AR070158A1 - Compuesto de benzamida composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para antagonizar selectivamente los rceptores opioides kappa - Google Patents
Compuesto de benzamida composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para antagonizar selectivamente los rceptores opioides kappaInfo
- Publication number
- AR070158A1 AR070158A1 ARP090100098A ARP090100098A AR070158A1 AR 070158 A1 AR070158 A1 AR 070158A1 AR P090100098 A ARP090100098 A AR P090100098A AR P090100098 A ARP090100098 A AR P090100098A AR 070158 A1 AR070158 A1 AR 070158A1
- Authority
- AR
- Argentina
- Prior art keywords
- manufacture
- pharmaceutical composition
- kappa
- rceptors
- benzamida
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un compuesto de benzamida que es 3-fluoro-4-[4-[2-(3,5-dimetilfenil)pirrolidin-1-il-metil]fenoxi]benzamida, o (S)-3-fluoro-4-[4-[2-(3,5-dimetilfenil)pirrolidin-1-il-metil]fenoxi]benzamida, o una sal farmacéuticamente aceptable del mismo. Composicion farmacéutica que lo comprende. Uso de dicho compuesto para la manufactura de un medicamento util para antagonizar selectivamente los receptores opioides kappa, como ser para tratar la abstinencia y ansiedad por trastorno de uso de alcohol etílico, y/o depresion, o esquizofrenia. Uso de dicho compuesto junto con un inhibidor de reabsorcion de norepinefrina tricíclica de la amina terciaria seleccionado de amitriptilina, clomipramina, doxepina, imipramina y (+)-trimipamina, o una sal farmacéuticamente aceptable de las mismas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08380012 | 2008-01-22 | ||
| US3912108P | 2008-03-25 | 2008-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070158A1 true AR070158A1 (es) | 2010-03-17 |
Family
ID=40876972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100098A AR070158A1 (es) | 2008-01-22 | 2009-01-13 | Compuesto de benzamida composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para antagonizar selectivamente los rceptores opioides kappa |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US7709522B2 (es) |
| EP (1) | EP2252581B1 (es) |
| JP (1) | JP5345637B2 (es) |
| KR (1) | KR101172170B1 (es) |
| CN (1) | CN101925576B (es) |
| AR (1) | AR070158A1 (es) |
| AU (1) | AU2009206653B2 (es) |
| BR (1) | BRPI0907382B8 (es) |
| CA (1) | CA2713025C (es) |
| CO (1) | CO6290644A2 (es) |
| CY (1) | CY1113071T1 (es) |
| DK (1) | DK2252581T3 (es) |
| DO (1) | DOP2010000222A (es) |
| EA (1) | EA017484B1 (es) |
| EC (1) | ECSP10010365A (es) |
| ES (1) | ES2388708T3 (es) |
| HK (1) | HK1146822A1 (es) |
| HR (1) | HRP20120558T1 (es) |
| IL (1) | IL206038A (es) |
| JO (1) | JO2797B1 (es) |
| MA (1) | MA32751B1 (es) |
| MX (1) | MX2010007849A (es) |
| MY (1) | MY163014A (es) |
| NZ (1) | NZ586225A (es) |
| PE (1) | PE20091317A1 (es) |
| PL (1) | PL2252581T3 (es) |
| PT (1) | PT2252581E (es) |
| SI (1) | SI2252581T1 (es) |
| TN (1) | TN2010000306A1 (es) |
| TW (1) | TWI422369B (es) |
| UA (1) | UA100715C2 (es) |
| WO (1) | WO2009094260A1 (es) |
| ZA (1) | ZA201003908B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY31604A1 (es) * | 2008-01-22 | 2009-08-31 | Compuestos tricíclicos y uso de los mismos | |
| NZ586225A (en) * | 2008-01-22 | 2012-05-25 | Lilly Co Eli | Kappa selective opioid receptor antagonist |
| WO2013040321A1 (en) * | 2011-09-15 | 2013-03-21 | University Of Kansas | Kappa opioid receptor effectors and uses thereof |
| EP2758134B1 (en) | 2011-09-19 | 2019-05-29 | Carmel - Haifa University Economic Corporation Ltd. | Buprenorphine for the treatment of acute suicidality |
| WO2013086496A2 (en) | 2011-12-09 | 2013-06-13 | Research Triangle Institute | 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| US9283196B1 (en) | 2013-01-30 | 2016-03-15 | MediSynergics, LLC | Cycloalkyl-diamines for CNS disorders |
| JP2016519161A (ja) * | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| US10316021B2 (en) * | 2016-11-28 | 2019-06-11 | Pfizer Inc. | Heteroarylphenoxy benzamide kappa opioid ligands |
| BR112019019157A2 (pt) | 2017-03-17 | 2020-04-14 | Blackthorn Therapeutics Inc | antagonistas de receptor de capa-opiode e produtos e métodos relacionados aos mesmos |
| JP6480616B1 (ja) | 2018-02-08 | 2019-03-13 | 有限会社 ディオン光学技研 | 照準スコープ |
| US11266627B1 (en) | 2021-05-04 | 2022-03-08 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| US12161622B2 (en) | 2021-05-04 | 2024-12-10 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| AU2022268720A1 (en) | 2021-05-04 | 2023-12-21 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| IL314176A (en) * | 2022-01-10 | 2024-09-01 | Janssen Pharmaceuticals Inc | Compositions and methods for treating depression |
| KR20240132479A (ko) * | 2022-01-10 | 2024-09-03 | 얀센 파마슈티칼즈, 인코포레이티드 | 우울증 치료를 위한 조성물 및 방법 |
| AU2023231767A1 (en) * | 2022-03-07 | 2024-10-24 | Janssen Pharmaceuticals, Inc. | Compositions comprising aticaprant |
| TW202345796A (zh) | 2022-03-07 | 2023-12-01 | 美商健生醫藥公司 | 阿替卡普蘭（ａｔｉｃａｐｒａｎｔ）之形式 |
| KR20240158951A (ko) * | 2022-03-07 | 2024-11-05 | 얀센 파마슈티칼즈, 인코포레이티드 | 결정질 아티카프란트의 순수한 형태 |
| JP7176142B1 (ja) | 2022-03-09 | 2022-11-21 | 直迪 清瀬 | 各アルコール飲用者において飲用し得るアルコール飲料の種類に対応する飲用量の上限値に関する情報を提供するシステム |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457208A (en) | 1993-06-21 | 1995-10-10 | Regents Of The University Of Minnesota | Kappa opioid receptor antagonists |
| ATE231865T1 (de) * | 1999-05-12 | 2003-02-15 | Hoffmann La Roche | Imidazodiazepinderivate |
| US20020052365A1 (en) * | 2000-10-05 | 2002-05-02 | Mohler Hanns | Selective anxiolytic therapeutic agents |
| AU2002231206A1 (en) | 2000-12-21 | 2002-07-01 | The Mclean Hospital Corporation | Treatment of depression |
| US6974824B2 (en) | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
| DK1490344T3 (da) * | 2002-03-28 | 2008-06-16 | Wisys Technology Found Inc | Anxiolytiske midler med reducerede sedative og ataktiske bivirkninger |
| WO2004026305A1 (en) | 2002-09-19 | 2004-04-01 | Eli Lilly And Company | Diaryl ethers as opioid receptor antagonist |
| CA2518194A1 (en) | 2003-03-07 | 2004-09-23 | Eli Lilly And Company | 6-substituted nicotinamide derivatives as opioid receptor antagonists |
| BRPI0408108A (pt) | 2003-03-07 | 2006-03-01 | Lilly Co Eli | composto, composição farmacêutica, métodos para bloquear em receptor mu, kappa, delta ou uma combinação de receptores dos mesmos em um mamìfero, para tratar ou prevenir obesidade e doenças relacionadas e para suprimir apetite, e, uso de um composto |
| EP1697307B1 (en) | 2003-12-12 | 2014-03-12 | Eli Lilly & Company | Opioid receptor antagonists |
| WO2005066164A1 (en) | 2003-12-22 | 2005-07-21 | Eli Lilly And Company | Opioid receptor antagonists |
| CA2558568A1 (en) | 2004-03-12 | 2005-09-29 | Eli Lilly And Company | Opioid receptor antagonists |
| ES2308471T3 (es) | 2004-03-12 | 2008-12-01 | Eli Lilly And Company | Antagonistas de receptores de opioides. |
| EP1729759A4 (en) | 2004-03-12 | 2008-04-02 | Mclean Hospital Corp | SALVINORINE DERIVATIVES AND ITS USES |
| ES2379362T3 (es) | 2004-03-15 | 2012-04-25 | Eli Lilly And Company | Antagonistas del receptor opioide |
| ATE420858T1 (de) | 2004-03-15 | 2009-01-15 | Lilly Co Eli | 4-(5-(aminomethyl)-indol-1- ylmethyl)benzamidderivate und verwandte verbindungen als opioidrezeptorantagonisten zur behandlung von fettleibigkeit |
| WO2007067714A2 (en) | 2005-12-08 | 2007-06-14 | The Mclean Hospital Corporation | Treatment of sequelae of psychiatric disorders |
| CA2646899C (en) | 2006-04-04 | 2014-05-06 | Holger Lars Hermann | Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders |
| CN102516115B (zh) | 2006-08-09 | 2016-05-11 | 史密丝克莱恩比彻姆公司 | 作为阿片样物质受体的拮抗剂或反向激动剂的新型化合物 |
| JP2010500372A (ja) | 2006-08-09 | 2010-01-07 | スミスクライン ビーチャム コーポレーション | オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物 |
| CN101511808A (zh) | 2006-09-08 | 2009-08-19 | 辉瑞产品公司 | 二芳基醚衍生物及其用途 |
| NZ586225A (en) * | 2008-01-22 | 2012-05-25 | Lilly Co Eli | Kappa selective opioid receptor antagonist |
-
2009
- 2009-01-13 NZ NZ586225A patent/NZ586225A/en unknown
- 2009-01-13 MY MYPI2010003437A patent/MY163014A/en unknown
- 2009-01-13 DK DK09703808.7T patent/DK2252581T3/da active
- 2009-01-13 PE PE2009000036A patent/PE20091317A1/es active IP Right Grant
- 2009-01-13 PL PL09703808T patent/PL2252581T3/pl unknown
- 2009-01-13 PT PT09703808T patent/PT2252581E/pt unknown
- 2009-01-13 US US12/352,869 patent/US7709522B2/en active Active
- 2009-01-13 SI SI200930326T patent/SI2252581T1/sl unknown
- 2009-01-13 EP EP09703808A patent/EP2252581B1/en active Active
- 2009-01-13 CA CA2713025A patent/CA2713025C/en active Active
- 2009-01-13 AU AU2009206653A patent/AU2009206653B2/en active Active
- 2009-01-13 CN CN2009801026504A patent/CN101925576B/zh active Active
- 2009-01-13 ES ES09703808T patent/ES2388708T3/es active Active
- 2009-01-13 EA EA201070877A patent/EA017484B1/ru not_active IP Right Cessation
- 2009-01-13 JP JP2010543182A patent/JP5345637B2/ja active Active
- 2009-01-13 KR KR1020107016401A patent/KR101172170B1/ko active IP Right Grant
- 2009-01-13 AR ARP090100098A patent/AR070158A1/es not_active Application Discontinuation
- 2009-01-13 BR BRPI0907382A patent/BRPI0907382B8/pt active IP Right Grant
- 2009-01-13 JO JO200915A patent/JO2797B1/en active
- 2009-01-13 WO PCT/US2009/030811 patent/WO2009094260A1/en active Application Filing
- 2009-01-13 MX MX2010007849A patent/MX2010007849A/es active IP Right Grant
- 2009-01-13 TW TW098101083A patent/TWI422369B/zh active
- 2009-01-13 UA UAA201008931A patent/UA100715C2/ru unknown
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2010
- 2010-04-09 US US12/757,451 patent/US8173695B2/en active Active
- 2010-05-27 IL IL206038A patent/IL206038A/en active IP Right Grant
- 2010-06-01 ZA ZA2010/03908A patent/ZA201003908B/en unknown
- 2010-06-30 TN TN2010000306A patent/TN2010000306A1/fr unknown
- 2010-07-19 MA MA33041A patent/MA32751B1/fr unknown
- 2010-07-20 DO DO2010000222A patent/DOP2010000222A/es unknown
- 2010-07-22 EC EC2010010365A patent/ECSP10010365A/es unknown
- 2010-08-12 CO CO10099271A patent/CO6290644A2/es active IP Right Grant
-
2011
- 2011-01-24 HK HK11100691.9A patent/HK1146822A1/xx unknown
-
2012
- 2012-07-06 HR HRP20120558AT patent/HRP20120558T1/hr unknown
- 2012-08-24 CY CY20121100765T patent/CY1113071T1/el unknown
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Legal Events
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