AR069500A1 - Metodos de tratamiento de la esteatohepatitis no alcoholica (nash ) utilizando productos de cisteamina - Google Patents
Metodos de tratamiento de la esteatohepatitis no alcoholica (nash ) utilizando productos de cisteaminaInfo
- Publication number
- AR069500A1 AR069500A1 ARP080105211A ARP080105211A AR069500A1 AR 069500 A1 AR069500 A1 AR 069500A1 AR P080105211 A ARP080105211 A AR P080105211A AR P080105211 A ARP080105211 A AR P080105211A AR 069500 A1 AR069500 A1 AR 069500A1
- Authority
- AR
- Argentina
- Prior art keywords
- cellulose
- phthalate
- composition
- acetate
- alcoholic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Reivindicacion 1: Uso de un producto de cisteamina, para la elaboracion de un medicamento para el tratamiento de un paciente que sufre de enfermedad de hígado graso. Reivindicacion 3: Uso de una composicion que comprende cisteamina o cistamina, o una sal farmacéuticamente aceptable de las mismas, para la elaboracion de un medicamento para el tratamiento de un paciente que sufre de enfermedad de hígado graso no alcoholico (NAFLD) o de esteatohepatitis no alcoholica (NASH). Reivindicacion 12: El uso de la reivindicacion 8, en donde la forma de dosificacion de liberacion retardada o controlada comprende un recubrimiento entérico que libera la composicion de cisteamina cuando la composicion llega al intestino delgado o a una region del tracto gastrointestinal de un sujeto en el cual el pH es mayor a aproximadamente un pH de 4,5. Reivindicacion 13: El uso de la reivindicacion 12, en donde la composicion comprende un recubrimiento seleccionado del grupo integrado por laca, gelatina polimerizada, copolímero de ácido metacrílico tipo C NF, butirato ftalato de celulosa, hidrogeno ftalato de celulosa, propionato ftalato de celulosa, ftalato de polivinil acetato (PVAP), acetato ftalato de celulosa (CAP), acetato trimelitato de celulosa (CAT), ftalato de hidroxipropil metilcelulosa, acetato de hidroxipropil metilcelulosa, succinato de dioxipropil metilcelulosa, carboximetil etilcelulosa (CMEC), acetato succinato de hidroxipropil metilcelulosa (HPMCAS), y polímeros y copolímeros de ácido acrílico, normalmente formados a partir de acrilato de metilo, acrilato de etilo, metacrilato de metilo y/o metacrilato de etilo con copolímeros de ésteres de ácido acrílico y metacrílico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99151707P | 2007-11-30 | 2007-11-30 | |
US8539708P | 2008-07-31 | 2008-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069500A1 true AR069500A1 (es) | 2010-01-27 |
Family
ID=40679016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080105211A AR069500A1 (es) | 2007-11-30 | 2008-11-28 | Metodos de tratamiento de la esteatohepatitis no alcoholica (nash ) utilizando productos de cisteamina |
Country Status (26)
Country | Link |
---|---|
US (5) | US7994226B2 (es) |
EP (2) | EP2636404B1 (es) |
JP (3) | JP5583022B2 (es) |
KR (1) | KR20100091219A (es) |
CN (2) | CN104825430B (es) |
AR (1) | AR069500A1 (es) |
AU (1) | AU2008329628B2 (es) |
BR (1) | BRPI0819690B8 (es) |
CA (1) | CA2706768C (es) |
CL (1) | CL2008003582A1 (es) |
CY (1) | CY1114126T1 (es) |
DK (1) | DK2214480T3 (es) |
ES (1) | ES2417179T3 (es) |
HK (1) | HK1141945A1 (es) |
HR (1) | HRP20130590T1 (es) |
IL (2) | IL205909B (es) |
MX (2) | MX2010005921A (es) |
MY (1) | MY156316A (es) |
NZ (1) | NZ585732A (es) |
PL (1) | PL2214480T3 (es) |
PT (1) | PT2214480E (es) |
RU (1) | RU2498795C2 (es) |
SG (1) | SG10201403200RA (es) |
TW (2) | TWI535435B (es) |
WO (1) | WO2009070781A1 (es) |
ZA (1) | ZA201003670B (es) |
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US8026284B2 (en) | 2006-01-27 | 2011-09-27 | The Regents Of The University Of California | Enterically coated cystamine, cysteamine and derivatives thereof |
AR069500A1 (es) | 2007-11-30 | 2010-01-27 | Univ California | Metodos de tratamiento de la esteatohepatitis no alcoholica (nash ) utilizando productos de cisteamina |
JP5800368B2 (ja) * | 2010-05-19 | 2015-10-28 | 興和株式会社 | 非アルコール性脂肪性肝炎の予防及び/又は治療剤 |
AU2011263423B2 (en) * | 2010-06-08 | 2016-10-20 | Krisani Biosciences (P) Ltd | Cysteamine derivatives and their use in the treatment of NASH |
PL2598142T3 (pl) * | 2010-07-28 | 2016-06-30 | Orchid Chemicals And Pharmaceuticals Ltd | Związki eteru difenylowego do zastosowania w leczeniu zaburzeń wątroby |
WO2014045293A1 (en) * | 2012-09-24 | 2014-03-27 | Krisani Bioscience (P) Ltd. | Fatty acid amides with a cysteamine or an acetylated cysteamine group and uses thereof |
US20130085075A1 (en) * | 2011-06-06 | 2013-04-04 | Meso Scale Technologies, Llc | Diagnostic methods for liver disorders |
EP2755480B1 (en) | 2011-09-16 | 2021-03-31 | Galectin Therapeutics Inc. | Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease |
BR112014009789A2 (pt) * | 2011-10-26 | 2017-04-25 | Seattle Children's Res Inst | cisteamina no tratamento da doença fibrótica |
AU2012340670B2 (en) * | 2011-11-22 | 2016-12-22 | The Regents Of The University Of California | Cysteamine and/or cystamine for treating ischemic injury |
CA2869054A1 (en) * | 2012-03-29 | 2013-10-03 | Halo Therapeutics, Llc | Dosage forms of halofuginone and methods of use |
ES2848538T3 (es) | 2012-06-06 | 2021-08-10 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de enfermedades asociadas con elevada óxido nítrico sintasa inducible |
US20140314841A1 (en) | 2013-04-19 | 2014-10-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Use of Cysteamine and Derivatives Thereof to Suppress Tumor Metastases |
TWI649100B (zh) * | 2013-06-17 | 2019-02-01 | 地平線罕見醫學製藥有限責任公司 | 延遲釋放型半胱胺珠粒調配物,以及其製備及使用方法 |
US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
RU2664696C2 (ru) * | 2014-04-18 | 2018-08-21 | ЭлДжи КЕМ, ЛТД. | Композиция для предотвращения или лечения жировых болезней печени |
MX2017011363A (es) * | 2015-03-03 | 2018-03-01 | Kohjin Life Sciences Co Ltd | Composicion para corregir o prevenir higado graso no alcoholico. |
KR20180034466A (ko) * | 2015-07-02 | 2018-04-04 | 호리즌 오펀 엘엘씨 | Ado-저항성 시스테아민 유사체 및 그의 용도 |
RU2595815C1 (ru) * | 2015-07-13 | 2016-08-27 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации | Способ лечения больных неалкогольным стеатогепатитом на фоне метаболического синдрома |
WO2017087532A1 (en) * | 2015-11-16 | 2017-05-26 | The Regents Of The University Of California | Methods of treating non-alcoholic steatohepatitis (nash) using cysteamine compounds |
US10143665B2 (en) | 2015-11-17 | 2018-12-04 | Horizon Orphan Llc | Methods for storing cysteamine formulations and related methods of treatment |
US11173135B2 (en) | 2016-03-17 | 2021-11-16 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
ITUA20161799A1 (it) * | 2016-03-18 | 2017-09-18 | Recordati Ind Chimica E Farmaceutica S P A | Composizione farmaceutica a rilascio prolungato comprendente cisteamina o un suo sale |
DK3634411T3 (da) * | 2017-06-08 | 2023-12-04 | N Gene Res Laboratories Inc | Fremgangsmåder til behandling af NASH og til forebyggelse af NASH-induceret HCC |
US10632092B2 (en) | 2017-08-30 | 2020-04-28 | First Fruits Business Ministry, Llc | Composition for and method to increase serum adiponectin and reduce body fat |
US11612576B2 (en) | 2017-09-20 | 2023-03-28 | Thiogenesis Therapeutics, Inc. | Methods for the treatment of cysteamine sensitive disorders |
KR102177304B1 (ko) * | 2018-07-23 | 2020-11-10 | 제이투에이치바이오텍 (주) | 비알콜성 지방간염의 예방 또는 치료용 약학 조성물 |
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US20220135524A1 (en) | 2019-03-26 | 2022-05-05 | The Regents Of The University Of California | Substituted amino-thiol and amino-disulfide compounds, and uses thereof |
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WO2007121545A1 (en) * | 2006-04-20 | 2007-11-01 | Universidade Estadual De Campinas-Unicamp | S-nitrosothiols containing compositions for the treatment of fatty liver diseases, obesity and other diseases associated with the metabolic syndrome and the use of such compositions |
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AR069500A1 (es) * | 2007-11-30 | 2010-01-27 | Univ California | Metodos de tratamiento de la esteatohepatitis no alcoholica (nash ) utilizando productos de cisteamina |
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2008
- 2008-11-28 AR ARP080105211A patent/AR069500A1/es unknown
- 2008-11-28 TW TW103146662A patent/TWI535435B/zh not_active IP Right Cessation
- 2008-11-28 CN CN201510122652.7A patent/CN104825430B/zh not_active Expired - Fee Related
- 2008-11-28 AU AU2008329628A patent/AU2008329628B2/en not_active Ceased
- 2008-11-28 PL PL08853916T patent/PL2214480T3/pl unknown
- 2008-11-28 ES ES08853916T patent/ES2417179T3/es active Active
- 2008-11-28 NZ NZ585732A patent/NZ585732A/en not_active IP Right Cessation
- 2008-11-28 BR BRPI0819690A patent/BRPI0819690B8/pt not_active IP Right Cessation
- 2008-11-28 CA CA2706768A patent/CA2706768C/en not_active Expired - Fee Related
- 2008-11-28 KR KR1020107013228A patent/KR20100091219A/ko not_active Application Discontinuation
- 2008-11-28 MX MX2010005921A patent/MX2010005921A/es active IP Right Grant
- 2008-11-28 EP EP13154059.3A patent/EP2636404B1/en not_active Not-in-force
- 2008-11-28 PT PT88539168T patent/PT2214480E/pt unknown
- 2008-11-28 EP EP08853916A patent/EP2214480B1/en active Active
- 2008-11-28 MY MYPI2010002498A patent/MY156316A/en unknown
- 2008-11-28 US US12/745,504 patent/US7994226B2/en active Active
- 2008-11-28 SG SG10201403200RA patent/SG10201403200RA/en unknown
- 2008-11-28 CN CN200880125923.2A patent/CN101932238B/zh not_active Expired - Fee Related
- 2008-11-28 RU RU2010126631/15A patent/RU2498795C2/ru not_active IP Right Cessation
- 2008-11-28 JP JP2010536206A patent/JP5583022B2/ja active Active
- 2008-11-28 MX MX2015010032A patent/MX360827B/es unknown
- 2008-11-28 TW TW097146491A patent/TWI478710B/zh not_active IP Right Cessation
- 2008-11-28 DK DK08853916.8T patent/DK2214480T3/da active
- 2008-11-28 WO PCT/US2008/085064 patent/WO2009070781A1/en active Application Filing
- 2008-12-01 CL CL2008003582A patent/CL2008003582A1/es unknown
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2010
- 2010-05-23 IL IL205909A patent/IL205909B/en active IP Right Grant
- 2010-05-24 ZA ZA2010/03670A patent/ZA201003670B/en unknown
- 2010-09-03 HK HK10108405.0A patent/HK1141945A1/xx not_active IP Right Cessation
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2011
- 2011-07-15 US US13/183,990 patent/US8263662B2/en active Active
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2012
- 2012-09-10 US US13/608,134 patent/US9149448B2/en active Active
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2013
- 2013-06-27 HR HRP20130590AT patent/HRP20130590T1/hr unknown
- 2013-06-27 CY CY20131100522T patent/CY1114126T1/el unknown
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2014
- 2014-07-17 JP JP2014146814A patent/JP6121951B2/ja active Active
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2015
- 2015-09-28 US US14/867,386 patent/US9511038B2/en active Active
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2016
- 2016-11-28 US US15/362,782 patent/US10307386B2/en active Active
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2017
- 2017-03-30 JP JP2017066622A patent/JP2017165735A/ja active Pending
- 2017-09-19 IL IL254586A patent/IL254586A0/en unknown
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