AR076041A1 - Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral - Google Patents
Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oralInfo
- Publication number
- AR076041A1 AR076041A1 ARP100101093A ARP100101093A AR076041A1 AR 076041 A1 AR076041 A1 AR 076041A1 AR P100101093 A ARP100101093 A AR P100101093A AR P100101093 A ARP100101093 A AR P100101093A AR 076041 A1 AR076041 A1 AR 076041A1
- Authority
- AR
- Argentina
- Prior art keywords
- biomarkers
- expression
- under
- regulates
- extent
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56955—Bacteria involved in periodontal diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicacion 1: Un método para identificar un compuesto util para el tratamiento de una enfermedad o condicion de la cavidad oral, caracterizado porque incluye: obtener una primera muestra gingival de un mamífero que sufra de una enfermedad o condicion de la cavidad oral; obtener una segunda muestra gingival de la cavidad oral del mencionado mamífero; poner en contacto la mencionada primera muestra con un compuesto de prueba; poner en contacto la mencionada segunda muestra con un control positivo, en donde el mencionado control positivo es un compuesto que se sabe que bajo-regula la expresion de uno o más biomarcadores; medir la extension hasta la que el mencionado compuesto de prueba bajo-regula la expresion de uno o más de los mencionados biomarcadores; medir la extension hasta la que el mencionado control positivo bajo-regula la expresion de uno o más de los mencionados biomarcadores; y comparar la extension hasta la que el mencionado compuesto de prueba bajo-regula la expresion de uno o más de los mencionados biomarcadores, con la extension hasta la que el mencionado control positivo bajo-regula la expresion de uno o más de los mencionados biomarcadores; en donde un compuesto de prueba que bajo-regula la expresion de uno o más de los mencionados biomarcadores en una extension igual o mayor que el mencionado control positivo, es un compuesto util para tratar una enfermedad o condicion de la cavidad oral.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16567409P | 2009-04-01 | 2009-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076041A1 true AR076041A1 (es) | 2011-05-11 |
Family
ID=42813186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101093A AR076041A1 (es) | 2009-04-01 | 2010-03-31 | Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8753820B2 (es) |
| EP (1) | EP2414837B1 (es) |
| JP (1) | JP5643288B2 (es) |
| CN (1) | CN102549432B (es) |
| AR (1) | AR076041A1 (es) |
| BR (1) | BRPI1013184A2 (es) |
| CA (1) | CA2753718C (es) |
| CO (1) | CO6430490A2 (es) |
| MX (1) | MX2011008439A (es) |
| MY (1) | MY179250A (es) |
| RU (1) | RU2523383C2 (es) |
| SG (1) | SG173461A1 (es) |
| TW (1) | TWI481870B (es) |
| WO (1) | WO2010115034A2 (es) |
| ZA (1) | ZA201106056B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI405565B (zh) * | 2009-04-01 | 2013-08-21 | Colgate Palmolive Co | 口腔用組成物之抗－骨質流失及抗－牙周附連喪失之功效 |
| US9949671B2 (en) | 2013-03-13 | 2018-04-24 | Orthoaccel Technologies, Inc. | Diagnostic mouthpieces |
| WO2018129043A1 (en) * | 2017-01-03 | 2018-07-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for predicting risk of preterm birth |
| EP3631457A1 (en) | 2017-05-24 | 2020-04-08 | Koninklijke Philips N.V. | Diagnostics of mild or advanced periodontitis based on salivary il-1beta and mmp-9 |
| WO2018215630A1 (en) * | 2017-05-24 | 2018-11-29 | Koninklijke Philips N.V. | Diagnostics of periodontitis based on salivary hgf and mmp-8 |
| EP3631462A1 (en) * | 2017-05-24 | 2020-04-08 | Koninklijke Philips N.V. | Diagnostics of gingivitis based on salivary il-1beta and hgf |
| US11124833B2 (en) | 2017-10-27 | 2021-09-21 | Colgate-Palmolive Company | Salivary extracellular RNA biomarkers for gingivitis |
| EP3477306A1 (en) * | 2017-10-30 | 2019-05-01 | Koninklijke Philips N.V. | Classification of periodontitis patients |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US4358437A (en) | 1978-11-29 | 1982-11-09 | Beecham Group Limited | Compositions |
| US5288480A (en) | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
| GB9117140D0 (en) | 1991-08-08 | 1991-09-25 | Unilever Plc | Treatment of periodontitis |
| DE4226043A1 (de) | 1992-08-06 | 1994-02-10 | Haarmann & Reimer Gmbh | Mittel mit physiologischem Kühleffekt und für diese Mittel geeignete wirksame Verbindungen |
| CA2176237A1 (en) | 1993-11-10 | 1995-05-18 | Richard P. Darveau | Treatment of bacterially-induced inflammatory diseases |
| US5578295A (en) | 1995-04-28 | 1996-11-26 | The Procter & Gamble Company | Oral care compositions comprising certain substituted diphenyl ethers |
| AU3171997A (en) | 1996-06-12 | 1998-01-07 | Henkel Kommanditgesellschaft Auf Aktien | Cosmetic and/or pharmaceutical preparations |
