AR074924A2 - Peptidos y derivados tipo peptido ligando alterado (apl) de la hsp60 y composiciones farmaceuticas - Google Patents
Peptidos y derivados tipo peptido ligando alterado (apl) de la hsp60 y composiciones farmaceuticasInfo
- Publication number
- AR074924A2 AR074924A2 ARP090105137A ARP090105137A AR074924A2 AR 074924 A2 AR074924 A2 AR 074924A2 AR P090105137 A ARP090105137 A AR P090105137A AR P090105137 A ARP090105137 A AR P090105137A AR 074924 A2 AR074924 A2 AR 074924A2
- Authority
- AR
- Argentina
- Prior art keywords
- peptides
- pharmaceutical compositions
- hsp60
- apl
- binding peptide
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 102000006303 Chaperonin 60 Human genes 0.000 title 1
- 108010058432 Chaperonin 60 Proteins 0.000 title 1
- 230000007246 mechanism Effects 0.000 abstract 2
- 206010011968 Decreased immune responsiveness Diseases 0.000 abstract 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000008646 thermal stress Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La solicitud también refiere a composiciones farmacéuticas que comprenden tales péptidos para tratamiento de la artritis reumatoide. Reivindicación 1: Un péptido de la proteína humana de estrés térmico de 60 kDa que constituye epítope para células T, para inducir mecanismos de tolerancia periférica, en particular mecanismos inductores de anergia o mediados por clones de células T regulatorias en pacientes con AR caracterizado porque presenta la secuencia E18-12 MGPKGRTVIIEQSWGSPKVTK (SEQ. ID. Ns:1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20040207A CU23504A1 (es) | 2004-09-24 | 2004-09-24 | Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074924A2 true AR074924A2 (es) | 2011-02-23 |
Family
ID=40273413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103950A AR051928A1 (es) | 2004-09-24 | 2005-09-21 | Peptidos y derivados tipo apl de la hsp60 y composiciones farmaceuticas |
| ARP090105137A AR074924A2 (es) | 2004-09-24 | 2009-12-28 | Peptidos y derivados tipo peptido ligando alterado (apl) de la hsp60 y composiciones farmaceuticas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103950A AR051928A1 (es) | 2004-09-24 | 2005-09-21 | Peptidos y derivados tipo apl de la hsp60 y composiciones farmaceuticas |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8383771B2 (es) |
| EP (2) | EP1803732B1 (es) |
| JP (1) | JP4755649B2 (es) |
| KR (2) | KR101035283B1 (es) |
| CN (2) | CN101065398B (es) |
| AR (2) | AR051928A1 (es) |
| AT (1) | ATE546462T1 (es) |
| AU (2) | AU2005287757B2 (es) |
| BR (2) | BR122018077204B8 (es) |
| CA (2) | CA2797769C (es) |
| CU (1) | CU23504A1 (es) |
| DK (2) | DK1803732T3 (es) |
| ES (2) | ES2445707T3 (es) |
| MX (1) | MX2007003624A (es) |
| RU (1) | RU2361877C2 (es) |
| WO (1) | WO2006032216A2 (es) |
| ZA (1) | ZA200702938B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009008230A (es) | 2007-01-30 | 2010-03-08 | Epivax Inc | Epitopes de celulas t reguladoras, composiciones y usos para los mismos. |
| CU23701A1 (es) * | 2008-12-29 | 2011-09-21 | Ct Ingenieria Genetica Biotech | Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
| CN102740877B (zh) * | 2009-09-06 | 2015-01-14 | 普罗塔布有限公司 | 对源自hsp65的肽-6有特异性的人源化抗体及其方法和用途 |
| WO2011059758A2 (en) * | 2009-10-28 | 2011-05-19 | Argentis Pharmaceuticals, Llc | Apls for treating arthritis |
| CU24508B1 (es) * | 2017-12-29 | 2021-04-07 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición farmacéutica que comprende péptido tipo apl |
| CU20200026A7 (es) * | 2020-04-13 | 2021-11-04 | Ct Ingenieria Genetica Biotecnologia | Péptido para el tratamiento del síndrome de la tormenta de citocinas |
| CN111870697B (zh) * | 2020-09-18 | 2022-09-09 | 山东鲁抗医药股份有限公司 | 糖类物质在提高apl型衍生肽稳定性中的应用和冻干组合物 |
| KR102333645B1 (ko) | 2021-07-27 | 2021-12-02 | (주)문화전기 | 각도조절이 용이한 엘이디조명시스템 |
| CN115671253B (zh) * | 2021-07-30 | 2024-02-27 | 河北菲尼斯生物技术有限公司 | Se-dr亲和肽在制备治疗风湿疾病的药物中的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8701163A (nl) | 1986-09-09 | 1988-04-05 | Nederlanden Staat | Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits. |
| NL8703107A (nl) | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
| US5773570A (en) | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
| GB9419553D0 (en) | 1994-09-27 | 1994-11-16 | Univ Bristol | Polypeptides and their use in the treatment of auto-immune disease |
| US6180103B1 (en) | 1994-12-21 | 2001-01-30 | Yeda Research And Development Co., Ltd. | Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes |
| GB9519737D0 (en) * | 1995-09-27 | 1995-11-29 | Peptide Therapeutics Ltd | Polypeptides and their use in treatment and prophylaxis of auto-immune |
| US5993803A (en) | 1996-08-30 | 1999-11-30 | Yeda Research And Development Co., Ltd. | Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity |
| GB9911772D0 (en) | 1999-05-21 | 1999-07-21 | Semmelweis University Of Medic | Diagnosis and treatment of atherosclerosis |
| US20020169302A1 (en) * | 1999-08-23 | 2002-11-14 | Genesis Research And Development Corp. Ltd. | Compositions isolated from bovine mammary gland and methods for their use |
| NZ519348A (en) * | 1999-12-15 | 2006-04-28 | Develogen Israel Ltd | Fragments and antagonists of heat shock protein 60 |
| US7534419B2 (en) | 2001-01-19 | 2009-05-19 | Depuy Mitek, Inc. | Methods of diagnosis and treatment of osteoporosis |
-
2004
- 2004-09-24 CU CU20040207A patent/CU23504A1/es active IP Right Grant
-
2005
- 2005-09-21 AR ARP050103950A patent/AR051928A1/es active IP Right Grant
- 2005-09-22 KR KR1020107001135A patent/KR101035283B1/ko active IP Right Grant
- 2005-09-22 ES ES10189769.2T patent/ES2445707T3/es active Active
- 2005-09-22 JP JP2007532752A patent/JP4755649B2/ja active Active
- 2005-09-22 EP EP05794474A patent/EP1803732B1/en active Active
- 2005-09-22 RU RU2007115411/04A patent/RU2361877C2/ru active
- 2005-09-22 BR BR122018077204A patent/BR122018077204B8/pt active IP Right Grant
- 2005-09-22 MX MX2007003624A patent/MX2007003624A/es active IP Right Grant
- 2005-09-22 DK DK05794474.6T patent/DK1803732T3/da active
- 2005-09-22 AU AU2005287757A patent/AU2005287757B2/en not_active Ceased
- 2005-09-22 CN CN2005800403891A patent/CN101065398B/zh active Active
- 2005-09-22 CA CA2797769A patent/CA2797769C/en active Active
- 2005-09-22 CA CA2581110A patent/CA2581110C/en active Active
- 2005-09-22 CN CN2010100038161A patent/CN101935345B/zh active Active
- 2005-09-22 US US11/663,603 patent/US8383771B2/en active Active
- 2005-09-22 EP EP10189769.2A patent/EP2371847B1/en active Active
- 2005-09-22 KR KR1020077008682A patent/KR101054332B1/ko active IP Right Grant
- 2005-09-22 DK DK10189769.2T patent/DK2371847T3/da active
- 2005-09-22 WO PCT/CU2005/000008 patent/WO2006032216A2/es active Application Filing
- 2005-09-22 BR BRPI0515893A patent/BRPI0515893B8/pt active IP Right Grant
- 2005-09-22 ES ES05794474T patent/ES2386498T3/es active Active
- 2005-09-22 AT AT05794474T patent/ATE546462T1/de active
-
2007
- 2007-04-10 ZA ZA200702938A patent/ZA200702938B/xx unknown
-
2009
- 2009-12-28 AR ARP090105137A patent/AR074924A2/es active IP Right Grant
- 2009-12-30 US US12/649,687 patent/US8324164B2/en active Active
-
2010
- 2010-09-06 AU AU2010219312A patent/AU2010219312B2/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |