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AR073983A1 - Uso de 7- cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino (4,5-b) indol-1-acetamida como biomarcador de los niveles del receptor periferico de benzodiazepinas - Google Patents

Uso de 7- cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino (4,5-b) indol-1-acetamida como biomarcador de los niveles del receptor periferico de benzodiazepinas

Info

Publication number
AR073983A1
AR073983A1 ARP090104122A ARP090104122A AR073983A1 AR 073983 A1 AR073983 A1 AR 073983A1 AR P090104122 A ARP090104122 A AR P090104122A AR P090104122 A ARP090104122 A AR P090104122A AR 073983 A1 AR073983 A1 AR 073983A1
Authority
AR
Argentina
Prior art keywords
pyridazino
acetamide
dihydro
trimethyl
oxo
Prior art date
Application number
ARP090104122A
Other languages
English (en)
Inventor
Jesus Benavides
Marie-Noelle Castel
Frank Marguet
Herve Boutin
Annelaure Damont
Frederic Dolle
Philippe Hantraye
Thomas Rooney
Luc Rivron
Bertrand Tavitian
Cyrille Thominiaux
Original Assignee
Commissariat Energie Atomique
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Sanofi Aventis filed Critical Commissariat Energie Atomique
Publication of AR073983A1 publication Critical patent/AR073983A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Uso de una forma radiomarcada de 7-cloro-N,N,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4H-piridazino[4,5-b]indol-1-acetamida radiomarcada como biomarcador para la deteccion, en un individuo, de los niveles de PBR asociados con estados normales y patologicos, en el que la radio-marca se elige entre carbono-11, radio- halogenos y radio-metales. Método para la deteccion de los niveles de PBR asociados con estados normales y patologicos. Kit de diagnostico.
ARP090104122A 2008-10-28 2009-10-27 Uso de 7- cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino (4,5-b) indol-1-acetamida como biomarcador de los niveles del receptor periferico de benzodiazepinas AR073983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08291013A EP2181717A1 (en) 2008-10-28 2008-10-28 Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Publications (1)

Publication Number Publication Date
AR073983A1 true AR073983A1 (es) 2010-12-15

Family

ID=40262247

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104122A AR073983A1 (es) 2008-10-28 2009-10-27 Uso de 7- cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino (4,5-b) indol-1-acetamida como biomarcador de los niveles del receptor periferico de benzodiazepinas

Country Status (32)

Country Link
US (2) US20120039816A1 (es)
EP (2) EP2181717A1 (es)
JP (1) JP5743894B2 (es)
KR (2) KR20110098711A (es)
CN (1) CN102223899B (es)
AR (1) AR073983A1 (es)
AU (1) AU2009309339C1 (es)
BR (1) BRPI0920412A2 (es)
CA (1) CA2741620C (es)
CL (2) CL2011000954A1 (es)
CO (1) CO6382141A2 (es)
CY (1) CY1115211T1 (es)
DK (1) DK2349352T3 (es)
EA (1) EA020612B1 (es)
ES (1) ES2452665T3 (es)
HK (1) HK1161686A1 (es)
HR (1) HRP20140250T1 (es)
IL (1) IL212473A (es)
MA (1) MA32803B1 (es)
ME (2) ME01819B (es)
MX (1) MX2011004420A (es)
MY (1) MY152968A (es)
NZ (1) NZ592479A (es)
PL (1) PL2349352T3 (es)
PT (1) PT2349352E (es)
RS (1) RS53273B (es)
SI (1) SI2349352T1 (es)
SM (1) SMT201400070B (es)
TW (1) TWI450728B (es)
UY (1) UY32206A (es)
WO (1) WO2010049819A1 (es)
ZA (1) ZA201103082B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201016038D0 (en) * 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
EP4278367A1 (en) * 2021-01-15 2023-11-22 Minnetronix Neuro, Inc. Systems and methods for managing, monitoring, and treating patient conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
JP4362457B2 (ja) * 2005-04-26 2009-11-11 独立行政法人科学技術振興機構 神経因性疼痛治療剤
BRPI0716583A2 (pt) * 2006-08-24 2013-10-01 Australian Nuclear Science Tec ligandos fluorados para marcar recptores de benzodiazepina perifÉricos
CA2680762A1 (en) * 2007-03-12 2008-09-25 National Institute Of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
EP1997515A1 (en) * 2007-05-30 2008-12-03 Bayer Schering Pharma Aktiengesellschaft Use of radiolabelled phenyloxyaniline derivatives for imaging diseases associated with peripheral benzodiazepin receptor's activation

Also Published As

Publication number Publication date
IL212473A0 (en) 2011-06-30
KR20110098711A (ko) 2011-09-01
AU2009309339C1 (en) 2016-01-14
RS53273B (en) 2014-08-29
BRPI0920412A2 (pt) 2015-12-22
SI2349352T1 (sl) 2014-07-31
MX2011004420A (es) 2011-11-18
US20170160287A1 (en) 2017-06-08
EP2181717A1 (en) 2010-05-05
NZ592479A (en) 2013-03-28
TW201029671A (en) 2010-08-16
ME01128B (me) 2013-03-20
CN102223899A (zh) 2011-10-19
EA020612B1 (ru) 2014-12-30
IL212473A (en) 2015-01-29
CA2741620C (en) 2016-08-16
CN102223899B (zh) 2014-08-27
AU2009309339A1 (en) 2010-05-06
UY32206A (es) 2010-05-31
CL2013001041A1 (es) 2014-01-24
EA201170613A1 (ru) 2011-12-30
CO6382141A2 (es) 2012-02-15
EP2349352A1 (en) 2011-08-03
AU2009309339B2 (en) 2015-08-27
ES2452665T3 (es) 2014-04-02
WO2010049819A8 (en) 2011-05-26
US20120039816A1 (en) 2012-02-16
KR20160070846A (ko) 2016-06-20
DK2349352T3 (da) 2014-03-31
EP2349352B1 (en) 2013-12-25
MY152968A (en) 2014-12-15
ZA201103082B (en) 2013-01-30
WO2010049819A1 (en) 2010-05-06
JP2012507031A (ja) 2012-03-22
JP5743894B2 (ja) 2015-07-01
SMT201400070B (it) 2014-07-07
CL2011000954A1 (es) 2012-01-20
PL2349352T3 (pl) 2014-05-30
MA32803B1 (fr) 2011-11-01
HK1161686A1 (en) 2012-08-03
PT2349352E (pt) 2014-04-03
CY1115211T1 (el) 2017-01-04
ME01819B (me) 2014-09-20
TWI450728B (zh) 2014-09-01
CA2741620A1 (en) 2010-05-06
HRP20140250T1 (hr) 2014-06-20

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