| FR2794457B1 (fr) | 1999-06-01 | 2001-08-10 | Oreal | Derives carbonates de retinol, procede de preparation et utilisations |
| ES2395991T3 (es) | 1999-12-03 | 2013-02-18 | Baxter International Inc. | Ensayo de pirogenicidad para su uso con sistemas de inmunoensayo automáticos |
| GB0001704D0 (en) | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| JP2003530130A (ja) | 2000-04-14 | 2003-10-14 | メタボロン インコーポレイテッド | メタボロミクスを使用した薬物発見、疾患の処置、及び診断のための方法 |
| US6500409B1 (en) | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| DE10059584A1 (de) | 2000-11-30 | 2002-06-06 | Beiersdorf Ag | Kosmetische oder dermatologische getränkte Tücher |
| US7005225B2 (en) | 2002-11-12 | 2006-02-28 | Samsung Electronics Company | Organosol including amphipathic copolymeric binder having crystalline material, and use of the organosol to make dry tones for electrographic applications |
| WO2004073614A2 (en) | 2003-02-14 | 2004-09-02 | Combinatorx, Incorporated | Combination therapy for the treatment of immunoinflammatory disorders |
| GB2401865A (en) | 2003-05-22 | 2004-11-24 | Givaudan Sa | Antibacterial and antifungal glycerol monocarbonates |
| EP1697389A4 (en) | 2003-10-24 | 2008-12-24 | Eisai R&D Man Co Ltd | COMPOUNDS AND METHODS FOR TREATING ILLNESS AND SUFFERING TOLL-LIKE RECEPTOR 2 RELATED DISORDERS |
| ATE422506T1 (de) | 2003-12-03 | 2009-02-15 | Whitehead Biomedical Inst | Verwendung von löslichem t-cadherin zur behandlung von stoffwechselkrankheiten |
| FI20040572A0 (fi) | 2004-04-23 | 2004-04-23 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasin aktiviteetin inhibiittorit |
| US20050271601A1 (en) * | 2004-06-02 | 2005-12-08 | Nebojsa Milanovich | Anti-staining antibacterial dentifrice |
| JP4934812B2 (ja) * | 2004-12-21 | 2012-05-23 | 国立大学法人 奈良先端科学技術大学院大学 | Ｎｆａｔ２発現抑制方法 |
| US20060141421A1 (en) | 2004-12-28 | 2006-06-29 | Kimberly-Clark Worldwide, Inc. | System and method for detecting substances related to oral health |
| WO2006074450A2 (en) | 2005-01-07 | 2006-07-13 | President And Fellows Of Harvard College | Methods and compositions for detecting and modulating periodontal disorders and periodontal diseases |
| CA2635605C (en) * | 2006-01-10 | 2014-07-08 | Colgate-Palmolive Company | Methods of modulating cell surface receptors to prevent or reduce inflammation |
| US20080161394A1 (en) | 2006-11-23 | 2008-07-03 | Jean-Yves Fouron | Cosmetic composition comprising at least one volatile carbonic acid ester |
| WO2008093072A2 (en) | 2007-01-29 | 2008-08-07 | Paul Webb | Topical composition against contact dermatitis due to water |
| EP2207546A1 (en) | 2007-10-09 | 2010-07-21 | Humco Holding Group, Inc. | Antifungal treatment of nails |
-
2010
- 2010-03-31 AR ARP100101093A patent/AR076041A1/es unknown
- 2010-03-31 TW TW099109774A patent/TWI481870B/zh not_active IP Right Cessation
- 2010-04-01 US US13/262,038 patent/US8753820B2/en active Active
- 2010-04-01 RU RU2011144032/15A patent/RU2523383C2/ru not_active IP Right Cessation
- 2010-04-01 EP EP10712275.6A patent/EP2414837B1/en not_active Not-in-force
- 2010-04-01 BR BRPI1013184A patent/BRPI1013184A2/pt not_active IP Right Cessation
- 2010-04-01 WO PCT/US2010/029674 patent/WO2010115034A2/en active Application Filing
- 2010-04-01 MY MYPI2011003578A patent/MY179250A/en unknown
- 2010-04-01 JP JP2012503717A patent/JP5643288B2/ja not_active Expired - Fee Related
- 2010-04-01 MX MX2011008439A patent/MX2011008439A/es active IP Right Grant
- 2010-04-01 CN CN201080015874.4A patent/CN102549432B/zh not_active Expired - Fee Related
- 2010-04-01 SG SG2011054509A patent/SG173461A1/en unknown
- 2010-04-01 CA CA2753718A patent/CA2753718C/en not_active Expired - Fee Related
-
2011
- 2011-08-17 ZA ZA2011/06056A patent/ZA201106056B/en unknown
- 2011-09-27 CO CO11126599A patent/CO6430490A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US20120028261A1 (en) | 2012-02-02 |
| CA2753718A1 (en) | 2010-10-07 |
| TW201102653A (en) | 2011-01-16 |
| WO2010115034A2 (en) | 2010-10-07 |
| CN102549432A (zh) | 2012-07-04 |
| MX2011008439A (es) | 2011-09-06 |
| CA2753718C (en) | 2015-06-23 |
| EP2414837A2 (en) | 2012-02-08 |
| CO6430490A2 (es) | 2012-04-30 |
| ZA201106056B (en) | 2015-05-27 |
| EP2414837B1 (en) | 2015-06-03 |
| SG173461A1 (en) | 2011-09-29 |
| AU2010232593A1 (en) | 2011-08-25 |
| MY179250A (en) | 2020-11-02 |
| RU2011144032A (ru) | 2013-05-10 |
| TWI481870B (zh) | 2015-04-21 |
| BRPI1013184A2 (pt) | 2016-04-12 |
| JP2012522994A (ja) | 2012-09-27 |
| CN102549432B (zh) | 2015-03-25 |
| JP5643288B2 (ja) | 2014-12-17 |
| RU2523383C2 (ru) | 2014-07-20 |
| WO2010115034A3 (en) | 2010-12-29 |
| US8753820B2 (en) | 2014-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |