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AR065858A1 - Metodo para preparar el inhibidor de triptasa [ 4-(5-aminoetil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona. - Google Patents

Metodo para preparar el inhibidor de triptasa [ 4-(5-aminoetil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona.

Info

Publication number
AR065858A1
AR065858A1 ARP080101260A ARP080101260A AR065858A1 AR 065858 A1 AR065858 A1 AR 065858A1 AR P080101260 A ARP080101260 A AR P080101260A AR P080101260 A ARP080101260 A AR P080101260A AR 065858 A1 AR065858 A1 AR 065858A1
Authority
AR
Argentina
Prior art keywords
piperidin
bromo
methyl
fluoro
phenyl
Prior art date
Application number
ARP080101260A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR065858A1 publication Critical patent/AR065858A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion 1: Procedimiento para preparar [4-(5-aminometil-2-fluoro-fenil)-piperidin-1il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-meta nona que comprende acoplar por imitacion el éster de2,5-dioxo-pirrolidin-1-ilo de ácido 4-bromo-3-metil-5-propoxitiofeno-2-carboxílico con hidrocloruro de 2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-il-bencil)-acetamida y una base fuerte o una base amina terciaria en un disolvente alcoholico para producir 2,2,2-trifluoro-N-{3-[1-(4-Bromo-3-metil-5-propoxi-tiofeno-2-carbonil)-piperidin-4-il]-4-fluoro-bencil}-acetamida y desproteger la 2,2,2-trifluoro-N-{3-[1-(4-Bromo-3-metil-5-propoxi-tiofeno-2-carbonil)-piperidin-4-il]-4-fluro-bencil}-acetamida con una base para producir [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo -3-metil-5-propoxy-thiophen-2-il)-metanona
ARP080101260A 2007-03-29 2008-03-27 Metodo para preparar el inhibidor de triptasa [ 4-(5-aminoetil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona. AR065858A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90884407P 2007-03-29 2007-03-29

Publications (1)

Publication Number Publication Date
AR065858A1 true AR065858A1 (es) 2009-07-08

Family

ID=39535396

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101260A AR065858A1 (es) 2007-03-29 2008-03-27 Metodo para preparar el inhibidor de triptasa [ 4-(5-aminoetil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona.

Country Status (3)

Country Link
AR (1) AR065858A1 (es)
TW (1) TW200904811A (es)
WO (1) WO2008121666A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20100235A1 (es) * 2008-08-22 2010-03-29 Sanofi Aventis [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
US9024041B2 (en) 2010-04-08 2015-05-05 Respivert Ltd. P38 MAP kinase inhibitors
WO2011158044A2 (en) 2010-06-17 2011-12-22 Respivert Limited Respiratory formulations and compounds for use therein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2005000039A (es) * 2004-03-26 2005-10-31 Aventis Pharma Inc Hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)- piperidin-1-il]-(4-bomo-3-metil-5-propoxi-tiofen-2-il)-metanona como un inhibidor de la triptasa de mastocitos

Also Published As

Publication number Publication date
TW200904811A (en) 2009-02-01
WO2008121666A1 (en) 2008-10-09

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