4-基-哌-1-基)丁氧基〕-1H-喹啉-2-酮之醫藥組成物與套組，以及彼之用途 |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| EP2822136B1 (en) * | 2013-07-03 | 2018-08-29 | Siemens Aktiengesellschaft | Method and arrangement for transferring electrical power for subsea applications |
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2012
- 2012-10-25 JO JOP/2021/0047A patent/JOP20210047A1/ar unknown
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2013
- 2013-10-24 CN CN201380055961.6A patent/CN104755082A/zh active Pending
- 2013-10-24 KR KR1020157013570A patent/KR102245016B1/ko active Active
- 2013-10-24 AR ARP130103867A patent/AR093247A1/es unknown
- 2013-10-24 EP EP13792110.2A patent/EP2911670A1/en not_active Withdrawn
- 2013-10-24 UA UAA201505106A patent/UA116549C2/uk unknown
- 2013-10-24 US US14/438,335 patent/US20150272946A1/en not_active Abandoned
- 2013-10-24 SG SG10201702828TA patent/SG10201702828TA/en unknown
- 2013-10-24 EA EA201590808A patent/EA201590808A1/ru unknown
- 2013-10-24 TW TW102138482A patent/TWI643620B/zh active
- 2013-10-24 WO PCT/JP2013/079480 patent/WO2014065437A1/en active Application Filing
- 2013-10-24 CN CN201810366157.4A patent/CN108578408A/zh active Pending
- 2013-10-24 MY MYPI2015701327A patent/MY180185A/en unknown
- 2013-10-24 SG SG11201503152TA patent/SG11201503152TA/en unknown
- 2013-10-24 MX MX2015005174A patent/MX371279B/es active IP Right Grant
- 2013-10-24 JP JP2015521734A patent/JP6329140B2/ja active Active
- 2013-10-24 NZ NZ708321A patent/NZ708321A/en unknown
- 2013-10-24 BR BR112015008759A patent/BR112015008759A2/pt not_active Application Discontinuation
- 2013-10-24 CN CN202011339120.6A patent/CN112402421A/zh active Pending
- 2013-10-24 CN CN202210498926.2A patent/CN114712360A/zh active Pending
- 2013-10-24 CA CA2889196A patent/CA2889196C/en active Active
- 2013-10-24 JO JOP/2013/0313A patent/JOP20130313B1/ar active
- 2013-10-24 AU AU2013335613A patent/AU2013335613B2/en active Active
- 2013-10-24 EP EP21159914.7A patent/EP3848033A1/en active Pending
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2015
- 2015-04-21 IL IL238402A patent/IL238402B/en active IP Right Grant
- 2015-04-24 PH PH12015500925A patent/PH12015500925B1/en unknown
- 2015-05-22 ZA ZA2015/03640A patent/ZA201503640B/en unknown
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2016
- 2016-01-19 HK HK16100569.3A patent/HK1212609A1/zh unknown
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2017
- 2017-03-28 US US15/471,429 patent/US20170258787A1/en not_active Abandoned
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2018
- 2018-03-29 JP JP2018065319A patent/JP2018138555A/ja active Pending
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2019
- 2019-06-28 US US16/456,334 patent/US20190314367A1/en not_active Abandoned
- 2019-10-29 JP JP2019195831A patent/JP2020045345A/ja active Pending
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2021
- 2021-07-19 JP JP2021118416A patent/JP2021181448A/ja active Pending
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2022
- 2022-07-21 US US17/869,993 patent/US20220370442A1/en not_active Abandoned
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2023
- 2023-05-30 JP JP2023088455A patent/JP2023123441A/ja active Pending
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2024
- 2024-07-26 US US18/785,196 patent/US20250099459A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |