AR084209A1 - Metodo para la sintesis de derivados de aminociclohexanona sustituidos - Google Patents
Metodo para la sintesis de derivados de aminociclohexanona sustituidosInfo
- Publication number
- AR084209A1 AR084209A1 ARP110104587A ARP110104587A AR084209A1 AR 084209 A1 AR084209 A1 AR 084209A1 AR P110104587 A ARP110104587 A AR P110104587A AR P110104587 A ARP110104587 A AR P110104587A AR 084209 A1 AR084209 A1 AR 084209A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- general formula
- synthesis
- denotes
- aminociclohexanone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicación 1: Método para la síntesis de un compuesto de la fórmula general (1) en que R1 denota -H o -CH3, y R2 denota -H, -Cl o -F; que comprende la etapa, (b) transformación de un compuesto de la fórmula (2) por medio de un compuesto de organolitio de la fórmula general (3), en que R2 denota -H, -Cl o -F; en un compuesto de la fórmula general (4) y transformación del compuesto de la fórmula general (4) en el compuesto de la fórmula general (1) eventualmente por medio de metilación de la función de amino y separación de la función de cetal.Reivindicación 10: Método para la síntesis de un compuesto de la fórmula general (5) en que R1 denota -H o -CH3, o de una sal fisiológicamente compatible comprendiendo el método de una de las reivindicaciones 1 a 9 y una reacción de Oxa-Pictet-Spengler catalizada por medio de ácido del compuesto de la fórmula general (1) por medio de un compuesto heteroaromático en el compuesto de la fórmula general (5).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10015428 | 2010-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084209A1 true AR084209A1 (es) | 2013-05-02 |
Family
ID=43856244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104587A AR084209A1 (es) | 2010-12-08 | 2011-12-07 | Metodo para la sintesis de derivados de aminociclohexanona sustituidos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8658827B2 (es) |
| EP (1) | EP2649044B1 (es) |
| CN (1) | CN103339102A (es) |
| AR (1) | AR084209A1 (es) |
| CA (1) | CA2820413C (es) |
| ES (1) | ES2653715T3 (es) |
| HU (1) | HUE033692T2 (es) |
| IL (1) | IL226721A (es) |
| PL (1) | PL2649044T3 (es) |
| PT (1) | PT2649044T (es) |
| SI (1) | SI2649044T1 (es) |
| WO (1) | WO2012076165A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017148595A1 (en) | 2016-02-29 | 2017-09-08 | Grünenthal GmbH | Titration of cebranopadol |
| MX2018015464A (es) * | 2016-06-13 | 2019-05-27 | Syneurx Int Taiwan Corp | Uso de benzoato de litio para tratar trastornos del sistema nervioso central. |
| WO2024129782A1 (en) | 2022-12-12 | 2024-06-20 | Park Therapeutics, Inc. | Regimens and compositions useful for alleviating pain |
| WO2024173714A1 (en) | 2023-02-15 | 2024-08-22 | Park Therapeutics, Inc. | Regimens and compositions useful for alleviating pain |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CA2553973A1 (en) | 2004-01-21 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Methods of treatment of amyloidosis using aspartyl-protease inihibitors |
| US20060128715A1 (en) | 2004-07-09 | 2006-06-15 | Jennifer Sealy | Oxime derivative hydroxyethylamine aspartyl-protease inhibitors |
| CA2573138A1 (en) | 2004-07-09 | 2006-01-26 | Elan Pharmaceuticals Inc. | Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors |
| DE102005013287B3 (de) * | 2005-01-27 | 2006-10-12 | Misselhorn, Jürgen, Dipl.Ing. | Wärmekraftmaschine |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102007009235A1 (de) * | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102007009319A1 (de) | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| TW200940523A (en) * | 2008-03-17 | 2009-10-01 | Gruenenthal Gmbh | Substituted sulfonamide derivatives |
| MX2010009955A (es) * | 2008-03-27 | 2010-09-30 | Gruenenthal Gmbh | Derivados de ciclohexano espirociclicos sustituidos. |
| CA2719736C (en) * | 2008-03-27 | 2016-02-09 | Gruenenthal Gmbh | Spiro(5.5)undecane derivatives |
-
2011
- 2011-12-07 SI SI201131367T patent/SI2649044T1/en unknown
- 2011-12-07 PT PT118022805T patent/PT2649044T/pt unknown
- 2011-12-07 HU HUE11802280A patent/HUE033692T2/en unknown
- 2011-12-07 CA CA2820413A patent/CA2820413C/en active Active
- 2011-12-07 EP EP11802280.5A patent/EP2649044B1/en active Active
- 2011-12-07 WO PCT/EP2011/006142 patent/WO2012076165A1/en active Application Filing
- 2011-12-07 PL PL11802280T patent/PL2649044T3/pl unknown
- 2011-12-07 US US13/313,902 patent/US8658827B2/en active Active
- 2011-12-07 AR ARP110104587A patent/AR084209A1/es not_active Application Discontinuation
- 2011-12-07 ES ES11802280.5T patent/ES2653715T3/es active Active
- 2011-12-07 CN CN2011800585236A patent/CN103339102A/zh active Pending
-
2013
- 2013-06-04 IL IL226721A patent/IL226721A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2649044A1 (en) | 2013-10-16 |
| CA2820413A1 (en) | 2012-06-14 |
| IL226721A (en) | 2016-04-21 |
| CA2820413C (en) | 2019-05-07 |
| SI2649044T1 (en) | 2018-01-31 |
| US20120149914A1 (en) | 2012-06-14 |
| HUE033692T2 (en) | 2017-12-28 |
| PT2649044T (pt) | 2017-12-07 |
| US8658827B2 (en) | 2014-02-25 |
| ES2653715T3 (es) | 2018-02-08 |
| WO2012076165A1 (en) | 2012-06-14 |
| CN103339102A (zh) | 2013-10-02 |
| EP2649044B1 (en) | 2017-09-20 |
| PL2649044T3 (pl) | 2018-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |