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AR057461A1 - Derivados de pirazol, proceso de preparacion, composiciones farmaceuticas y usos - Google Patents

Derivados de pirazol, proceso de preparacion, composiciones farmaceuticas y usos

Info

Publication number
AR057461A1
AR057461A1 ARP060103029A ARP060103029A AR057461A1 AR 057461 A1 AR057461 A1 AR 057461A1 AR P060103029 A ARP060103029 A AR P060103029A AR P060103029 A ARP060103029 A AR P060103029A AR 057461 A1 AR057461 A1 AR 057461A1
Authority
AR
Argentina
Prior art keywords
substituted
group
hydroxy
alkyl group
alkyl
Prior art date
Application number
ARP060103029A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34897416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR057461(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR057461A1 publication Critical patent/AR057461A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
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Abstract

La presente se refiere a compuestos de la formula (1) y a procesos para prepara tales compuestos, a su uso en el tratamiento de obesidad, trastornos psiquiátricos y neurologicos y a composiciones farmacéuticas que los contienen. Reivindicacion 1: Un compuesto de la formula (1) donde R1 representa un grupo R5O- en el que R5 representa un grupo alquilo C3-7 sustituido con uno o varios F o R5 representa un grupo alquilsulfonilo C3-7 que está opcionalmente sustituido con uno o varios F; R2 representa un grupo alquilo C1-4, hidroxi, F, Cl, o ciano, donde cada R2 está seleccionado, de modo independiente, cuando n es >1; R3 representa a) ciclohexilo opcionalmente sustituido con uno varios de los siguientes: hidroxi, F, amino, mono o dialquil C1-3-amino, carboxi o un grupo alcoxi C1-4-carbonilo b) piperidino sustituido con uno o arios hidroxi c) piperidino no sustituido pero solo cuando se aplica uno de los siguientes. r4 representa ciano o R1 representa 3-fluorpropilsulfoniloxi o R1 representa 3,3,3-trifluorpropoxi o R1 representa 3-fluorpropoxi o R2 es metilo d) fenilo sustituido con uno o varios de los siguientes: hidroxi, halo o un grupo alquilo C1-4 e) piridilo sustituido con un grupo alquilo C1-4 o f) un grupo alquilo C4-9; R4 representa ciano o metilo; y n es 1, 2 o 3 y sus sales farmacéuticamente aceptables.
ARP060103029A 2005-07-19 2006-07-14 Derivados de pirazol, proceso de preparacion, composiciones farmaceuticas y usos AR057461A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0514738.4A GB0514738D0 (en) 2005-07-19 2005-07-19 Therapeutic agents

Publications (1)

Publication Number Publication Date
AR057461A1 true AR057461A1 (es) 2007-12-05

Family

ID=34897416

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103029A AR057461A1 (es) 2005-07-19 2006-07-14 Derivados de pirazol, proceso de preparacion, composiciones farmaceuticas y usos

Country Status (16)

Country Link
US (1) US20080287517A1 (es)
EP (1) EP1910331A1 (es)
JP (1) JP2009501771A (es)
KR (1) KR20080032206A (es)
CN (1) CN101223159A (es)
AR (1) AR057461A1 (es)
AU (1) AU2006271499A1 (es)
CA (1) CA2615588A1 (es)
GB (1) GB0514738D0 (es)
IL (1) IL188388A0 (es)
MX (1) MX2008000891A (es)
NO (1) NO20080025L (es)
TW (1) TW200734324A (es)
UY (1) UY29678A1 (es)
WO (1) WO2007010217A1 (es)
ZA (1) ZA200800327B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100234438A1 (en) * 2006-06-20 2010-09-16 Leifeng Cheng Therapeutic agents
WO2007148061A1 (en) * 2006-06-20 2007-12-27 Astrazeneca Ab Therapeutic agents
EP1946777A1 (en) * 2007-01-16 2008-07-23 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline for preventing weight gain
ES2341522B1 (es) * 2008-12-18 2011-06-06 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituida en la posicion, 4 preparacion y composiciones farmaceuticas que comprenden los mismos.
WO2012174362A1 (en) 2011-06-17 2012-12-20 Research Triangle Institute Pyrazole derivatives as cannabinoid receptor 1 antagonists
CN109516955B (zh) * 2017-09-20 2022-07-26 华东师范大学 含氮五元芳香杂环化合物及其制备方法和应用
CN113274391B (zh) * 2021-06-01 2022-07-05 苏州大学 吡唑衍生物在制备p2y6r相关治疗动脉粥样硬化及抗炎药物中的应用
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EP1910331A1 (en) 2008-04-16
KR20080032206A (ko) 2008-04-14
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MX2008000891A (es) 2008-03-18
US20080287517A1 (en) 2008-11-20
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