AR073408A2 - POLYMERIC CONJUGATES OF CYTOKINES, CHEMIOCINES, GROWTH FACTORS, POLYPEPTIDIC HORMONES AND ITS ANTAGONISTS WITH CONSERVED ACTIVITY OF UNION TO THE RECEIVER - Google Patents
POLYMERIC CONJUGATES OF CYTOKINES, CHEMIOCINES, GROWTH FACTORS, POLYPEPTIDIC HORMONES AND ITS ANTAGONISTS WITH CONSERVED ACTIVITY OF UNION TO THE RECEIVERInfo
- Publication number
- AR073408A2 AR073408A2 ARP090103741A AR073408A2 AR 073408 A2 AR073408 A2 AR 073408A2 AR P090103741 A ARP090103741 A AR P090103741A AR 073408 A2 AR073408 A2 AR 073408A2
- Authority
- AR
- Argentina
- Prior art keywords
- conjugates
- cytokines
- growth factors
- methods
- hormones
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Se suministran métodos para la síntesis de conjugados poliméricos de citoquinas, quimiocinas, factores de crecimiento, hormonas polipeptídicas y sus antagonistas de union al receptor, conjugados que retienen actividad de union al receptor inusualmente elevada. La preparacion de conjugados poliméricos de acuerdo con dichos métodos reduce o evita la inhibicion estérica de interacciones receptor-ligando que comunmente se producen a partir de la union de polímeros a las regiones de union al receptor de las citoquinas, quimiocinas, factores de crecimiento y hormonas polipeptídicas, como así también a sus análogos agonistas y antagonistas. Se suministra además, los conjugados y las composiciones producidos por tales métodos. Los conjugados retienen un nivel de actividad de union al receptor más alto que el producido por los métodos tradicionales de acoplamiento de polímeros que no se han orientado para evitar los dominios de union al receptor de citoquinas, quimiocinas, factores de crecimiento y hormonas polipeptídicas. Los conjugados exhiben, además, una vida media extendida in vivo e in vitro si se compara con las citoquinas, quimiocinas, factores de crecimiento y hormonas polipeptídicas no conjugados. Además, kits que comprenden dichos conjugados y/o composiciones, y métodos de uso de tales conjugados y composiciones en una variedad de aplicaciones diagnosticas, profilácticas, terapéuticas y de procesamiento biologico.Methods for the synthesis of polymeric conjugates of cytokines, chemokines, growth factors, polypeptide hormones and their receptor binding antagonists, conjugates that retain unusually high receptor binding activity are provided. The preparation of polymer conjugates according to said methods reduces or prevents steric inhibition of receptor-ligand interactions that commonly occur from the binding of polymers to the receptor binding regions of cytokines, chemokines, growth factors and hormones. polypeptide, as well as its agonist and antagonist analogs. Conjugates and compositions produced by such methods are also supplied. The conjugates retain a higher level of receptor binding activity than that produced by traditional polymer coupling methods that have not been targeted to avoid the receptor binding domains of cytokines, chemokines, growth factors and polypeptide hormones. The conjugates also exhibit an extended half-life in vivo and in vitro when compared to cytokines, chemokines, growth factors and unconjugated polypeptide hormones. In addition, kits comprising said conjugates and / or compositions, and methods of using such conjugates and compositions in a variety of diagnostic, prophylactic, therapeutic and biological processing applications.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47991403P | 2003-06-20 | 2003-06-20 | |
| US10/743,295 US20040136952A1 (en) | 2002-12-26 | 2003-12-23 | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073408A2 true AR073408A2 (en) | 2010-11-03 |
Family
ID=42778299
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102168 AR044857A1 (en) | 2003-06-20 | 2004-06-22 | POLYMERIC CONJUGATES OF CYTOKINES, CHEMIOCINES, GROWTH FACTORS, POLYPEPTIDIC HORMONES AND THEIR ANTAGONISTS WITH CONSERVED ACTIVITY OF UNION TO THE RECEIVER |
| ARP090103741 AR073408A2 (en) | 2003-06-20 | 2009-09-29 | POLYMERIC CONJUGATES OF CYTOKINES, CHEMIOCINES, GROWTH FACTORS, POLYPEPTIDIC HORMONES AND ITS ANTAGONISTS WITH CONSERVED ACTIVITY OF UNION TO THE RECEIVER |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102168 AR044857A1 (en) | 2003-06-20 | 2004-06-22 | POLYMERIC CONJUGATES OF CYTOKINES, CHEMIOCINES, GROWTH FACTORS, POLYPEPTIDIC HORMONES AND THEIR ANTAGONISTS WITH CONSERVED ACTIVITY OF UNION TO THE RECEIVER |
Country Status (1)
| Country | Link |
|---|---|
| AR (2) | AR044857A1 (en) |
-
2004
- 2004-06-22 AR ARP040102168 patent/AR044857A1/en not_active Application Discontinuation
-
2009
- 2009-09-29 AR ARP090103741 patent/AR073408A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR044857A1 (en) | 2005-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |