AR054814A1 - Derivados de piridazina - Google Patents
Derivados de piridazinaInfo
- Publication number
- AR054814A1 AR054814A1 ARP060102856A ARP060102856A AR054814A1 AR 054814 A1 AR054814 A1 AR 054814A1 AR P060102856 A ARP060102856 A AR P060102856A AR P060102856 A ARP060102856 A AR P060102856A AR 054814 A1 AR054814 A1 AR 054814A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloalkyl
- alkyl
- alkoxy
- hydrogen
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Reivindicacion 1: Compuestos de la formula (1) en la que R1 es cicloalquilo, arilalquillo o ariloxialquilo; R2 es cicloalquillo, arilalquilo o ariloxialquilo; o R1 y R2 junto con los átomos de carbono Ca y Cb a los que están unidos forman el grupo (2) , R3 es hidrogeno, alquilo, cicloalquilo o trifluormetilo; R4 es bencilo, cicloalquilo, arilcicloalquilo, adamantilo, arilo o heterociclilo, en los que bencilo, cicloalquilo, arilcicloalquilo, arilo y heterociclilo están opcionalmente sustituidos de una a tres veces por sustituyentes elegidos con independencia entre sí entre alquilo, cicloalquilo, alcoxi, hidroxi, halogeno, trifluormetilo, trifluormetoxi, bencilo, fenilo y fenilo sustituido de una a tres veces por sustituyentes elegidos con independencia entre sí entre alquilo, alcoxi, hidroxi, cicloalquilo, halogeno y trifluormetilo; R5 es hidrogeno, alquilo, cicloalquilo o alcoxi; R6 es hidrogeno, alquilo, cicloalquilo o alcoxi; R7 es hidrogeno, alquilo, cicloalquilo o alcoxi; y sales y ésteres farmacéuticamente aceptables de los mismos; con la condicion de que se excluya la 3-(2-furanil)-5, 6, 7, 8-tetrahidro-5-metil-quinolina y de que en el caso de que R4 sea fenilo sin sustituir, por lo menos uno de los restos R5, R6 y R7 no sea hidrogeno ni metilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05106098 | 2005-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054814A1 true AR054814A1 (es) | 2007-07-18 |
Family
ID=36781523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102856A AR054814A1 (es) | 2005-07-05 | 2006-07-03 | Derivados de piridazina |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7678795B2 (es) |
| EP (1) | EP1904455B1 (es) |
| JP (1) | JP4787321B2 (es) |
| KR (1) | KR100979582B1 (es) |
| CN (1) | CN101528713B (es) |
| AR (1) | AR054814A1 (es) |
| AT (1) | ATE520670T1 (es) |
| AU (1) | AU2006265201C1 (es) |
| BR (1) | BRPI0613565A2 (es) |
| CA (1) | CA2612740C (es) |
| CL (1) | CL2009001936A1 (es) |
| CR (1) | CR9587A (es) |
| CY (1) | CY1112401T1 (es) |
| DK (1) | DK1904455T3 (es) |
| EC (1) | ECSP088082A (es) |
| ES (1) | ES2370039T3 (es) |
| HK (1) | HK1134087A1 (es) |
| HR (1) | HRP20110808T1 (es) |
| IL (1) | IL188182A (es) |
| MA (1) | MA29909B1 (es) |
| MX (1) | MX2007016352A (es) |
| MY (1) | MY144209A (es) |
| NO (1) | NO20076431L (es) |
| NZ (1) | NZ564260A (es) |
| PL (1) | PL1904455T3 (es) |
| PT (1) | PT1904455E (es) |
| RS (1) | RS51994B (es) |
| RU (1) | RU2401832C2 (es) |
| SI (1) | SI1904455T1 (es) |
| TW (1) | TWI323258B (es) |
| UA (1) | UA94052C2 (es) |
| WO (1) | WO2007003521A2 (es) |
| ZA (1) | ZA200710972B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7834178B2 (en) | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| MX2009001043A (es) | 2006-08-08 | 2009-02-06 | Sanofi Aventis | Imidazolidina-2,4-dionas sustituidas con arilaminoarilalquilo, procedimiento para preparalas, medicamentos que comprenden estos compuestos y su uso. |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009131958A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising triazine derivatives |
| WO2009131947A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyridazine derivatives |
| TW201014822A (en) | 2008-07-09 | 2010-04-16 | Sanofi Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| US8501940B2 (en) * | 2008-07-15 | 2013-08-06 | Hoffmann-La Roche Inc. | Tetrahydrocinnoline derivatives |
| US20100022572A1 (en) | 2008-07-18 | 2010-01-28 | Kowa Company, Ltd. | Novel spiro compound and medicine comprising the same |
