AR076979A1 - 2- aminooxazolinas como ligandos de taar1 - Google Patents
2- aminooxazolinas como ligandos de taar1Info
- Publication number
- AR076979A1 AR076979A1 ARP100101977A ARP100101977A AR076979A1 AR 076979 A1 AR076979 A1 AR 076979A1 AR P100101977 A ARP100101977 A AR P100101977A AR P100101977 A ARP100101977 A AR P100101977A AR 076979 A1 AR076979 A1 AR 076979A1
- Authority
- AR
- Argentina
- Prior art keywords
- disorders
- lower alkyl
- halogen
- disease
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de la formula 1, son activos en el receptor de TAARI, y así, por lo tanto, son apropiados para el tratamiento de la depresion, los trastornos de la ansiedad, el trastorno bipolar, el trastorno de hiperactividad del déficit de atencion, los trastornos relacionados con el estrés, los trastornos psicoticos, la esquizofrenia, las enfermedades neurologicas, la enfermedad de Parkinson, los trastornos neurodegenerativos, la enfermedad de Alzheimer, la epilepsia, la migrana, el abuso de substancias y los trastornos metabolicos, los trastornos del comer, la diabetes, las complicaciones diabéticas, la obesidad, la dislipemia, los trastornos del consumo y de la asimilacion de energía, los trastornos y el mal funcionamiento de la homeostasis de la temperatura corporal, trastornos del sueno y del ritmo circardiano, y trastornos cardiovasculares. Composiciones farmacéuticas. Reivindicacion 1: Un compuesto de la formula (1) en donde, R1, es halogeno; R2, es alquilo inferior o alquilo inferior sustituido por halogeno; R2', es hidrogeno, alquilo inferior o alquilo inferior sustituido por halogeno; X, es un eslabon, -CH2-, -CH2CH2- o -CH2CH2CH2-; Y, es fenilo o ciclohexilo; y n, es 0, 1 o 2, o una sal de adicion de ácidos de éste, farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09162061 | 2009-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076979A1 true AR076979A1 (es) | 2011-07-20 |
Family
ID=42342699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101977A AR076979A1 (es) | 2009-06-05 | 2010-06-04 | 2- aminooxazolinas como ligandos de taar1 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100311798A1 (es) |
| AR (1) | AR076979A1 (es) |
| TW (1) | TW201103538A (es) |
| WO (1) | WO2010139707A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX377836B (es) | 2016-03-17 | 2025-03-11 | F Hoffmann La Roche Ag | Derivado de 5-etil-4-metil-pirazol-3-carboxamida teniendo actividad como agonista de receptor asociado con aminas trazas (taar). |
| EP3452473A1 (en) | 2016-05-04 | 2019-03-13 | Purdue Pharma L.P. | Oxazoline pseudodimers, pharmaceutical compositions and the use thereof |
| PL240819B1 (pl) * | 2020-06-25 | 2022-06-06 | Inst Biologii Doswiadczalnej Im M Nenckiego Polskiej Akademii Nauk | Pochodne 4,5-dihydro oksazol-2-ilo aminy do zastosowania w zapobieganiu lub leczeniu choroby alkoholowej |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2731471A (en) * | 1956-01-17 | Nxg hi | ||
| US2161938A (en) * | 1934-07-31 | 1939-06-13 | Soc Of Chemical Ind | Imidazolines |
| US2457047A (en) * | 1946-02-13 | 1948-12-21 | Monsanto Chemicals | 2-(2'-thenyl)-4, 5-dihydroimidazoles and process for making the same |
| US2778836A (en) * | 1954-04-02 | 1957-01-22 | Union Chimique Belge Sa | Substituted 2-methyl-delta2 imidazolines |
| US2744909A (en) * | 1955-06-27 | 1956-05-08 | Bristol Lab Inc | 2-(ortho-phenylbenzyl) imidazoline and acid addition salts |
