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AR085750A1 - Derivados de pirazolo-pirimidina - Google Patents

Derivados de pirazolo-pirimidina

Info

Publication number
AR085750A1
AR085750A1 ARP120101075A ARP120101075A AR085750A1 AR 085750 A1 AR085750 A1 AR 085750A1 AR P120101075 A ARP120101075 A AR P120101075A AR P120101075 A ARP120101075 A AR P120101075A AR 085750 A1 AR085750 A1 AR 085750A1
Authority
AR
Argentina
Prior art keywords
alkyl
pyrazolo
pyrimidine derivatives
diseases
angiogenesis
Prior art date
Application number
ARP120101075A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR085750A1 publication Critical patent/AR085750A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)

Abstract

La presente se refiere a derivados de pirazolo-pirimidina, a métodos para su preparación, a combinaciones y composiciones farmacéuticas que los comprenden, y a su uso en el tratamiento de enfermedades y trastornos que, por ejemplo, pueden involucrar enfermedades autoinmunes, angiogénesis, dolor, y/o enfermedades inflamatorias. Reivindicación 1: Un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde: R¹ es H o alquilo C₁₋₆; R² y R³ son, independientemente uno del otro, H o alquilo C₁₋₆; A es un grupo enlazador bivalente seleccionado a partir que consiste en: -CH=CH-, -CH=CH-CH₂-, -CH₂-CH=CH-, -CH₂-CH₂-CH₂-, -CH=CH-C(O)-, -C(O)-CH=CH-, -CH₂-CH₂-C(O)-, -C(O)-CH₂-CH₂-, -C(O)-NH-CH₂-, -CH₂-NH-C(O)-, -O-CH₂-, -CH₂-O-, -O-CH₂-CH₂-, CH₂-CH₂-O-, o del grupo de formulas (2) (donde un * denota el enlace (o los lugares de unión)); R representa heterociclilo o cicloalquilo, cada uno de los cuales puede estar opcionalmente sustituido de 1 a 4 veces; y R⁴ es H, alquilo C₁₋₆, alcoxilo C₁₋₆, halógeno, hidroxilo, ciano o trifluorometilo.
ARP120101075A 2011-04-01 2012-03-29 Derivados de pirazolo-pirimidina AR085750A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161470630P 2011-04-01 2011-04-01

Publications (1)

Publication Number Publication Date
AR085750A1 true AR085750A1 (es) 2013-10-23

Family

ID=45976462

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101075A AR085750A1 (es) 2011-04-01 2012-03-29 Derivados de pirazolo-pirimidina

Country Status (17)

Country Link
US (1) US8748435B2 (es)
EP (1) EP2694513B1 (es)
JP (1) JP5963843B2 (es)
KR (1) KR20140023331A (es)
CN (1) CN103502248B (es)
AR (1) AR085750A1 (es)
AU (1) AU2012235665A1 (es)
BR (1) BR112013025001A2 (es)
CA (1) CA2831929A1 (es)
EA (1) EA201391440A1 (es)
ES (1) ES2534444T3 (es)
MX (1) MX2013011421A (es)
PL (1) PL2694513T3 (es)
PT (1) PT2694513E (es)
TW (1) TW201245203A (es)
UY (1) UY33976A (es)
WO (1) WO2012131633A1 (es)

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CN108084186B (zh) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
GB201700692D0 (en) * 2017-01-16 2017-03-01 Salvensis Novel compounds and their use in the treatment of schistosomiasis
CN110636846B (zh) * 2017-05-17 2023-05-16 艾库斯生物科学有限公司 用于治疗癌症相关疾病的喹唑啉吡唑衍生物
CN113661163A (zh) * 2019-02-28 2021-11-16 国立大学法人大阪大学 用于修饰蛋白质和/或肽的分子
EP4267573A1 (en) 2020-12-23 2023-11-01 Genzyme Corporation Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

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CN103502248A (zh) 2014-01-08
TW201245203A (en) 2012-11-16
AU2012235665A1 (en) 2013-10-10
PL2694513T3 (pl) 2015-06-30
EP2694513B1 (en) 2015-01-07
EP2694513A1 (en) 2014-02-12
JP5963843B2 (ja) 2016-08-03
BR112013025001A2 (pt) 2017-01-17
PT2694513E (pt) 2015-04-09
UY33976A (es) 2012-10-31
KR20140023331A (ko) 2014-02-26
CA2831929A1 (en) 2012-10-04
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