| WO2010023931A1 (ja) | 2008-08-29 | 2010-03-04 | 興和株式会社 | １－アダマンチルアゼチジン－２－オン誘導体及びこれを含有する医薬 |
| JP5477973B2 (ja) | 2008-10-29 | 2014-04-23 | 興和株式会社 | １，２−ジアゼチジン−３−オン誘導体及びこれを含有する医薬 |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| US20100267706A1 (en) * | 2009-04-20 | 2010-10-21 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Pyridazine Derivatives |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| BR112012003973A2 (pt) | 2009-08-26 | 2015-09-08 | Sanofi Sa | hidratos de fluoroglicosídeo heteroaromático cristalinos, produtos farmacêuticos compreendendo estes compostos e seu uso |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012154967A1 (en) | 2011-05-12 | 2012-11-15 | Proteostasis Therapeutics, Inc. | Proteostasis regulators |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2015067575A1 (en) * | 2013-11-05 | 2015-05-14 | F. Hoffmann-La Roche Ag | 5,6,7,8-tetrahydro-5,8-methanocinnoline derivatives as rorc modulators for the treatment of autoimmune diseases |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| CA3042317A1 (en) * | 2016-11-01 | 2018-05-11 | F.Hoffmann-La Roche Ag | Pyridazine derivatives as rorc modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2474214A1 (en) * | 2002-02-05 | 2003-08-14 | Novo Nordisk A/S | Novel aryl- and heteroarylpiperazines |
| TWI314455B (en) * | 2002-12-10 | 2009-09-11 | Nippon Kayaku Kk | 3-phenyl-cinnoline derivatives and anti-tumor agent containing the same |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| JP2006522747A (ja) * | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 縮合１，２，４−トリアゾールの薬学的使用 |
-
2006
- 2006-06-26 JP JP2008519896A patent/JP4787321B2/ja not_active Expired - Fee Related
- 2006-06-26 UA UAA200801149A patent/UA94052C2/uk unknown
- 2006-06-26 ES ES06777461T patent/ES2370039T3/es active Active
- 2006-06-26 AT AT06777461T patent/ATE520670T1/de active
- 2006-06-26 KR KR1020087000144A patent/KR100979582B1/ko not_active IP Right Cessation
- 2006-06-26 WO PCT/EP2006/063533 patent/WO2007003521A2/en active Application Filing
- 2006-06-26 AU AU2006265201A patent/AU2006265201C1/en not_active Ceased
- 2006-06-26 RU RU2008103483/04A patent/RU2401832C2/ru not_active IP Right Cessation
- 2006-06-26 CN CN200680023527XA patent/CN101528713B/zh not_active Expired - Fee Related
- 2006-06-26 MX MX2007016352A patent/MX2007016352A/es active IP Right Grant
- 2006-06-26 CA CA2612740A patent/CA2612740C/en not_active Expired - Fee Related
- 2006-06-26 NZ NZ564260A patent/NZ564260A/en not_active IP Right Cessation
- 2006-06-26 PT PT06777461T patent/PT1904455E/pt unknown
- 2006-06-26 SI SI200631140T patent/SI1904455T1/sl unknown
- 2006-06-26 DK DK06777461.2T patent/DK1904455T3/da active
- 2006-06-26 RS RS20110396A patent/RS51994B/en unknown
- 2006-06-26 BR BRPI0613565-0A patent/BRPI0613565A2/pt not_active IP Right Cessation
- 2006-06-26 EP EP06777461A patent/EP1904455B1/en active Active
- 2006-06-26 PL PL06777461T patent/PL1904455T3/pl unknown
- 2006-07-03 TW TW095124178A patent/TWI323258B/zh active
- 2006-07-03 AR ARP060102856A patent/AR054814A1/es not_active Application Discontinuation
- 2006-07-03 MY MYPI20063158A patent/MY144209A/en unknown
- 2006-07-05 US US11/481,330 patent/US7678795B2/en not_active Expired - Fee Related
-
2007
- 2007-12-11 CR CR9587A patent/CR9587A/es unknown
- 2007-12-14 NO NO20076431A patent/NO20076431L/no not_active Application Discontinuation
- 2007-12-17 IL IL188182A patent/IL188182A/en not_active IP Right Cessation
- 2007-12-18 ZA ZA200710972A patent/ZA200710972B/xx unknown
-
2008
- 2008-01-04 EC EC2008008082A patent/ECSP088082A/es unknown
- 2008-01-04 MA MA30542A patent/MA29909B1/fr unknown
-
2009
- 2009-10-06 CL CL2009001936A patent/CL2009001936A1/es unknown
-
2010
- 2010-02-25 HK HK10101976.4A patent/HK1134087A1/xx not_active IP Right Cessation
-
2011
- 2011-09-28 CY CY20111100942T patent/CY1112401T1/el unknown
- 2011-11-02 HR HR20110808T patent/HRP20110808T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |