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AR074876A1 - Derivados de indol-pirimidina para tratar cancer - Google Patents

Derivados de indol-pirimidina para tratar cancer

Info

Publication number
AR074876A1
AR074876A1 ARP090105074A ARP090105074A AR074876A1 AR 074876 A1 AR074876 A1 AR 074876A1 AR P090105074 A ARP090105074 A AR P090105074A AR P090105074 A ARP090105074 A AR P090105074A AR 074876 A1 AR074876 A1 AR 074876A1
Authority
AR
Argentina
Prior art keywords
methyl
hydrogen
indol
treat cancer
pyrimidine derivatives
Prior art date
Application number
ARP090105074A
Other languages
English (en)
Inventor
Kevin Michael Foote
Johannes Wilhelmus Maria Nissink
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR074876A1 publication Critical patent/AR074876A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia de tumores. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1): en donde: el Anillo A es un cicloalquiloC3-6 o un anillo heterocíclico de 4-6 miembros saturado que contiene un heteroátomo que se selecciona de O, N y S; R1 se selecciona de morfolin-4-ilo, 3-metilmorfolin-4-ilo, 3,5-dimetilmorfolin-4-iIo y un grupo 8-oxa-3-azabicicIo[3,2,1]octan-3-ilo; R2 y R5 son hidrógeno; R3 es hidrógeno o metilo; R4 se selecciona de hidrógeno, metilo, fluoro, cloro, ciano y metoxi; R6 es un grupo que se selecciona de metilo, etilo, i-propilo y ciclopropilo; o una sal farmacéuticamente aceptable del mismo.
ARP090105074A 2008-12-22 2009-12-22 Derivados de indol-pirimidina para tratar cancer AR074876A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13968108P 2008-12-22 2008-12-22

Publications (1)

Publication Number Publication Date
AR074876A1 true AR074876A1 (es) 2011-02-16

Family

ID=41682867

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090105074A AR074876A1 (es) 2008-12-22 2009-12-22 Derivados de indol-pirimidina para tratar cancer

Country Status (25)

Country Link
US (1) US20110053923A1 (es)
EP (1) EP2379530A1 (es)
JP (1) JP2012513388A (es)
KR (1) KR20110094342A (es)
CN (1) CN102325764A (es)
AR (1) AR074876A1 (es)
AU (1) AU2009332745A1 (es)
BR (1) BRPI0922475A2 (es)
CA (1) CA2750841A1 (es)
CL (1) CL2011001536A1 (es)
CO (1) CO6390107A2 (es)
CR (1) CR20110349A (es)
CU (1) CU20110137A7 (es)
DO (1) DOP2011000203A (es)
EA (1) EA201100971A1 (es)
EC (1) ECSP11011156A (es)
IL (1) IL213470A0 (es)
MX (1) MX2011006754A (es)
NI (1) NI201100130A (es)
PE (1) PE20110894A1 (es)
SG (1) SG171975A1 (es)
TW (1) TW201028410A (es)
UY (1) UY32351A (es)
WO (1) WO2010073034A1 (es)
ZA (1) ZA201105395B (es)

