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AR072135A1 - Formas de dosificacion de fenofibrato - Google Patents

Formas de dosificacion de fenofibrato

Info

Publication number
AR072135A1
AR072135A1 ARP090101116A ARP090101116A AR072135A1 AR 072135 A1 AR072135 A1 AR 072135A1 AR P090101116 A ARP090101116 A AR P090101116A AR P090101116 A ARP090101116 A AR P090101116A AR 072135 A1 AR072135 A1 AR 072135A1
Authority
AR
Argentina
Prior art keywords
fenofibrate
particles
dosage forms
physiological conditions
dosage form
Prior art date
Application number
ARP090101116A
Other languages
English (en)
Inventor
Michael John Wilkins
Tuula Ryde
Evan E Gustow
Stephen B Ruddy
Rakesh Patel
Niels P Ryde
Rajeev Jain
Original Assignee
Fournier Lab Ireland Ltd
Elan Pharma Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Ireland Ltd, Elan Pharma Int Ltd filed Critical Fournier Lab Ireland Ltd
Publication of AR072135A1 publication Critical patent/AR072135A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Metodos in vitro para evaluar la efectividad in vivo de formas de dosis del fibrato, tal como fenofibrato. Los metodos utilizan medios representativos en condiciones fisiologicas humanas in vivo. Reivindicacion 1: Una forma de dosificacion de fenofibrato caracterizada porque comprende: part¡culas que consisten en fenofibrato; y al menos un estabilizador de superficie adsorbido en la superficie de las part¡culas, en donde despues de la reconstitucion en un medio acuoso de relevancia biologica que imita las condiciones fisiologicas humanas, las part¡culas de fenofibrato se caracterizan por una distribucion de tamano de part¡cula estable que tiene un tamano de part¡cula promedio efectivo de menos de 2000 nm. Reivindicacion 25: La forma de dosificacion de la reivindicacion 1 caracterizada porque adem s comprende uno o m s agentes activos seleccionados del grupo que consiste en agentes antihiperglucemicos, estatinas, inhibidores de HMGCoA reductasa y antihipertensivos.
ARP090101116A 2008-03-28 2009-03-27 Formas de dosificacion de fenofibrato AR072135A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/058,497 US20080241070A1 (en) 2000-09-21 2008-03-28 Fenofibrate dosage forms

Publications (1)

Publication Number Publication Date
AR072135A1 true AR072135A1 (es) 2010-08-11

Family

ID=40846436

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090101116A AR072135A1 (es) 2008-03-28 2009-03-27 Formas de dosificacion de fenofibrato

Country Status (7)

Country Link
US (1) US20080241070A1 (es)
EP (1) EP2271316A2 (es)
JP (1) JP2011516421A (es)
AR (1) AR072135A1 (es)
CA (1) CA2719811A1 (es)
TW (1) TW201006466A (es)
WO (1) WO2009120919A2 (es)

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CN102292088B (zh) 2009-02-23 2014-01-29 奈米瑞斯公司 普利醇纳米粒子
CA2844073C (en) 2010-08-23 2015-10-13 NanoRx, Inc. Policosanol nanoparticles
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US20140255480A1 (en) * 2011-09-07 2014-09-11 Ethypharm Pharmaceutical formulation of nanonized fenofibrate
US8722083B2 (en) * 2012-06-25 2014-05-13 Mylan, Inc. Fenofibrate formulation
US9439860B2 (en) 2012-06-25 2016-09-13 Mylan, Inc. Fenofibrate formulation
IN2014DN11044A (es) * 2012-06-25 2015-09-25 Mylan Inc
WO2014091318A1 (en) 2012-12-11 2014-06-19 Lupin Atlantis Holdings, S.A. Reduced dose pharmaceutical compositions of fenofibrate
BR112016022734B1 (pt) 2014-04-30 2020-12-01 Kimberly-Clark Worldwide, Inc. método para redução do estresse oxidativo das células, método para redução da apoptose de células induzida pelo estresse oxidativo e método para redução do fotodano das células
BR112016023653B1 (pt) 2014-04-30 2020-12-08 Kimberly-Clark Worldwide, Inc composição tópica
AU2014392629B2 (en) 2014-04-30 2021-04-01 Kimberly-Clark Worldwide, Inc. Use of Undaria extract to reduce signs of skin aging
BR112016023890B1 (pt) 2014-04-30 2020-12-01 Kimberly-Clark Worldwide, Inc métodos para reduzir sinais de envelhecimento da pele, para aumentar a adipogênese da face e do corpo e para aumentar a lipogênese da face e do corpo
DK3928772T3 (da) 2020-06-26 2024-08-19 Algiax Pharmaceuticals Gmbh Nanopartikulær sammensætning
WO2022183281A1 (en) * 2021-03-03 2022-09-09 Mcmaster Christopher R Compounds and treatments for muscular dystrophy

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Also Published As

Publication number Publication date
US20080241070A1 (en) 2008-10-02
WO2009120919A3 (en) 2010-11-04
EP2271316A2 (en) 2011-01-12
WO2009120919A2 (en) 2009-10-01
CA2719811A1 (en) 2009-10-01
JP2011516421A (ja) 2011-05-26
TW201006466A (en) 2010-02-16

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