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AR058124A1 - Derivados de ftalazinona como inhibidores de parp-1 - Google Patents

Derivados de ftalazinona como inhibidores de parp-1

Info

Publication number
AR058124A1
AR058124A1 ARP060104580A ARP060104580A AR058124A1 AR 058124 A1 AR058124 A1 AR 058124A1 AR P060104580 A ARP060104580 A AR P060104580A AR P060104580 A ARP060104580 A AR P060104580A AR 058124 A1 AR058124 A1 AR 058124A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
compound
formula
substituted alkyl
ring
Prior art date
Application number
ARP060104580A
Other languages
English (en)
Inventor
Marc Hummersone
Muhammad Javaid
K A Menear
Jefferson Roberto Gomes
Niall M B Martin
Graeme C M Smith
Xiao Cockcroft
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of AR058124A1 publication Critical patent/AR058124A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un compuesto de formula (1): donde; A y B representan juntos un anillo aromático fusionado opcionalmente sustituido; D se selecciona entre: (i) un compuesto de formula (2), donde Y1 se selecciona enrte CH y N, Y2 se selecciona entre CH y N, Y3 se selecciona entre CH, CF y N; y (ii) un compuesto seleccionado del grupo de formulas (3), donde Q es O o S; RD es: un compuesto de formula (4), donde RN1 se selecciona entre H y C1-10alquilo opcionalmente sustituido; X se selecciona entre un enlace simple, NRN2, CRc3Rc4 y C=O; RN2 se selecciona entre H y C1-10alquilo opcionalmente sustituido; Rc3 y Rc4 se seleccionan independientemente entre H, R, C(=O)OR, donde R es C1-10 alquilo opcionalmente sustituido, C5-20 arilo opcionalmente sustituido o C3-20 heterociclilo opcionalmente sustituido; Y se selecciona ente NRN3 y CRc1Rc2; Rc1 y Rc2 se seleccionan independientemente entre H, R, C=(=O)OR, donde R es C1-10 alquilo opcionalmente sustituido, C5-20 arilo opcionalmente sustituido o C3-20 heterociclilo opcionalmente sustituido; Rc1 y Rc2, junto con el átomo de carbono al que están unidos, pueen formar un anillo C5-7 carbocíclico o heterocíclico fusionado a espiro opcionalmente sustituido; y cuando X es un enlace simple, RN1 y Rc2, junto con los átomos de N y C a los que están unidos, pueden formar un anillo C5-7 heterocíclico opcionalmente sustituido; y cuando X es CRc3Rc4, Rc2 y Rc4 pueden formar juntos un enlace adicional, de modo que haya un enlace doble entre los átomos sustituidos con Rc1y Rc3.
ARP060104580A 2005-10-19 2006-10-19 Derivados de ftalazinona como inhibidores de parp-1 AR058124A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72805005P 2005-10-19 2005-10-19
GBGB0521373.1A GB0521373D0 (en) 2005-10-20 2005-10-20 Pthalazinone derivatives
US82266306P 2006-08-17 2006-08-17

Publications (1)

Publication Number Publication Date
AR058124A1 true AR058124A1 (es) 2008-01-23

Family

ID=35458374

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104580A AR058124A1 (es) 2005-10-19 2006-10-19 Derivados de ftalazinona como inhibidores de parp-1

Country Status (12)

Country Link
US (2) US7470688B2 (es)
EP (1) EP1948642A1 (es)
JP (1) JP2009512671A (es)
AR (1) AR058124A1 (es)
AU (1) AU2006303038A1 (es)
BR (1) BRPI0617437A2 (es)
CA (1) CA2623703A1 (es)
GB (1) GB0521373D0 (es)
NZ (1) NZ567445A (es)
TW (1) TW200800964A (es)
UY (1) UY29870A1 (es)
WO (1) WO2007045877A1 (es)

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US7902193B2 (en) 2011-03-08
GB0521373D0 (en) 2005-11-30
JP2009512671A (ja) 2009-03-26
US7470688B2 (en) 2008-12-30
WO2007045877A1 (en) 2007-04-26
NZ567445A (en) 2011-03-31
US20090069303A1 (en) 2009-03-12
UY29870A1 (es) 2007-09-28
US20070093489A1 (en) 2007-04-26
EP1948642A1 (en) 2008-07-30

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