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PT2376485T (pt) 2008-12-19 2018-03-12 Vertex Pharma Derivados de pirazina úteis como inibidores da cinase atr
RU2012153675A (ru) 2010-05-12 2014-06-20 Вертекс Фармасьютикалз Инкорпорейтед Соединения, пригодные в качестве ингибиторов atr киназы
EP2569287B1 (en) 2010-05-12 2014-07-09 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
SA111320519B1 (ar) * 2010-06-11 2014-07-02 Astrazeneca Ab مركبات بيريميدينيل للاستخدام كمثبطات atr
EP2751097A2 (en) 2011-09-30 2014-07-09 Vertex Pharmaceuticals Incorporated Processes for making compounds useful as inhibitors of atr kinase
CN108685922A (zh) 2011-09-30 2018-10-23 沃泰克斯药物股份有限公司 用atr抑制剂治疗胰腺癌和非小细胞肺癌
PL2833973T3 (pl) 2012-04-05 2018-02-28 Vertex Pharmaceuticals Incorporated Związki użyteczne jako inhibitory kinazy ATR i ich terapie skojarzone
EP2904406B1 (en) 2012-10-04 2018-03-21 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
CA2950780C (en) 2014-06-17 2023-05-16 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of chk1 and atr inhibitors
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RU2701188C2 (ru) * 2015-02-27 2019-09-25 Нэнтбайосайенс, Инк. Производные пиримидина в качестве ингибиторов киназы и их терапевтические применения
EP3355926A4 (en) 2015-09-30 2019-08-21 Vertex Pharmaceuticals Inc. METHOD FOR THE TREATMENT OF CANCER WITH A COMBINATION OF DNA DAMAGING AGENTS AND ATR INHIBITORS
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WO2018153972A1 (en) 2017-02-24 2018-08-30 Bayer Pharma Aktiengesellschaft Combination of atr kinase inhibitors and antiandrogens
JOP20190197A1 (ar) 2017-02-24 2019-08-22 Bayer Pharma AG مثبط كيناز ايه تي آر للاستخدام في طريقة لعلاج مرض فرط التكاثر
UY37616A (es) 2017-02-24 2018-09-28 Bayer Ag Combinación de inhibidores de quinasa atr con sal de radio-223
EP3585365B1 (en) 2017-02-24 2021-08-25 Bayer Pharma Aktiengesellschaft Combination of atr kinase inhibitors with parp inhibitors
WO2018206547A1 (en) 2017-05-12 2018-11-15 Bayer Pharma Aktiengesellschaft Combination of bub1 and atr inhibitors
US10421765B2 (en) 2017-05-26 2019-09-24 Board Of Regents, The University Of Texas System Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
DK3651768T3 (da) 2017-07-13 2024-03-18 Univ Texas Heterocykliske inhibitorer af atr-kinase
WO2019025440A1 (en) 2017-08-04 2019-02-07 Bayer Pharma Aktiengesellschaft COMBINATION OF ATR KINASE INHIBITORS AND PD-1 / PD-L1 INHIBITORS
EP3668839B1 (en) * 2017-08-17 2023-04-12 Board of Regents, The University of Texas System Heterocyclic inhibitors of atr kinase
CA3084863A1 (en) 2017-12-08 2019-06-13 Bayer Aktiengesellschaft Predictive markers for atr kinase inhibitors
SG11202007485PA (en) * 2018-02-07 2020-09-29 Shijiazhuang Sagacity New Drug Development Company Ltd Atr inhibitor and application thereof
US10894052B2 (en) 2018-03-16 2021-01-19 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of ATR kinase
DK3846904T3 (da) * 2018-09-07 2023-08-21 Merck Patent Gmbh 5-morpholin-4-yl-pyrazolo[4,3-b]pyridinderivater
EP3866805A1 (en) 2018-10-16 2021-08-25 Bayer Aktiengesellschaft Combination of atr kinase inhibitors with 2,3-dihydroimidazo[1,2-c]quinazoline compounds
CN111606889B (zh) * 2019-02-25 2023-03-07 上海翰森生物医药科技有限公司 4-(1-环丙基-1h-吲哚-3-基)-n-苯基嘧啶-2-胺衍生物的制备方法
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Also Published As

Publication number Publication date
AU2009332745A1 (en) 2011-06-30
BRPI0922475A2 (pt) 2017-06-06
CL2011001536A1 (es) 2011-10-14
CN102325764A (zh) 2012-01-18
MX2011006754A (es) 2011-07-20
CA2750841A1 (en) 2010-07-01
IL213470A0 (en) 2011-07-31
EP2379530A1 (en) 2011-10-26
CO6390107A2 (es) 2012-02-29
TW201028410A (en) 2010-08-01
CR20110349A (es) 2011-08-05
NI201100130A (es) 2012-03-19
CU20110137A7 (es) 2012-01-31
EA201100971A1 (ru) 2012-01-30
PE20110894A1 (es) 2012-01-18
JP2012513388A (ja) 2012-06-14
KR20110094342A (ko) 2011-08-23
ECSP11011156A (es) 2011-07-29
SG171975A1 (en) 2011-07-28
UY32351A (es) 2010-07-30
DOP2011000203A (es) 2011-07-15
WO2010073034A1 (en) 2010-07-01
US20110053923A1 (en) 2011-03-03
ZA201105395B (en) 2012-03-28

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