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AR065621A1 - Derivados de amino-piridina, una composicion farmaceutica que los comprende y su uso como medicamento para el tratamiento de enfermedades asociadas al sistema inmune activado. - Google Patents

Derivados de amino-piridina, una composicion farmaceutica que los comprende y su uso como medicamento para el tratamiento de enfermedades asociadas al sistema inmune activado.

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Publication number
AR065621A1
AR065621A1 ARP080100929A ARP080100929A AR065621A1 AR 065621 A1 AR065621 A1 AR 065621A1 AR P080100929 A ARP080100929 A AR P080100929A AR P080100929 A ARP080100929 A AR P080100929A AR 065621 A1 AR065621 A1 AR 065621A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydroxy
carboxylic acid
carboxy
och2
Prior art date
Application number
ARP080100929A
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English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR065621A1 publication Critical patent/AR065621A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados amino-piridina, con su preparacion y con su uso como compuestos farmacéuticamente activos. Dichos compuestos actuan en particular como agentes inmunomoduladores. Reivindicacion 1: Compuestos de formula (1) en la cual A representa loscompuestos de formulas (2) en donde los asteriscos indican el enlace que está unido al grupo piridina de formula (1); R1 representa hidrogeno, o alquilo C1-3; R2 representa alquilo C1-4; o R1 y R2, junto con el átomo de nitrogeno al cual estánunidos, forman un anillo pirrolidina, piperidina, o morfolina; R3 representa alquilo C1-4, o cloro; R4 representa hidrogeno, alquilo C1-4, alcoxilo C1-3, o halogeno; R5 representa hidrogeno, alquilo C1-4, alcoxilo C1-3, o halogeno; R6 representahidrogeno, hidroxi-alquilo C1-5, 2,3-dihidroxipropilo, di-(hidroxi-alquil C1-4)-alquilo C1-4, -CH2-(CH2)k-NR61R62, -CH2-(CH2)k-NHSO2R63, -(CH2)nCH(OH)-CH2-NHSO2R63, -CH2-(CH2)k-NHCOR64, -(CH2)CH(OH)-CH2-NHCOR64, -CH2-(CH2)n-CONR61R62, -CO-NHR61, 1-(3-carboxi-acetidinil)-2-acetilo, 1-(2-carboxi-pirrolidinil)-2-acetilo, 1-(3-carboxi-pirrolidinil)-2-acetilo, 1-(3-carboxi-acetidinil)-3-propionilo, 1-(2-carboxi-pirrolidinil)-3-propionilo, 1-(3-carboxi-pirrolidinil)-3-propionilo, -(CH2)nCH(OH)-CH2-NR61R62, hidroxilo, alcoxilo C1-4, hidroxi-alcoxilo C2-5, di-(hidroxi-alquil C1-4)-alcoxilo C1-4, 2,3-dihidroxi-propoxilo, 2-hidroxi-3-metoxi-propoxilo, -OCH2-(CH2)m-NR61R62, 2-[ (ácido acetidin-3-carboxílico)-1-il]-etoxilo, 2-[(alquiléster C1-5 deácido acetidin-3-carboxílico)-1-il]-etoxilo, 2-[(ácido pirrolidin-3-carboxílico)-1-il]-etoxilo, 2-[(alquiléster C1-5 de ácido pirrolidin-3-carboxílico)-1-il]-etoxilo, -OCH2-CH(OH)-CH2-NR61R62, 3-[(ácido acetidin-3-carboxílico)-1-il]-2-hidroxipropoxilo, 3-[(alquiléster C1-5 de ácido acetidin-3-carboxílico)-1-il]-2-hidroxipropoxilo, 2-hidroxi-3-[(ácido pirrolidin-3-carboxílico)-1-il]-propoxilo, 2-hidroxi-3-[(alquiléster C1-5 de ácido pirrolidin-3-carboxílico)-1-il]-propoxilo, 2-hidroxi-3-[(ácido pirrolidin-2-carboxílico)-1-il]-propoxilo, 2- hidroxi-3-[(alquiléster C1-5 de ácido pirrolidin-2- carboxílico)-1-il]-propoxilo, -OCH2-(CH2)mNHSO2R63, -OCH2-CH(OH)-CH2NHSO2R63, -OCH2-(CH2)mNHCOR64, -OCH2-CH(OH)-CH2-NHCOR64, -NR61R62, -NHCO-R61, o -SO2NHR61; R61 representa hidrogeno, alquilo C1-3, 2-hidroxietilo, 2-hidroxi-1-hidroximetil-etilo, 2,3-dihidroxipropilo, carboximetilo, (alquilcarboxi C1-5)metilo, 2-carboxietilo, 2-(alquilcarboxi C1-5)etilo, o 2-aminoetilo;R62 representa hidrogeno, metilo, o etilo; R63 representa alquilo C1-3, metilamino, etilamino, o dimetilamino; R64 representa hidroxi-C1-2-alquilo, o R65R66N-alquilo C1-2; R65 y R66 representan de manera independiente hidrogeno, o metilo; krepresenta el entero 1, 2, o 3; m representa el entero 1o 2; n representa 0, 1, o 2; y R7 representa hidrogeno, alquilo C1-4, o halogeno; y sales de los mismos.
ARP080100929A 2007-03-16 2008-03-06 Derivados de amino-piridina, una composicion farmaceutica que los comprende y su uso como medicamento para el tratamiento de enfermedades asociadas al sistema inmune activado. AR065621A1 (es)

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IB2007050921 2007-03-16

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AR065621A1 true AR065621A1 (es) 2009-06-17

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ARP080100929A AR065621A1 (es) 2007-03-16 2008-03-06 Derivados de amino-piridina, una composicion farmaceutica que los comprende y su uso como medicamento para el tratamiento de enfermedades asociadas al sistema inmune activado.

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US (1) US8592460B2 (es)
EP (1) EP2125797B1 (es)
JP (2) JP2010521450A (es)
KR (1) KR101454944B1 (es)
CN (1) CN101627034B (es)
AR (1) AR065621A1 (es)
AU (1) AU2008227979B2 (es)
BR (1) BRPI0808789A2 (es)
CA (1) CA2679138C (es)
CY (1) CY1115087T1 (es)
DK (1) DK2125797T3 (es)
ES (1) ES2450750T3 (es)
HR (1) HRP20140335T1 (es)
IL (1) IL200911A0 (es)
MA (1) MA31290B1 (es)
MX (1) MX2009009597A (es)
NO (1) NO20093146L (es)
NZ (1) NZ580454A (es)
PL (1) PL2125797T3 (es)
PT (1) PT2125797E (es)
SI (1) SI2125797T1 (es)
TW (1) TW200902522A (es)
WO (1) WO2008114157A1 (es)

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