| US2744910A (en) * | 1955-06-27 | 1956-05-08 | Bristol Lab Inc | 2-(ortho-benzylbenzyl)-imidazoline and acid addition salts |
| US2919274A (en) * | 1957-09-17 | 1959-12-29 | Sahyun Melville | Amidines |
| DE1121054B (de) * | 1960-11-23 | 1962-01-04 | Merck Ag E | Verfahren zur Herstellung eines neuen Imidazolinderivates und dessen Saeureadditionssalzen |
| DE1150180B (de) * | 1962-04-12 | 1963-06-12 | Merck Ag E | Mittel zur Vorbehandlung der Haut fuer die Rasur |
| US3377247A (en) * | 1967-04-28 | 1968-04-09 | Dow Chemical Co | Antidepressant method |
| US3586695A (en) * | 1968-01-26 | 1971-06-22 | Dow Chemical Co | Substituted imidazolinyl indoles |
| US3577428A (en) * | 1969-04-14 | 1971-05-04 | Colgate Palmolive Co | 2-amino-4-aryloxyalkyl-4-alkyl-2-oxazolines |
| BE754820R (fr) * | 1969-08-13 | 1971-02-15 | Schering Ag | Nouveaux derives de pyrimidine, leurs procedes de preparation et leurs |
| US3818094A (en) * | 1969-08-28 | 1974-06-18 | Boehringer Sohn Ingelheim | Hypotensive pharmaceutical compositions containing certain 2-anilino-1,3-diazacyclopentenes-(2) |
| US3660423A (en) * | 1970-02-13 | 1972-05-02 | Dow Chemical Co | 2-(substituted benzyl)methyl-2-imidazolines |
| US3688579A (en) * | 1970-06-08 | 1972-09-05 | Ralph L Fenner | Xeric element and method of preparing the same |
| GB1333471A (en) * | 1971-01-27 | 1973-10-10 | Labaz | Imidazoline derivatives and process for preparing the same |
| US4125620A (en) * | 1974-10-01 | 1978-11-14 | Boehringer Ingelheim Gmbh | 2-[(2',6'-Disubstituted-phenyl)-imino]-imidazolidines and salts thereof |
| US3992403A (en) * | 1975-05-30 | 1976-11-16 | Schering Corporation | 2-Imidazolines and their use as hypoglycemic agents |
| GB1538097A (en) * | 1976-01-26 | 1979-01-10 | Lafon Labor | Substituted phenyl-amidines |
| US4323570A (en) * | 1978-11-15 | 1982-04-06 | Beiersdorf Aktiengesellschaft | Substituted aminopyrimidines |
| US4311840A (en) * | 1980-11-13 | 1982-01-19 | E. R. Squibb & Sons, Inc. | 2,3,6,7-Tetrahydro-2-thioxo-4H-oxazolo[3,2-a]-1,3,5 triazin-4-ones |
| US4665095A (en) * | 1985-12-11 | 1987-05-12 | Abbott Laboratories | Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion |
| GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
| DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| US5610174A (en) * | 1995-06-02 | 1997-03-11 | Synaptic Pharmaceutical Corporation | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence |
| US5866579A (en) * | 1997-04-11 | 1999-02-02 | Synaptic Pharmaceutical Corporation | Imidazole and imidazoline derivatives and uses thereof |
| CA2328973A1 (en) * | 1998-04-23 | 1999-10-28 | Akio Ojida | Naphthalene derivatives, their production and use |
| IL147921A0 (en) * | 2002-01-31 | 2002-08-14 | Abdulrazik Mohammad | A method for treating central nervous system disorders by ocular dosing |
| WO2008092785A1 (en) * | 2007-02-02 | 2008-08-07 | F. Hoffmann-La Roche Ag | Novel 2-aminooxazolines as taar1 ligands for cns disorders |
-
2010
- 2010-05-28 US US12/789,484 patent/US20100311798A1/en not_active Abandoned
- 2010-06-02 TW TW099117804A patent/TW201103538A/zh unknown
- 2010-06-02 WO PCT/EP2010/057669 patent/WO2010139707A1/en active Application Filing
- 2010-06-04 AR ARP100101977A patent/AR076979A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201103538A (en) | 2011-02-01 |
| WO2010139707A1 (en) | 2010-12-09 |
| US20100311798A1 (en) | 2010-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |